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学科主题: 临床医学
题名:
Impact of hydrogen sulfide on carbon monoxide/heme oxygenase pathway in the pathogenesis of hypoxic pulmonary hypertension
作者: Zhang, QY1; Du, JB1; Zhou, WJ1; Yan, H1; Tang, CS1; Zhang, CY1
关键词: hydrogen sulfides carbon rnonoxide heine oxygenase ; hypoxia hypertension ; pulmonary
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2004-04-23
DOI: 10.1016/j.bbrc.2004.02.176
卷: 317, 期:1, 页:30-37
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: SMOOTH-MUSCLE-CELLS ; NITRIC-OXIDE ; GENE-EXPRESSION ; PROLIFERATION ; RATS ; H2S
英文摘要:

Hypoxic pulmonary hypertension (HPH) is an important pathophysiological process of a variety of cardiac and pulmonary diseases. But the mechanisms responsible for HPH are still not fully understood. The discoveries of endogenous gas signal molecules, nitric oxide (NO), and carbon monoxide (CO), have been moving the research of HPH to a new phase. Hydrogen sulfide (H2S), which is now being considered as the third new gas transmitter, was found to be possibly involved in the pathogenesis of HPH. But whether there exists an interaction between H2S and CO has not been clear in the pathogenesis of HPH. In this Study, we found that H2S was significantly decreased in the pathogenesis of HPH. However, plasma CO level and the expressions of heme oxygenase (HO-1) protein and HO-1 mRNA were significantly increased. Exogenous Supply of H2S could alleviate the elevation of pulmonary arterial pressure. At the same time, plasma CO level and the expressions of HO-1 protein and mRNA in pulmonary arteries were significantly increased. Whereas, exogenous supply of propargylglycine (PPG), an inhibitor of cystathionine gamma-lyase (CSE), decreased the plasma HS content and worsened HPH. At the same time, plasma CO level and the expressions of HO-1 protein and mRNA in pulmonary arteries were decreased. The results showed that H,S Could play a regulatory role in the pathogenesis of HPH through up-regulating COMO pathway. (C) 2004 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000220725700004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51237
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Peking Univ, Dept Pediat, Hosp 1, Beijing 10034, Peoples R China
2.Peking Univ, Inst Cardiovasc Res, Hosp 1, Beijing 10034, Peoples R China

Recommended Citation:
Zhang, QY,Du, JB,Zhou, WJ,et al. Impact of hydrogen sulfide on carbon monoxide/heme oxygenase pathway in the pathogenesis of hypoxic pulmonary hypertension[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2004,317(1):30-37.
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