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Striatal neuronal loss or dysfunction and choline rise in children with attention-deficit hyperactivity disorder: a H-1-magnetic resonance spectroscopy study
Jin, Z1; Zang, YF1; Zeng, YW1; Zhang, L1; Wang, YF1
关键词Attention-deficit Hyperactivity Disorder Children Magnetic Resonance Spectroscopy Striatum N-acetylaspartate Choline
刊名NEUROSCIENCE LETTERS
2001-11-23
315期:1-2页:45-48
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]BASAL GANGLIA ; DEFICIT/HYPERACTIVITY DISORDER ; MRI ; ADULTS
英文摘要

Twelve previously untreated boys suffering from attention-deficit hyperactivity disorder (ADHD) were investigated by using proton magnetic resonance spectroscopy (H-1 MRS) before and after one dose (10 mg) of methylphenidate. Pre- and post-methylphenidate spectra were acquired bilaterally in the globus pallidus. Peaks of N-acetylaspartate (NAA), choline (Cho), myo-inositol, glutamate and creatine (Cr) were measured and the ratios of the peaks were calculated and compared with data from ten matched controls. In children having ADHD, NAA/Cr ratio decreased significantly in the bilateral striatum while Cho/Cr ratio showed a mild unilateral increase. One oral dose of methylphenidate did not affect the ratios significantly. These findings suggest that the striatum was bilaterally involved in pediatric ADHD patients. Approximately 20-25% of neurons may have died or may be severely dysfunctional. There seems to be a mild hyperactivity of the cholinergic system. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000172434800012
引用统计
被引频次:59[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51244
专题北京大学精神卫生研究所
作者单位1.Hosp 306, Ctr FMRI, Beijing 100101, Peoples R China
2.Hosp 306, Dept Radiol, Beijing 100101, Peoples R China
3.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Jin, Z,Zang, YF,Zeng, YW,et al. Striatal neuronal loss or dysfunction and choline rise in children with attention-deficit hyperactivity disorder: a H-1-magnetic resonance spectroscopy study[J]. NEUROSCIENCE LETTERS,2001,315(1-2):45-48.
APA Jin, Z,Zang, YF,Zeng, YW,Zhang, L,&Wang, YF.(2001).Striatal neuronal loss or dysfunction and choline rise in children with attention-deficit hyperactivity disorder: a H-1-magnetic resonance spectroscopy study.NEUROSCIENCE LETTERS,315(1-2),45-48.
MLA Jin, Z,et al."Striatal neuronal loss or dysfunction and choline rise in children with attention-deficit hyperactivity disorder: a H-1-magnetic resonance spectroscopy study".NEUROSCIENCE LETTERS 315.1-2(2001):45-48.
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