IR@PKUHSC  > 北京大学第一临床医学院  > 胸外科
学科主题临床医学
Surgical treatment of IIIb-T-4 lung cancer invading left atrium and great vessels
Wang Xiao-xin1; Liu Tong-lin1; Yin Xing-ru2
关键词Lung Neoplasms Surgical Procedures Pulmonary Artery Vena Cava Neoplasm Invasiveness Superior
刊名CHINESE MEDICAL JOURNAL
2010-02-05
DOI10.3760/cma.j.issn.0366-6999.2010.03.002
123期:3页:265-268
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]SUPERIOR VENA-CAVA ; NONSMALL ; RESECTION ; EXPERIENCE ; SURVIVAL
英文摘要

Background IIIb-T-4 non-small cell lung cancer (NSCLC) is commonly considered a contraindication to surgery, although chemo-radiotherapy also achieves a poor survival rate. We reviewed our experience with T-4 NSCLC patients who underwent surgery to explore the indications and prognostic factors of surgical treatment of lung cancer invading the left atrium and great vessels.

Methods We investigated a cohort of 105 patients, 79 men and 26 women, who underwent surgery from May 1996 to July 2008. Their pathological staging was T4N0-M-2(0). The median age was 59 years, ranging from 36 to 75 years. Patients were grouped based on invading sites: tumors invading the left atrium (LA group), tumors invading the superior vena cava (SVC group), and tumors invading the intrapericardial pulmonary artery (PA group). Patients were further characterized based upon the type of operation, complete resection and incomplete resection groups, and on the lymph node pathological status, N-0, N-1 and N-2 groups. We calculated the overall five-year survival rate.

Results All patients received resection of primary lesions, with partial resection of the left atrium in the LA group (n=25), angioplasty of superior vena cava in the SVC group (n=23) and intrapericardial ligation of the pulmonary artery in the PA group (n=57). Complete resection was possible in 77 patients (73.3%). The overall survival rate of the 105 patients was 41.0% at 5 years; 36.0% for the LA group, 34.8% for the SVC group and 45.6% for the PA group. Pathological N status significantly influenced the overall 5-year survival rate; 61.5% for N-0, 51.1% for the N-1 and 11.8% for the N-2 groups (N-2 group versus N-0 group, P < 0.0001, N-2 versus N-1 group, P < 0.0001). Surgical resection also influenced survival; 49.4% for the complete resection group and 17.9% for the incomplete resection group (P < 0.0001). Cox regression analysis demonstrated that pathological N status was a significant independent predictor of prognosis.

Conclusions Pathological N status is a significant independent predictor for survival of patients with IIIb-T-4 lung cancer invading the left atrium and great vessels. The completeness of resection has a significant influence on the overall 5-year survival rate. Surgery for T-4 lung cancer may be effective in patients without mediastinal lymph node involvement. Chin Med J 2010;123(3)265-268

语种英语
WOS记录号WOS:000274753400002
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51235
专题北京大学第一临床医学院_胸外科
作者单位1.Peking Univ, Hosp 1, Dept Thorac Surg, Beijing 100034, Peoples R China
2.Fifth Peoples Hosp Dalian, Dept Thorac Surg, Dalian 116021, Liaoning, Peoples R China
推荐引用方式
GB/T 7714
Wang Xiao-xin,Liu Tong-lin,Yin Xing-ru. Surgical treatment of IIIb-T-4 lung cancer invading left atrium and great vessels[J]. CHINESE MEDICAL JOURNAL,2010,123(3):265-268.
APA Wang Xiao-xin,Liu Tong-lin,&Yin Xing-ru.(2010).Surgical treatment of IIIb-T-4 lung cancer invading left atrium and great vessels.CHINESE MEDICAL JOURNAL,123(3),265-268.
MLA Wang Xiao-xin,et al."Surgical treatment of IIIb-T-4 lung cancer invading left atrium and great vessels".CHINESE MEDICAL JOURNAL 123.3(2010):265-268.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang Xiao-xin]的文章
[Liu Tong-lin]的文章
[Yin Xing-ru]的文章
百度学术
百度学术中相似的文章
[Wang Xiao-xin]的文章
[Liu Tong-lin]的文章
[Yin Xing-ru]的文章
必应学术
必应学术中相似的文章
[Wang Xiao-xin]的文章
[Liu Tong-lin]的文章
[Yin Xing-ru]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。