IR@PKUHSC  > 中国药物依赖性研究所
学科主题药物依赖
Hippocampal CLOCK protein participates in the persistence of depressive-like behavior induced by chronic unpredictable stress
Jiang, Wen-Gao; Li, Su-Xia; Liu, Jian-Feng; Sun, Yan; Zhou, Shuang-Jiang; Zhu, Wei-Li; Shi, Jie; Lu, Lin
关键词Depression Chronic Unpredictable Stress Clock Bmal1 Suprachiasmatic Nucleus Hippocampus
刊名PSYCHOPHARMACOLOGY
2013-05-01
DOI10.1007/s00213-012-2941-4
227期:1页:79-92
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]CHRONIC MILD STRESS ; RECEPTOR GENE-EXPRESSION ; BDNF MESSENGER-RNA ; SUPRACHIASMATIC NUCLEUS ; CIRCADIAN-RHYTHMS ; MAJOR DEPRESSION ; NMDA RECEPTORS ; BRAIN-REGIONS ; LOCOMOTOR-ACTIVITY ; BIPOLAR DISORDER
英文摘要

Circadian disturbances are strongly linked with major depression. The circadian proteins CLOCK and BMAL1 are abundantly expressed but function differently in the suprachiasmatic nucleus (SCN) and hippocampus. However, their roles in depressive-like behavior are still poorly understood.

To investigate the alterations of CLOCK and BMAL1 in the SCN and hippocampus in rats subjected to chronic unpredictable stress (CUS) and to explore the relationship of circadian protein and the depressive-like behavior.

Together with depressive-like behavior induced by CUS, CLOCK and BMAL1 in the SC were inhibited during the light period, and the peak expression of CLOCK in the hippocampus was shifted from the dark to light period. BMAL1 expression in the hippocampus was not significantly changed. Two weeks after the termination of CUS, abnormalities of CLOCK in the CA1 and CA3 endured, with unchanged depressive-like behavior, but the expression of CLOCK and BMAL1 in the SCN recovered to control levels. Knockdown of the Clock gene in CA1 induced depressive-like behavior in normal rats. CLOCK in the SCN and hippocampus may participate in the development of depressive-like behavior. However, CLOCK in the hippocampus but not SCN was involved in the long-lasting effects of CUS on depressive-like behavior. BMAL1 in the hippocampus appeared to be unrelated to the effects of CUS on depressive-like behavior.

CLOCK protein in the hippocampus but not SCN play an important role in the long-lasting depressive-like behavior induced by CUS. These findings suggest a novel therapeutic target in the development of new antidepressants focusing on the regulation of circadian rhythm.

语种英语
所属项目编号30800362
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000317858000007
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51230
专题中国药物依赖性研究所
作者单位Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Jiang, Wen-Gao,Li, Su-Xia,Liu, Jian-Feng,et al. Hippocampal CLOCK protein participates in the persistence of depressive-like behavior induced by chronic unpredictable stress[J]. PSYCHOPHARMACOLOGY,2013,227(1):79-92.
APA Jiang, Wen-Gao.,Li, Su-Xia.,Liu, Jian-Feng.,Sun, Yan.,Zhou, Shuang-Jiang.,...&Lu, Lin.(2013).Hippocampal CLOCK protein participates in the persistence of depressive-like behavior induced by chronic unpredictable stress.PSYCHOPHARMACOLOGY,227(1),79-92.
MLA Jiang, Wen-Gao,et al."Hippocampal CLOCK protein participates in the persistence of depressive-like behavior induced by chronic unpredictable stress".PSYCHOPHARMACOLOGY 227.1(2013):79-92.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Jiang, Wen-Gao]的文章
[Li, Su-Xia]的文章
[Liu, Jian-Feng]的文章
百度学术
百度学术中相似的文章
[Jiang, Wen-Gao]的文章
[Li, Su-Xia]的文章
[Liu, Jian-Feng]的文章
必应学术
必应学术中相似的文章
[Jiang, Wen-Gao]的文章
[Li, Su-Xia]的文章
[Liu, Jian-Feng]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。