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学科主题: 药物依赖
题名:
Hippocampal CLOCK protein participates in the persistence of depressive-like behavior induced by chronic unpredictable stress
作者: Jiang, Wen-Gao; Li, Su-Xia; Liu, Jian-Feng; Sun, Yan; Zhou, Shuang-Jiang; Zhu, Wei-Li; Shi, Jie; Lu, Lin
关键词: Depression ; Chronic unpredictable stress ; CLOCK ; BMAL1 ; Suprachiasmatic nucleus ; Hippocampus
刊名: PSYCHOPHARMACOLOGY
发表日期: 2013-05-01
DOI: 10.1007/s00213-012-2941-4
卷: 227, 期:1, 页:79-92
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: CHRONIC MILD STRESS ; RECEPTOR GENE-EXPRESSION ; BDNF MESSENGER-RNA ; SUPRACHIASMATIC NUCLEUS ; CIRCADIAN-RHYTHMS ; MAJOR DEPRESSION ; NMDA RECEPTORS ; BRAIN-REGIONS ; LOCOMOTOR-ACTIVITY ; BIPOLAR DISORDER
英文摘要:

Circadian disturbances are strongly linked with major depression. The circadian proteins CLOCK and BMAL1 are abundantly expressed but function differently in the suprachiasmatic nucleus (SCN) and hippocampus. However, their roles in depressive-like behavior are still poorly understood.

To investigate the alterations of CLOCK and BMAL1 in the SCN and hippocampus in rats subjected to chronic unpredictable stress (CUS) and to explore the relationship of circadian protein and the depressive-like behavior.

Together with depressive-like behavior induced by CUS, CLOCK and BMAL1 in the SC were inhibited during the light period, and the peak expression of CLOCK in the hippocampus was shifted from the dark to light period. BMAL1 expression in the hippocampus was not significantly changed. Two weeks after the termination of CUS, abnormalities of CLOCK in the CA1 and CA3 endured, with unchanged depressive-like behavior, but the expression of CLOCK and BMAL1 in the SCN recovered to control levels. Knockdown of the Clock gene in CA1 induced depressive-like behavior in normal rats. CLOCK in the SCN and hippocampus may participate in the development of depressive-like behavior. However, CLOCK in the hippocampus but not SCN was involved in the long-lasting effects of CUS on depressive-like behavior. BMAL1 in the hippocampus appeared to be unrelated to the effects of CUS on depressive-like behavior.

CLOCK protein in the hippocampus but not SCN play an important role in the long-lasting depressive-like behavior induced by CUS. These findings suggest a novel therapeutic target in the development of new antidepressants focusing on the regulation of circadian rhythm.

语种: 英语
所属项目编号: 30800362
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000317858000007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51230
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China

Recommended Citation:
Jiang, Wen-Gao,Li, Su-Xia,Liu, Jian-Feng,et al. Hippocampal CLOCK protein participates in the persistence of depressive-like behavior induced by chronic unpredictable stress[J]. PSYCHOPHARMACOLOGY,2013,227(1):79-92.
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