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学科主题临床医学
Therapeutic Implications of mTOR Inhibitors in the Treatment of Gastric Cancer
Bu, Zhaode1,2; Ji, Jiafu1,2
关键词Everolimus Gastric Cancer Mtor Inhibitors
刊名CURRENT CANCER DRUG TARGETS
2013-02-01
13期:2页:121-125
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]MAMMALIAN TARGET ; PHASE-III ; EXPRESSION ; EVEROLIMUS ; CISPLATIN ; PATHWAY ; CELLS ; 5-FLUOROURACIL ; FLUOROURACIL ; OUTCOMES
英文摘要

Gastric cancer remains one of the most common types of cancer worldwide, and most patients present with advanced disease. Sixty percent of these patients eventually relapse after curative surgical resection, and combination chemotherapy regimens only provide limited survival benefits. Mammalian target of rapamycin (mTOR) is a new target of cancer therapies. Preclinical data suggest that the suppression of the mTOR pathway inhibits the progression of gastric cancer in vitro and in animal models. In clinical trials, the mTOR inhibitor, everolimus, was well tolerated in phase I/II studies on patients with metastatic gastric cancer. The efficacy of everolimus was promising in a phase II clinical trial, but in a recently published phase III clinical trial everolimus monotherapy do not significantly improve the overall survival of patients with advanced gastric cancer who had been previously treated with one or two lines of systemic chemotherapy. Phosphoinositide 3-kinase/mTOR dual inhibitors have not yet entered early-stage clinical trials in patients with advanced gastric cancer. Further studies are needed to establish the role of mTOR inhibitors for the treatment of gastric cancer.

语种英语
WOS记录号WOS:000317923100002
项目编号2011BAZ03191 ; 2011ZX09307-001-05
资助机构National Key Technology RD Program ; National "Twelfth Five-Year" special science and technology major projects
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51218
专题北京大学临床肿瘤学院_肿瘤外科
北京大学临床肿瘤学院_胃肠肿瘤中心一病区
作者单位1.Peking Univ Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ Canc Hosp & Inst, Dept Surg, Beijing 100142, Peoples R China
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GB/T 7714
Bu, Zhaode,Ji, Jiafu. Therapeutic Implications of mTOR Inhibitors in the Treatment of Gastric Cancer[J]. CURRENT CANCER DRUG TARGETS,2013,13(2):121-125.
APA Bu, Zhaode,&Ji, Jiafu.(2013).Therapeutic Implications of mTOR Inhibitors in the Treatment of Gastric Cancer.CURRENT CANCER DRUG TARGETS,13(2),121-125.
MLA Bu, Zhaode,et al."Therapeutic Implications of mTOR Inhibitors in the Treatment of Gastric Cancer".CURRENT CANCER DRUG TARGETS 13.2(2013):121-125.
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