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学科主题: 药学
题名:
A novel and efficient direct aldol condensation from ketones and aromatic aldehydes catalyzed by proline-TEA through a new pathway
作者: Wang, Jun-feng; Lei, Meng; Li, Qin; Ge, Ze-mei; Wang, Xin; Li, Run-tao
关键词: Proline ; Aldol Condensation ; C-glycosides ; New pathway ; Intermediate
刊名: TETRAHEDRON
发表日期: 2009-06-20
DOI: 10.1016/j.tet.2009.04.052
卷: 65, 期:25, 页:4826-4833
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: CLAISEN-SCHMIDT CONDENSATION ; ALPHA,BETA-UNSATURATED KETONES ; C-GLYCOSIDES ; DERIVATIVES ; STEREOSELECTIVITY ; ACETYLATION ; CONVENIENT ; ADDITIONS ; WATER ; ACID
英文摘要:

A novel and efficient direct aldol condensation from various ketones and a wide range of aldehydes was catalyzed by L-proline-TEA (triethylamine) in MeOH at room temperature, affording the corresponding (E)-alpha,beta-unsaturated ketones in excellent yields. By using the method, some complicated (E)-alpha,beta-unsaturated ketone C-glycosides were obtained from unmodified ketone C-glycosides and aldehydes. This reaction proceeds through a new pathway, in which the specific intermediate was captured and identified. (C) 2009 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 20572004 ; 2004CB-719900
项目资助者: National Natural Science Foundation of China ; Major State Basic Research Development Program
WOS记录号: WOS:000267009400007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51229
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Jun-feng,Lei, Meng,Li, Qin,et al. A novel and efficient direct aldol condensation from ketones and aromatic aldehydes catalyzed by proline-TEA through a new pathway[J]. TETRAHEDRON,2009,65(25):4826-4833.
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