IR@PKUHSC  > 北京大学第三临床医学院  > 生殖医学中心
学科主题临床医学
Alteration of ER beta gene RsaI polymorphism may contribute to reduced fertilization rate and embryonic developmental competence
Zhang, Qiu-Fang1; Feng, Huai-Liang2; Zhao, Lan1; Liu, Ping1; Li, Li1; Yan, Jie1; Qiao, Jie1
关键词Embryo Development Estrogen Receptor-beta Gene Fertilization Intracytoplasmic Sperm Injection In Vitro Fertilization Polymorphism
刊名ASIAN JOURNAL OF ANDROLOGY
2011-03-01
DOI10.1038/aja.2010.150
13期:2页:317-321
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Andrology ; Urology & Nephrology
资助者national basic research program of China (973 Program) ; national basic research program of China (973 Program)
研究领域[WOS]Endocrinology & Metabolism ; Urology & Nephrology
关键词[WOS]ESTROGEN-RECEPTOR-ALPHA ; MALE REPRODUCTIVE-SYSTEM ; MALE-INFERTILITY ; AROMATASE DEFICIENCY ; OVARIAN STIMULATION ; GENOME ACTIVATION ; SEMEN QUALITY ; HUMAN TESTIS ; EXPRESSION ; LOCALIZATION
英文摘要

This paper aims to determine the possible role of estrogen receptor-beta (ER beta) gene RsaI polymorphism on sperm fertility and early embryonic development in humans. Three groups of Chinese men were recruited: in vitro fertilization (IVF) group, including 374 couples who underwent conventional IVF; intracytoplasmic sperm injection (ICSI) group, including 294 couples who underwent an ICSI procedure using ejaculated sperm; and azoospermic group, consisting of 197 couples who underwent ICSI using either testis or epididymis sperm. RsaI polymorphism in the ER beta gene was detected by polymerase chain reaction (PCR)-restriction fragment length polymorphism technique; fertilization and high-quality embryo rates were evaluated for each group. In each group, no significant differences were found in the overall rates of fertilization and high-quality embryos among GG, AG and AA genotypes. However, the proportion of cycles possessing a satisfactory high-quality embryo rate with the AA genotype was significantly lower than that in the wild-type GG genotype from each group. These results demonstrated that sperm possessing the ER beta RsaI A genotype may have reduced fertilization ability and decreased early embryonic developmental potential, which could directly or indirectly contribute to the low fertilization rate and early embryonic developmental arrest in some cases. Asian Journal of Andrology (2011) 13, 317-321; doi:10.1038/aja.2010.150; published online 6 December 2010

语种英语
所属项目编号2007ZB948102
资助者national basic research program of China (973 Program) ; national basic research program of China (973 Program)
WOS记录号WOS:000288074400034
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51233
Collection北京大学第三临床医学院_生殖医学中心
作者单位1.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Ctr Reprod Med, Beijing 1000191, Peoples R China
2.NYU, Sch Med, N Shore Univ Hosp, Ctr Human Reprod, Manhasset, NY 11030 USA
Recommended Citation
GB/T 7714
Zhang, Qiu-Fang,Feng, Huai-Liang,Zhao, Lan,et al. Alteration of ER beta gene RsaI polymorphism may contribute to reduced fertilization rate and embryonic developmental competence[J]. ASIAN JOURNAL OF ANDROLOGY,2011,13(2):317-321.
APA Zhang, Qiu-Fang.,Feng, Huai-Liang.,Zhao, Lan.,Liu, Ping.,Li, Li.,...&Qiao, Jie.(2011).Alteration of ER beta gene RsaI polymorphism may contribute to reduced fertilization rate and embryonic developmental competence.ASIAN JOURNAL OF ANDROLOGY,13(2),317-321.
MLA Zhang, Qiu-Fang,et al."Alteration of ER beta gene RsaI polymorphism may contribute to reduced fertilization rate and embryonic developmental competence".ASIAN JOURNAL OF ANDROLOGY 13.2(2011):317-321.
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