北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 肿瘤外科  > 期刊论文
学科主题: 临床医学
题名:
Therapeutic Implications of mTOR Inhibitors in the Treatment of Gastric Cancer
作者: Bu, Zhaode1,2; Ji, Jiafu1,2
关键词: Everolimus ; gastric cancer ; mTOR inhibitors
刊名: CURRENT CANCER DRUG TARGETS
发表日期: 2013-02-01
卷: 13, 期:2, 页:121-125
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: MAMMALIAN TARGET ; PHASE-III ; EXPRESSION ; EVEROLIMUS ; CISPLATIN ; PATHWAY ; CELLS ; 5-FLUOROURACIL ; FLUOROURACIL ; OUTCOMES
英文摘要:

Gastric cancer remains one of the most common types of cancer worldwide, and most patients present with advanced disease. Sixty percent of these patients eventually relapse after curative surgical resection, and combination chemotherapy regimens only provide limited survival benefits. Mammalian target of rapamycin (mTOR) is a new target of cancer therapies. Preclinical data suggest that the suppression of the mTOR pathway inhibits the progression of gastric cancer in vitro and in animal models. In clinical trials, the mTOR inhibitor, everolimus, was well tolerated in phase I/II studies on patients with metastatic gastric cancer. The efficacy of everolimus was promising in a phase II clinical trial, but in a recently published phase III clinical trial everolimus monotherapy do not significantly improve the overall survival of patients with advanced gastric cancer who had been previously treated with one or two lines of systemic chemotherapy. Phosphoinositide 3-kinase/mTOR dual inhibitors have not yet entered early-stage clinical trials in patients with advanced gastric cancer. Further studies are needed to establish the role of mTOR inhibitors for the treatment of gastric cancer.

语种: 英语
所属项目编号: 2011BAZ03191 ; 2011ZX09307-001-05
项目资助者: National Key Technology RD Program ; National "Twelfth Five-Year" special science and technology major projects
WOS记录号: WOS:000317923100002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51218
Appears in Collections:北京大学临床肿瘤学院_肿瘤外科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ Canc Hosp & Inst, Dept Surg, Beijing 100142, Peoples R China

Recommended Citation:
Bu, Zhaode,Ji, Jiafu. Therapeutic Implications of mTOR Inhibitors in the Treatment of Gastric Cancer[J]. CURRENT CANCER DRUG TARGETS,2013,13(2):121-125.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Bu, Zhaode]'s Articles
[Ji, Jiafu]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Bu, Zhaode]‘s Articles
[Ji, Jiafu]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace