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Impact of hydrogen sulfide on carbon monoxide/heme oxygenase pathway in the pathogenesis of hypoxic pulmonary hypertension
Zhang, QY1; Du, JB1; Zhou, WJ1; Yan, H1; Tang, CS1; Zhang, CY1
关键词Hydrogen Sulfides Carbon Rnonoxide Heine Oxygenase Hypoxia Hypertension Pulmonary
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2004-04-23
DOI10.1016/j.bbrc.2004.02.176
317期:1页:30-37
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]SMOOTH-MUSCLE-CELLS ; NITRIC-OXIDE ; GENE-EXPRESSION ; PROLIFERATION ; RATS ; H2S
英文摘要

Hypoxic pulmonary hypertension (HPH) is an important pathophysiological process of a variety of cardiac and pulmonary diseases. But the mechanisms responsible for HPH are still not fully understood. The discoveries of endogenous gas signal molecules, nitric oxide (NO), and carbon monoxide (CO), have been moving the research of HPH to a new phase. Hydrogen sulfide (H2S), which is now being considered as the third new gas transmitter, was found to be possibly involved in the pathogenesis of HPH. But whether there exists an interaction between H2S and CO has not been clear in the pathogenesis of HPH. In this Study, we found that H2S was significantly decreased in the pathogenesis of HPH. However, plasma CO level and the expressions of heme oxygenase (HO-1) protein and HO-1 mRNA were significantly increased. Exogenous Supply of H2S could alleviate the elevation of pulmonary arterial pressure. At the same time, plasma CO level and the expressions of HO-1 protein and mRNA in pulmonary arteries were significantly increased. Whereas, exogenous supply of propargylglycine (PPG), an inhibitor of cystathionine gamma-lyase (CSE), decreased the plasma HS content and worsened HPH. At the same time, plasma CO level and the expressions of HO-1 protein and mRNA in pulmonary arteries were decreased. The results showed that H,S Could play a regulatory role in the pathogenesis of HPH through up-regulating COMO pathway. (C) 2004 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000220725700004
引用统计
被引频次:96[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51237
专题北京大学第一临床医学院_儿科
作者单位1.Peking Univ, Dept Pediat, Hosp 1, Beijing 10034, Peoples R China
2.Peking Univ, Inst Cardiovasc Res, Hosp 1, Beijing 10034, Peoples R China
推荐引用方式
GB/T 7714
Zhang, QY,Du, JB,Zhou, WJ,et al. Impact of hydrogen sulfide on carbon monoxide/heme oxygenase pathway in the pathogenesis of hypoxic pulmonary hypertension[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2004,317(1):30-37.
APA Zhang, QY,Du, JB,Zhou, WJ,Yan, H,Tang, CS,&Zhang, CY.(2004).Impact of hydrogen sulfide on carbon monoxide/heme oxygenase pathway in the pathogenesis of hypoxic pulmonary hypertension.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,317(1),30-37.
MLA Zhang, QY,et al."Impact of hydrogen sulfide on carbon monoxide/heme oxygenase pathway in the pathogenesis of hypoxic pulmonary hypertension".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 317.1(2004):30-37.
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