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学科主题: 精神卫生
题名:
Striatal neuronal loss or dysfunction and choline rise in children with attention-deficit hyperactivity disorder: a H-1-magnetic resonance spectroscopy study
作者: Jin, Z1; Zang, YF1; Zeng, YW1; Zhang, L1; Wang, YF1
关键词: attention-deficit hyperactivity disorder ; children ; magnetic resonance spectroscopy ; striatum ; N-acetylaspartate ; choline
刊名: NEUROSCIENCE LETTERS
发表日期: 2001-11-23
卷: 315, 期:1-2, 页:45-48
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: BASAL GANGLIA ; DEFICIT/HYPERACTIVITY DISORDER ; MRI ; ADULTS
英文摘要:

Twelve previously untreated boys suffering from attention-deficit hyperactivity disorder (ADHD) were investigated by using proton magnetic resonance spectroscopy (H-1 MRS) before and after one dose (10 mg) of methylphenidate. Pre- and post-methylphenidate spectra were acquired bilaterally in the globus pallidus. Peaks of N-acetylaspartate (NAA), choline (Cho), myo-inositol, glutamate and creatine (Cr) were measured and the ratios of the peaks were calculated and compared with data from ten matched controls. In children having ADHD, NAA/Cr ratio decreased significantly in the bilateral striatum while Cho/Cr ratio showed a mild unilateral increase. One oral dose of methylphenidate did not affect the ratios significantly. These findings suggest that the striatum was bilaterally involved in pediatric ADHD patients. Approximately 20-25% of neurons may have died or may be severely dysfunctional. There seems to be a mild hyperactivity of the cholinergic system. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000172434800012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51244
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Hosp 306, Ctr FMRI, Beijing 100101, Peoples R China
2.Hosp 306, Dept Radiol, Beijing 100101, Peoples R China
3.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China

Recommended Citation:
Jin, Z,Zang, YF,Zeng, YW,et al. Striatal neuronal loss or dysfunction and choline rise in children with attention-deficit hyperactivity disorder: a H-1-magnetic resonance spectroscopy study[J]. NEUROSCIENCE LETTERS,2001,315(1-2):45-48.
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