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学科主题: 临床医学
题名:
Large liver tumors: Protocol for radiofrequency ablation and its clinical application in 110 patients - Mathematic model, overlapping mode, and electrode placement process
作者: Chen, MH1; Yang, W1; Yan, K1; Zou, MW1; Solbiati, L1; Liu, LB1; Dai, Y1
关键词: liver neoplasms ; liver neoplasms, CT ; liver neoplasms, US ; model, mathematical ; radiofrequency (RF) ablation
刊名: RADIOLOGY
发表日期: 2004-07-01
DOI: 10.1148/radiol.2321030821
卷: 232, 期:1, 页:260-271
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: TRANSCATHETER ARTERIAL EMBOLIZATION ; THERMAL ABLATION ; HEPATOCELLULAR-CARCINOMA ; TISSUE ABLATION ; HEPATIC METASTASES ; COLORECTAL-CANCER ; FOLLOW-UP ; OCCLUSION ; LESIONS ; SIZE
英文摘要:

PURPOSE: To establish a preoperative protocol for ultrasonographically guided percutaneous radiofrequency (RF) ablation of large liver tumors that is based on mathematic models and clinical experience and to evaluate the role of this protocol in RF ablation.

MATERIALS AND METHODS: A regular prism and a regular polyhedron model were used to develop a preoperative protocol for liver tumor ablation. This protocol enabled the authors to minimize the number of ablation spheres, optimize the overlapping mode, and determine the electrode placement process. One hundred ten patients with 121 liver tumors were treated by using this protocol. Sixty-nine patients had 74 hepatocellular carcinomas (HCCs), and 41 had 47 metastases to the liver (ie, metastatic liver carcinomas [MLCs]). Patients underwent follow-up helical computed tomography (CT) 1 month and every 2-3 months after RF ablation. Ablation was considered a success if no contrast enhancement was detected in the treated area on the CT scan obtained at 1 month.

RESULTS: A total of 536 ablations were performed in the 121 tumors. The ablation success rate was 87.6% (106 of 121 tumors); the local recurrence rate, 24.0% (29 of 121 tumors); and the estimated mean recurrence-free survival, 17.1 months. Twenty-five patients underwent 38 re-treatments for local tumor recurrence. Major complications occurred in seven patients. Of these patients, only one, who had a tumor close to the colon, had a colon perforation 1 week after RF and required surgical intervention.

CONCLUSION: The described protocol for treatment of large tumors had a success rate of 87.6% and a local recurrence rate of 24.0%. (C) RSNA, 2004.

语种: 英语
WOS记录号: WOS:000222161300036
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51248
Appears in Collections:北京大学临床肿瘤学院_超声科_期刊论文

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作者单位: 1.Peking Univ, Sch Clin Oncol, Dept Ultrasound, Beijing 100036, Hai Dian Distri, Peoples R China
2.Osped Gen, Dept Radiol, Busto Arsizio, Italy
3.Capital Normal Univ, High Sch, Dept Math, Beijing, Peoples R China
4.Thomas Jefferson Univ Hosp, Dept Radiol, Philadelphia, PA 19107 USA

Recommended Citation:
Chen, MH,Yang, W,Yan, K,et al. Large liver tumors: Protocol for radiofrequency ablation and its clinical application in 110 patients - Mathematic model, overlapping mode, and electrode placement process[J]. RADIOLOGY,2004,232(1):260-271.
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