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学科主题: 药学
题名:
Expression of the Parkinson′s Disease-Related Protein DJ-1 during Neural Stem Cell Proliferation
作者: Yan, Hui1,2; Pu, Xiao-Ping1,2
关键词: neural stem cell ; DJ-1 ; nestin ; proliferation ; Parkinson&prime ; s disease
刊名: BIOLOGICAL & PHARMACEUTICAL BULLETIN
发表日期: 2010
卷: 33, 期:1, 页:18-21
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: PATHOGENESIS ; MUTATIONS ; PROSPECTS ; NEURONS ; STRESS ; ALPHA ; MODEL
英文摘要:

Neural stem cells (NSCs) arise through neurogenesis, and comprise all newly-formed neurons in the central and peripheral nervous systems. DJ-1 is associated with autosomal recessive familial Parkinson′s disease (PD). The relationship between DJ-1 and NSC proliferation may shed light on the underlying pathogenesis of, and potential treatments for, PD. To investigate the relationship between DJ-1 and NSCs, embryonic cortical NSCs were isolated and cultured from E14 fetal rats. Immunocytochemistry, flow cytometry, and immunohistochemistry were applied to evaluate DJ-1 expression in proliferating NSCs. We found that DJ-1 was co-expressed with nestin, a marker of progenitors, during NSC proliferation from days 1-7. The present results suggest that DJ-1 is co-expressed with nestin in NSCs during proliferation.

语种: 英语
所属项目编号: 2004CB518902
项目资助者: National Program for Key Basic Research
WOS记录号: WOS:000273167800004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51234
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, State Key Res Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Dept Mol & Cellular Pharmacol, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Yan, Hui,Pu, Xiao-Ping. Expression of the Parkinson′s Disease-Related Protein DJ-1 during Neural Stem Cell Proliferation[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2010,33(1):18-21.
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