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Combination of Targeted PDT and Anti-VEGF Therapy for Rat CNV by RGD-Modified Liposomal Photocyanine and Sorafenib
Wang, Jia-lin1; Xi, Yi1; Liu, Yu-ling1; Wang, Zhao-hui2; Zhang, Qiang2
关键词Choroidal Neovascularization Targeted Pdt Anti-vegf Photocyanine Sorafenib Rgd Peptide Liposomes
刊名INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
2013-12-01
DOI10.1167/iovs.13-13068
54期:13页:7983-7989
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
资助者National Science Foundation ; Ministry of Science and Technology of China ; Ministry of Education ; National Science Foundation ; Ministry of Science and Technology of China ; Ministry of Education
研究领域[WOS]Ophthalmology
关键词[WOS]EXPERIMENTAL CHOROIDAL NEOVASCULARIZATION ; PHOTODYNAMIC THERAPY ; MACULAR DEGENERATION ; COMBRETASTATIN A-4 ; CELLS ; DELIVERY ; RANIBIZUMAB ; DOXORUBICIN ; APOPTOSIS ; ZNPCS2P2
英文摘要

PURPOSE. To achieve a combination therapy of targeted PDT and anti-VEGF for choroidal neovascularization (CNV).

METHODS. Arg-Gly-Asp (RGD)-modified liposomes encapsulating photocyanine and sorafenib (RGD-SSL-[P]-[S]) were prepared and characterized. Drug concentration in RGD-SSL-[P]-[S] and irradiation time were optimized on ARPE-19 and HUVEC cells in vitro. A laser-induced CNV rat model was used to assess the efficacy of this targeted combinational system. The effect of RGD-SSL-[P]-[S] on the retinal structure of BN rats was also examined.

RESULTS. The particle size of RGD-SSL-[P]-[S] was approximately 100 nm, with a encapsulation efficiency more than 90% for both photocyanine and sorafenib. From RGD-SSL-[P]-[S], the release rate of photocyanine was approximately 22%, whereas that of sorafeinb was approximately 40% at 48 hours. With the optimal drug concentration and irradiation time, RGD-SSL-[P]-[S] exhibited cytotoxicity only to HUVEC without obvious damage to normal ARPE-19 cells. Rats treated with RGD-SSL-[P]-[S] showed the least CNV area and fluorescein leakage in fluorescein fundus angiography. RGD-SSL-[P]-[S] was also found safe to the rat retina.

CONCLUSIONS. Combination of targeted PDT and anti-VEGF might be an effective therapy for CNV.

语种英语
所属项目编号81130059 ; 2009CB930300 ; 2009ZX09310-001 ; BMU20110263
资助者National Science Foundation ; Ministry of Science and Technology of China ; Ministry of Education ; National Science Foundation ; Ministry of Science and Technology of China ; Ministry of Education
WOS记录号WOS:000328133800019
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51223
专题北京大学第三临床医学院_眼科
作者单位1.Peking Univ, Hosp 3, Ctr Eye, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimot Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wang, Jia-lin,Xi, Yi,Liu, Yu-ling,et al. Combination of Targeted PDT and Anti-VEGF Therapy for Rat CNV by RGD-Modified Liposomal Photocyanine and Sorafenib[J]. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,2013,54(13):7983-7989.
APA Wang, Jia-lin,Xi, Yi,Liu, Yu-ling,Wang, Zhao-hui,&Zhang, Qiang.(2013).Combination of Targeted PDT and Anti-VEGF Therapy for Rat CNV by RGD-Modified Liposomal Photocyanine and Sorafenib.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,54(13),7983-7989.
MLA Wang, Jia-lin,et al."Combination of Targeted PDT and Anti-VEGF Therapy for Rat CNV by RGD-Modified Liposomal Photocyanine and Sorafenib".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 54.13(2013):7983-7989.
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