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学科主题: 精神卫生
题名:
Sex-specific association of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and plasma BDNF with attention-deficit/hyperactivity disorder in a drug-naive Han Chinese sample
作者: Li, Haimei1,2; Liu, Lu1,2; Tang, Yilang3; Ji, Ning1,2; Yang, Li1,2; Qian, Qiujin1,2; Wang, Yufeng1,2
关键词: BDNF ; ADHD ; Sex-specific ; Association ; Plasma ; Polymorphism
刊名: PSYCHIATRY RESEARCH
发表日期: 2014-07-30
DOI: 10.1016/j.psychres.2014.03.011
卷: 217, 期:3, 页:191-197
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Psychiatry
研究领域[WOS]: Psychiatry
关键词[WOS]: DEFICIT-HYPERACTIVITY DISORDER ; HEALTHY-HUMAN SUBJECTS ; FACTOR GENE ; HUMAN PLATELETS ; MET ALLELE ; SERUM ; CHILDREN ; ADHD ; SCHIZOPHRENIA ; AGE
英文摘要:

A functional polymorphism of the brain derived neurotrophic factor gene (BDNF) (Val66Met) has been suggested to be involved in the pathogenesis of attention-deficit/hyperactivity disorder (ADHD). It also has an impact on peripheral BDNF levels in psychiatric disorders. This study examined the association of Val66Met with plasma BDNF level of ADHD in Han Chinese children (170 medication - naive ADHD patients and 155 unaffected controls, aged 6-16 years). The Val allele was showed a higher frequency in females with ADHD (n=84) than controls (P=0.029) from the case-control association study. The analysis of covariance (ANCOVA) indicated that the mean plasma BDNF levels of ADHD patients were significantly higher than that of controls (P=0.001). We performed both total sample and sex stratified analyses to investigate the effect of Val66Met genotype on the plasma BDNF levels, but only a trend of association was found in females with ADHD (n=84), with a tendency of lower plasma BDNF level in Val allele carriers than Met/Met genotype carriers (P=0.071). Our results suggested a sex-specific association between BDNF and ADHD. Furthermore, there was a possible sex-specific relationship between the BDNF Val66Met genotype and plasma BDNF levels. However, further studies are required to elucidate the role of BDNF in ADHD. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 973 program 2014CB846104 ; 81071109 ; 81301171 ; NCET-11-0013
项目资助者: National Basic Research Development Program of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University
WOS记录号: WOS:000336878400011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51252
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA
2.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China

Recommended Citation:
Li, Haimei,Liu, Lu,Tang, Yilang,et al. Sex-specific association of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and plasma BDNF with attention-deficit/hyperactivity disorder in a drug-naive Han Chinese sample[J]. PSYCHIATRY RESEARCH,2014,217(3):191-197.
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