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Synthesis and recognition of novel isonucleoside triphosphates by DNA polymerases
Jiang, Caiwu1; Li, Bingchao1; Guan, Zhu1; Yang, Zhenjun1; Zhang, Liangren1; Zhang, Lihe1
关键词Dna Polymerase Isonucleoside Triphosphate Recognition
刊名BIOORGANIC & MEDICINAL CHEMISTRY
2007-04-15
DOI10.1016/j.bmc.2007.02.003
15期:8页:3019-3025
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
关键词[WOS]OLIGONUCLEOTIDES ; MONOPHOSPHATE ; INHIBITION ; METABOLISM ; KINASE
英文摘要

Isonucleosides have been attracting a lot of attention in recent years due to the chemical and enzymatic stability and potential anticancer and antiviral activities. We have reported some of the isonucleosides which exhibited significant anticancer activity and found that the oligonucleotide incorporated with isonucleoside could increase the enzymatic stability against the degradation by phosphodiesterase. In this paper, we investigated the recognition of the isonucleoside triphosphates 1-6 by Taq, Vent(exo(-)), DeepVent(exo(-)), 9 degrees Nm, and Therminator DNA polymerases by a non-radioactivity method. We found that most of the isonucleoside triphosphates can be recognized by various DNA polymerase and act as terminators. Isonucleoside triphosphates 2 and 6 can be incorporated as substrates into the primer at 3′ terminus to lengthen the chain dependent on a DNA template by Vent(exo(-)) and DeepVent(exo(-)) DNA polymerases. (c) 2007 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000245637200023
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51225
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drug, Beijing 100083, Peoples R China
2.Guangxi Tradit Chinese Med Univ, Sch Pharm, Nanning 530001, Guangxi, Peoples R China
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GB/T 7714
Jiang, Caiwu,Li, Bingchao,Guan, Zhu,et al. Synthesis and recognition of novel isonucleoside triphosphates by DNA polymerases[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2007,15(8):3019-3025.
APA Jiang, Caiwu,Li, Bingchao,Guan, Zhu,Yang, Zhenjun,Zhang, Liangren,&Zhang, Lihe.(2007).Synthesis and recognition of novel isonucleoside triphosphates by DNA polymerases.BIOORGANIC & MEDICINAL CHEMISTRY,15(8),3019-3025.
MLA Jiang, Caiwu,et al."Synthesis and recognition of novel isonucleoside triphosphates by DNA polymerases".BIOORGANIC & MEDICINAL CHEMISTRY 15.8(2007):3019-3025.
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