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学科主题: 药学
题名:
Novel mechanism of ethaselen in poorly differentiated colorectal RKO cell growth inhibition: Simultaneous regulation of TrxR transcription, expression and enzyme activity
作者: Yin, Hanwei2,3; Li, Jing1,2; Xiong, Kun3; Wang, Lihui1,2; Wang, Tianyu3; Tan, Qiang1,4; Fu, Jianing1,2; Ren, Xiaoyuan1,2; Zeng, Huihui1,2
关键词: Thioredoxin reductase ; Ethaselen ; RKO cell ; LoVo cell ; Poorly differentiated ; Wnt/beta-catenin
刊名: DIFFERENTIATION
发表日期: 2011
DOI: 10.1016/j.diff.2010.09.180
卷: 81, 期:1, 页:49-56
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Developmental Biology
研究领域[WOS]: Cell Biology ; Developmental Biology
关键词[WOS]: THIOREDOXIN REDUCTASE INHIBITOR ; CANCER STEM-CELLS ; BETA-CATENIN ; PROGENITOR CELLS ; TGF-BETA ; IN-VITRO ; APOPTOSIS ; PROTEIN ; GENE ; LINES
英文摘要:

Thioredoxin reductase (TrxR) is a ubiquitous intracellular redox enzyme that regulates tumor growth and proliferation in various cancer cells. Ethaselen (1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]-ethane), a novel anticancer agent, is designed to target mammalian TrxR1 with the aims of cancer growth inhibition and TrxR inactivation. In this study, we demonstrated that ethaselen significantly inhibits cell growth in the poorly differentiated colorectal RKO cell line, and simultaneously downregulates mammalian TrxR1 mRNA transcript levels, protein expression and enzyme activity, which differs from its actions in moderately differentiated colorectal LoVo cells. Ethaselen′s significant abatement of the Wnt/beta-catenin cell differentiation-related signaling pathway was also observed in RKO cells; this apparently leads to its strong inhibitory effect on cell growth and TrxR1 activity in this cell line. These results suggest that ethaselen has a novel mechanism affecting cell growth in the poorly differentiated RKO colorectal cell line. (c) 2010 International Society of Differentiation. Published by Elsevier Ltd. All rights reserved.

语种: 英语
项目资助者: State Key Laboratory of Natural and Biomimetic Drugs
WOS记录号: WOS:000284826700006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51247
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Peking Univ, Coll Life Sci, Beijing 100075, Peoples R China
4.Peking Univ First Hosp, Beijing 100034, Peoples R China

Recommended Citation:
Yin, Hanwei,Li, Jing,Xiong, Kun,et al. Novel mechanism of ethaselen in poorly differentiated colorectal RKO cell growth inhibition: Simultaneous regulation of TrxR transcription, expression and enzyme activity[J]. DIFFERENTIATION,2011,81(1):49-56.
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