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Expression of the Parkinson′s Disease-Related Protein DJ-1 during Neural Stem Cell Proliferation
Yan, Hui1,2; Pu, Xiao-Ping1,2
关键词Neural Stem Cell Dj-1 Nestin Proliferation Parkinson&Prime s Disease
刊名BIOLOGICAL & PHARMACEUTICAL BULLETIN
2010
33期:1页:18-21
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
资助者National Program for Key Basic Research ; National Program for Key Basic Research
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]PATHOGENESIS ; MUTATIONS ; PROSPECTS ; NEURONS ; STRESS ; ALPHA ; MODEL
英文摘要

Neural stem cells (NSCs) arise through neurogenesis, and comprise all newly-formed neurons in the central and peripheral nervous systems. DJ-1 is associated with autosomal recessive familial Parkinson′s disease (PD). The relationship between DJ-1 and NSC proliferation may shed light on the underlying pathogenesis of, and potential treatments for, PD. To investigate the relationship between DJ-1 and NSCs, embryonic cortical NSCs were isolated and cultured from E14 fetal rats. Immunocytochemistry, flow cytometry, and immunohistochemistry were applied to evaluate DJ-1 expression in proliferating NSCs. We found that DJ-1 was co-expressed with nestin, a marker of progenitors, during NSC proliferation from days 1-7. The present results suggest that DJ-1 is co-expressed with nestin in NSCs during proliferation.

语种英语
所属项目编号2004CB518902
资助者National Program for Key Basic Research ; National Program for Key Basic Research
WOS记录号WOS:000273167800004
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51234
专题北京大学药学院
作者单位1.Peking Univ, State Key Res Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Dept Mol & Cellular Pharmacol, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
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Yan, Hui,Pu, Xiao-Ping. Expression of the Parkinson′s Disease-Related Protein DJ-1 during Neural Stem Cell Proliferation[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2010,33(1):18-21.
APA Yan, Hui,&Pu, Xiao-Ping.(2010).Expression of the Parkinson′s Disease-Related Protein DJ-1 during Neural Stem Cell Proliferation.BIOLOGICAL & PHARMACEUTICAL BULLETIN,33(1),18-21.
MLA Yan, Hui,et al."Expression of the Parkinson′s Disease-Related Protein DJ-1 during Neural Stem Cell Proliferation".BIOLOGICAL & PHARMACEUTICAL BULLETIN 33.1(2010):18-21.
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