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Sex-specific association of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and plasma BDNF with attention-deficit/hyperactivity disorder in a drug-naive Han Chinese sample
Li, Haimei1,2; Liu, Lu1,2; Tang, Yilang3; Ji, Ning1,2; Yang, Li1,2; Qian, Qiujin1,2; Wang, Yufeng1,2
关键词Bdnf Adhd Sex-specific Association Plasma Polymorphism
刊名PSYCHIATRY RESEARCH
2014-07-30
DOI10.1016/j.psychres.2014.03.011
217期:3页:191-197
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Psychiatry
研究领域[WOS]Psychiatry
关键词[WOS]DEFICIT-HYPERACTIVITY DISORDER ; HEALTHY-HUMAN SUBJECTS ; FACTOR GENE ; HUMAN PLATELETS ; MET ALLELE ; SERUM ; CHILDREN ; ADHD ; SCHIZOPHRENIA ; AGE
英文摘要

A functional polymorphism of the brain derived neurotrophic factor gene (BDNF) (Val66Met) has been suggested to be involved in the pathogenesis of attention-deficit/hyperactivity disorder (ADHD). It also has an impact on peripheral BDNF levels in psychiatric disorders. This study examined the association of Val66Met with plasma BDNF level of ADHD in Han Chinese children (170 medication - naive ADHD patients and 155 unaffected controls, aged 6-16 years). The Val allele was showed a higher frequency in females with ADHD (n=84) than controls (P=0.029) from the case-control association study. The analysis of covariance (ANCOVA) indicated that the mean plasma BDNF levels of ADHD patients were significantly higher than that of controls (P=0.001). We performed both total sample and sex stratified analyses to investigate the effect of Val66Met genotype on the plasma BDNF levels, but only a trend of association was found in females with ADHD (n=84), with a tendency of lower plasma BDNF level in Val allele carriers than Met/Met genotype carriers (P=0.071). Our results suggested a sex-specific association between BDNF and ADHD. Furthermore, there was a possible sex-specific relationship between the BDNF Val66Met genotype and plasma BDNF levels. However, further studies are required to elucidate the role of BDNF in ADHD. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000336878400011
项目编号973 program 2014CB846104 ; 81071109 ; 81301171 ; NCET-11-0013
资助机构National Basic Research Development Program of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51252
专题北京大学精神卫生研究所
北京大学精神卫生研究所_精神科
作者单位1.Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA
2.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
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GB/T 7714
Li, Haimei,Liu, Lu,Tang, Yilang,et al. Sex-specific association of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and plasma BDNF with attention-deficit/hyperactivity disorder in a drug-naive Han Chinese sample[J]. PSYCHIATRY RESEARCH,2014,217(3):191-197.
APA Li, Haimei.,Liu, Lu.,Tang, Yilang.,Ji, Ning.,Yang, Li.,...&Wang, Yufeng.(2014).Sex-specific association of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and plasma BDNF with attention-deficit/hyperactivity disorder in a drug-naive Han Chinese sample.PSYCHIATRY RESEARCH,217(3),191-197.
MLA Li, Haimei,et al."Sex-specific association of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and plasma BDNF with attention-deficit/hyperactivity disorder in a drug-naive Han Chinese sample".PSYCHIATRY RESEARCH 217.3(2014):191-197.
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