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Stress Enhances Retrieval of Drug-Related Memories in Abstinent Heroin Addicts
Zhao, Li-Yan1; Shi, Jie1; Zhang, Xiao-Li1; Epstein, David H.2; Zhang, Xiang-Yang3; Liu, Yu1; Kosten, Thomas R.3; Lu, Lin1
关键词Stress Cortisol Heroin-related Memory Retrieval Norepinephrine
刊名NEUROPSYCHOPHARMACOLOGY
2010-02-01
DOI10.1038/npp.2009.179
35期:3页:720-726
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]BASOLATERAL AMYGDALA ; SPATIAL MEMORY ; LONG-TERM ; NORADRENERGIC ACTIVATION ; RETENTION PERFORMANCE ; PSYCHOSOCIAL STRESS ; EMOTIONAL AROUSAL ; SEX-DIFFERENCES ; HPA AXIS ; GLUCOCORTICOIDS
英文摘要

Stress is associated with relapse to drugs after abstinence, but the mechanisms for this association are unclear. One mechanism may be that stress enhances abstinent addicts′ recall of memories of drugs as stress relievers. This study assessed the effects of stress on free recall and cued recall of 10 heroin-related and 10 neutral words learned 24 h earlier by 102 abstinent heroin addicts. These participants were randomly assigned to three experiments that also assessed attention and working memory. Experiment 1 used a psychosocial stressor (Trier social stress test (TSST)) before testing for recall of heroin-related words. Experiment 2 added administration of the beta-adrenoceptor antagonist propranolol 1 h before the psychosocial stressor. Experiment 3 added administration of either cortisol with propranolol, cortisol alone, or propranolol alone 1 h before word recall to determine whether stress enhancement of heroin-related word recall required noradrenergic-glucocorticoid interactions. We found that free recall of heroin-related words in abstinent addicts was enhanced after stress or cortisol administration when compared with a non-stress condition or placebo, respectively, whereas these interventions had no effect on neutral word recall. beta-adrenergic blockade blocked the enhancing effect of stress or cortisol on free recall of heroin-related words. Neither stress nor cortisol affected cued recall, attention, or working memory. The potential of b-adrenergic blockade to reduce or block stress-induced enhancement of drug-related memory retrieval may be relevant to preventing stress-induced relapse in abstinent heroin addicts. Neuropsychopharmacology (2010) 35, 720-726; doi:10.1038/npp.2009.179; published online 4 November 2009

语种英语
WOS记录号WOS:000273635100013
项目编号973 ; 2007CB512302 ; 2009CB522000 ; 30670713 ; 30725016
资助机构National Basic Research Program of China ; Natural Science Foundation of China
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51231
专题中国药物依赖性研究所
北京大学医学部管理机构_医学部
作者单位1.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
2.Natl Inst Drug Abuse, Intramural Res Program, NIH, Baltimore, MD USA
3.Baylor Coll Med, Div Alcohol & Addict Disorders, Houston, TX 77030 USA
推荐引用方式
GB/T 7714
Zhao, Li-Yan,Shi, Jie,Zhang, Xiao-Li,et al. Stress Enhances Retrieval of Drug-Related Memories in Abstinent Heroin Addicts[J]. NEUROPSYCHOPHARMACOLOGY,2010,35(3):720-726.
APA Zhao, Li-Yan.,Shi, Jie.,Zhang, Xiao-Li.,Epstein, David H..,Zhang, Xiang-Yang.,...&Lu, Lin.(2010).Stress Enhances Retrieval of Drug-Related Memories in Abstinent Heroin Addicts.NEUROPSYCHOPHARMACOLOGY,35(3),720-726.
MLA Zhao, Li-Yan,et al."Stress Enhances Retrieval of Drug-Related Memories in Abstinent Heroin Addicts".NEUROPSYCHOPHARMACOLOGY 35.3(2010):720-726.
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