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学科主题: 临床医学
题名:
Endoplasmic reticulum stress response is involved in the pathogenesis of stress induced gastric lesions in rats
作者: Lou, Li Xia1; Geng, Bin1; Yu, Fang1; Zhang, Jing1; Pan, Chun Shui1; Chen, Li1; Qi, Yong Fen1; Ke, Ya1; Wang, Xian1; Tang, Chao Shu1
关键词: endoplasmic reticulum stress ; stress gastric ulcer ; water-immersion and restraint stress ; apoptosis
刊名: LIFE SCIENCES
发表日期: 2006-10-04
DOI: 10.1016/j.lfs.2006.06.022
卷: 79, 期:19, 页:1856-1864
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: UNFOLDED PROTEIN RESPONSE ; EPIDERMAL GROWTH-FACTOR ; NECROSIS-FACTOR-ALPHA ; MUCOSAL BLOOD-FLOW ; CELL-DEATH PROGRAM ; UP-REGULATION ; APOPTOSIS ; ACTIVATION ; PROSTAGLANDIN ; INDOMETHACIN
英文摘要:

Stress gastric ulcer is a serious complication, but the mechanism involved is not fully clarified. It is well known that mucosal cell apoptosis plays a crucial role in the pathogenesis of gastric ulceration. Recent studies have shown that endoplasmic reticulum (ER) stress is an important pathway leading to cellular apoptosis. To investigate the role of ER stress in the pathogenesis of stress gastric ulcer, we studied the alteration in the expression of ER stress markers GRP78 (glucose-regulated protein 78) and caspase-12 (an ER stress-specific proapoptotic molecule) and their relations with gastric mucosal apoptosis during development of stress gastric lesions in the water-immersion and restraint stress (WRS) model in rats. Rats developed severe gastric lesions after 6 h of WRS. Typical apoptosis was observed at the edge cells of WRS induced gastric lesions. Western blot analysis showed that GRP78 and activated caspase-12 were over-expressed in the gastric tissues of WRS rats. Immunchistochemical analysis demonstrated that increased GRP78 and caspase-12 were distributed only under the lesions. In addition, dithiothreitol and tunicamycin (ER stress inducers), which increased the expression of GRP78 and activated caspase-12, caused gastric mucosal injury and mucosal cell apoptosis in vitro. These findings suggest that ER stress might be involved in the development of stress gastric ulcer through an apoptotic mechanism. (c) 2006 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000241223700011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51222
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Ctr Hlth Sci, Dept Physiol & Pathophysiol, Beijing 100083, Peoples R China
2.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100083, Peoples R China
3.Peking Univ, Hosp 1, Inst Cardiovasc Dis, Beijing 100034, Peoples R China

Recommended Citation:
Lou, Li Xia,Geng, Bin,Yu, Fang,et al. Endoplasmic reticulum stress response is involved in the pathogenesis of stress induced gastric lesions in rats[J]. LIFE SCIENCES,2006,79(19):1856-1864.
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