北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学精神卫生研究所  > 期刊论文
学科主题: 精神卫生
题名:
Striatal neuronal loss or dysfunction and choline rise in children with attention-deficit hyperactivity disorder: a H-1-magnetic resonance spectroscopy study
作者: Jin, Z1; Zang, YF1; Zeng, YW1; Zhang, L1; Wang, YF1
关键词: attention-deficit hyperactivity disorder ; children ; magnetic resonance spectroscopy ; striatum ; N-acetylaspartate ; choline
刊名: NEUROSCIENCE LETTERS
发表日期: 2001-11-23
卷: 315, 期:1-2, 页:45-48
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: BASAL GANGLIA ; DEFICIT/HYPERACTIVITY DISORDER ; MRI ; ADULTS
英文摘要:

Twelve previously untreated boys suffering from attention-deficit hyperactivity disorder (ADHD) were investigated by using proton magnetic resonance spectroscopy (H-1 MRS) before and after one dose (10 mg) of methylphenidate. Pre- and post-methylphenidate spectra were acquired bilaterally in the globus pallidus. Peaks of N-acetylaspartate (NAA), choline (Cho), myo-inositol, glutamate and creatine (Cr) were measured and the ratios of the peaks were calculated and compared with data from ten matched controls. In children having ADHD, NAA/Cr ratio decreased significantly in the bilateral striatum while Cho/Cr ratio showed a mild unilateral increase. One oral dose of methylphenidate did not affect the ratios significantly. These findings suggest that the striatum was bilaterally involved in pediatric ADHD patients. Approximately 20-25% of neurons may have died or may be severely dysfunctional. There seems to be a mild hyperactivity of the cholinergic system. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000172434800012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51244
Appears in Collections:北京大学精神卫生研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Hosp 306, Ctr FMRI, Beijing 100101, Peoples R China
2.Hosp 306, Dept Radiol, Beijing 100101, Peoples R China
3.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China

Recommended Citation:
Jin, Z,Zang, YF,Zeng, YW,et al. Striatal neuronal loss or dysfunction and choline rise in children with attention-deficit hyperactivity disorder: a H-1-magnetic resonance spectroscopy study[J]. NEUROSCIENCE LETTERS,2001,315(1-2):45-48.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Jin, Z]'s Articles
[Zang, YF]'s Articles
[Zeng, YW]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Jin, Z]‘s Articles
[Zang, YF]‘s Articles
[Zeng, YW]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace