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学科主题: 临床医学
题名:
Anti-inflammatory effects of eplerenone on viral myocarditis
作者: Xiao, Jie1,3; Shimada, Miho1; Liu, Wenling1,2; Hu, Dayi2; Matsumori, Akira1
关键词: Viruses ; Myocarditis ; Inflammation ; Mast cells ; Eplerenone ; Fibrosis ; Heart failure
刊名: EUROPEAN JOURNAL OF HEART FAILURE
发表日期: 2009-04-01
DOI: 10.1093/eurjhf/hfp023
卷: 11, 期:4, 页:349-353
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: MAST-CELL CHYMASE ; ANGIOTENSIN-II ; NADPH OXIDASE ; DILATED CARDIOMYOPATHY ; UP-REGULATION ; ALDOSTERONE ; ATHEROSCLEROSIS ; INFLAMMATION ; ACTIVATION ; TRYPTASE
英文摘要:

Inflammation contributes to increased cardiovascular morbidity and mortality associated with activation of the renin-angiotensin-aldosterone system. The aim of this study was to investigate whether eplerenone, a selective aldosterone receptor antagonist, has anti-inflammatory effects on viral myocarditis.

Four-week-old inbred male DBA/2 mice were inoculated intraperitoneally with 10 plaque-forming units (pfu) of the encephalomyocarditis (EMC) virus. Mice were fed with standard chow (control) or with chow containing 2.5 mg/kg of eplerenone, starting either on day 0 (inoculation) or day 7. Survival at 28 days was significantly higher in the mice which started eplerenone treatment on day 0 (35 vs. 15% in controls, each n = 40, P < 0.05). The area of myocardial fibrosis on day 28 was significantly smaller in the eplerenone-treated mice than in controls (19.8 +/- 2.6%, n = 14, vs. 33.4 +/- 5.4%, n = 6, mean +/- SEM, P < 0.05). Gene expression of mouse mast cell proteases-4 and -5, matrix metalloproteinase-9, and type I procollagen on day 6 after EMC virus inoculation was significantly decreased in the hearts of eplerenone-treated mice.

These results suggest that eplerenone has anti-inflammatory effects, and exerts its beneficial effects on viral myocarditis by suppression of genes related to mast cells and cardiac remodelling in the hearts of mice.

语种: 英语
项目资助者: Japanese Ministry of Health, Labour, and Welfare ; Japanese Ministry of Education, Culture, Sports, Science, and Technology
WOS记录号: WOS:000266346300004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51217
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Beijing, Peoples R China
2.Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, Kyoto 6068507, Japan
3.Capital Med Univ, Beijing Tongren Hosp, Beijing 100730, Peoples R China

Recommended Citation:
Xiao, Jie,Shimada, Miho,Liu, Wenling,et al. Anti-inflammatory effects of eplerenone on viral myocarditis[J]. EUROPEAN JOURNAL OF HEART FAILURE,2009,11(4):349-353.
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