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Preparation of t-butyidimethylsiloxyphenyl boronic acids and hydroxyphenylboronic acids
Chao Jian-Ping1; Wu Wen-Qiong1; Luo Xuan-De1; Ling Yang-Zhi1
关键词Hydroxyphenylboronic Acid T-butyldimethylsiloxyphenylboronic Acid Grignard Reagent Preparation
刊名CHINESE JOURNAL OF ORGANIC CHEMISTRY
2006-07-01
26期:7页:1004-1007
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]DERIVATIVES
英文摘要

p-, m- and o-bromophenols were first protected by t-butyldimethylchlorosilane, and then treated with Mg to form Grignard reagents. After reaction with tributylborate and selective hydrolysis, three t-butyldimethylsiloxy phenylboronic acids were obtained in yields 51% (p), 44% (m) and 40% (o), respectively. If dibutyl p- or m-siloxyphenylborate intermediates were hydrolyzed in strong acid, p or m-hydroxyphenylboronic acids were achieved with yields of 14% and 65% respectively. But these hydroxyphenylboronic acids were difficult to purify because the impurity hydroxyphenol was always formed spontaneously.

语种中文
WOS记录号WOS:000238905100024
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51257
专题北京大学药学院
北京大学药学院_药物化学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Natl Inst Pharmaceut Res & Dev, Beijing 100226, Peoples R China
推荐引用方式
GB/T 7714
Chao Jian-Ping,Wu Wen-Qiong,Luo Xuan-De,et al. Preparation of t-butyidimethylsiloxyphenyl boronic acids and hydroxyphenylboronic acids[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2006,26(7):1004-1007.
APA Chao Jian-Ping,Wu Wen-Qiong,Luo Xuan-De,&Ling Yang-Zhi.(2006).Preparation of t-butyidimethylsiloxyphenyl boronic acids and hydroxyphenylboronic acids.CHINESE JOURNAL OF ORGANIC CHEMISTRY,26(7),1004-1007.
MLA Chao Jian-Ping,et al."Preparation of t-butyidimethylsiloxyphenyl boronic acids and hydroxyphenylboronic acids".CHINESE JOURNAL OF ORGANIC CHEMISTRY 26.7(2006):1004-1007.
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