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学科主题: 临床医学
题名:
Alteration of ER beta gene RsaI polymorphism may contribute to reduced fertilization rate and embryonic developmental competence
作者: Zhang, Qiu-Fang1; Feng, Huai-Liang2; Zhao, Lan1; Liu, Ping1; Li, Li1; Yan, Jie1; Qiao, Jie1
关键词: embryo development ; estrogen receptor-beta gene ; fertilization ; intracytoplasmic sperm injection ; in vitro fertilization ; polymorphism
刊名: ASIAN JOURNAL OF ANDROLOGY
发表日期: 2011-03-01
DOI: 10.1038/aja.2010.150
卷: 13, 期:2, 页:317-321
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Andrology ; Urology & Nephrology
研究领域[WOS]: Endocrinology & Metabolism ; Urology & Nephrology
关键词[WOS]: ESTROGEN-RECEPTOR-ALPHA ; MALE REPRODUCTIVE-SYSTEM ; MALE-INFERTILITY ; AROMATASE DEFICIENCY ; OVARIAN STIMULATION ; GENOME ACTIVATION ; SEMEN QUALITY ; HUMAN TESTIS ; EXPRESSION ; LOCALIZATION
英文摘要:

This paper aims to determine the possible role of estrogen receptor-beta (ER beta) gene RsaI polymorphism on sperm fertility and early embryonic development in humans. Three groups of Chinese men were recruited: in vitro fertilization (IVF) group, including 374 couples who underwent conventional IVF; intracytoplasmic sperm injection (ICSI) group, including 294 couples who underwent an ICSI procedure using ejaculated sperm; and azoospermic group, consisting of 197 couples who underwent ICSI using either testis or epididymis sperm. RsaI polymorphism in the ER beta gene was detected by polymerase chain reaction (PCR)-restriction fragment length polymorphism technique; fertilization and high-quality embryo rates were evaluated for each group. In each group, no significant differences were found in the overall rates of fertilization and high-quality embryos among GG, AG and AA genotypes. However, the proportion of cycles possessing a satisfactory high-quality embryo rate with the AA genotype was significantly lower than that in the wild-type GG genotype from each group. These results demonstrated that sperm possessing the ER beta RsaI A genotype may have reduced fertilization ability and decreased early embryonic developmental potential, which could directly or indirectly contribute to the low fertilization rate and early embryonic developmental arrest in some cases. Asian Journal of Andrology (2011) 13, 317-321; doi:10.1038/aja.2010.150; published online 6 December 2010

语种: 英语
所属项目编号: 2007ZB948102
项目资助者: national basic research program of China (973 Program)
WOS记录号: WOS:000288074400034
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51233
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Ctr Reprod Med, Beijing 1000191, Peoples R China
2.NYU, Sch Med, N Shore Univ Hosp, Ctr Human Reprod, Manhasset, NY 11030 USA

Recommended Citation:
Zhang, Qiu-Fang,Feng, Huai-Liang,Zhao, Lan,et al. Alteration of ER beta gene RsaI polymorphism may contribute to reduced fertilization rate and embryonic developmental competence[J]. ASIAN JOURNAL OF ANDROLOGY,2011,13(2):317-321.
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