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学科主题: 药学
题名:
Preparation of t-butyidimethylsiloxyphenyl boronic acids and hydroxyphenylboronic acids
作者: Chao Jian-Ping1; Wu Wen-Qiong1; Luo Xuan-De1; Ling Yang-Zhi1
关键词: hydroxyphenylboronic acid ; t-butyldimethylsiloxyphenylboronic acid ; Grignard reagent ; preparation
刊名: CHINESE JOURNAL OF ORGANIC CHEMISTRY
发表日期: 2006-07-01
卷: 26, 期:7, 页:1004-1007
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: DERIVATIVES
英文摘要:

p-, m- and o-bromophenols were first protected by t-butyldimethylchlorosilane, and then treated with Mg to form Grignard reagents. After reaction with tributylborate and selective hydrolysis, three t-butyldimethylsiloxy phenylboronic acids were obtained in yields 51% (p), 44% (m) and 40% (o), respectively. If dibutyl p- or m-siloxyphenylborate intermediates were hydrolyzed in strong acid, p or m-hydroxyphenylboronic acids were achieved with yields of 14% and 65% respectively. But these hydroxyphenylboronic acids were difficult to purify because the impurity hydroxyphenol was always formed spontaneously.

语种: 中文
WOS记录号: WOS:000238905100024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51257
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Natl Inst Pharmaceut Res & Dev, Beijing 100226, Peoples R China

Recommended Citation:
Chao Jian-Ping,Wu Wen-Qiong,Luo Xuan-De,et al. Preparation of t-butyidimethylsiloxyphenyl boronic acids and hydroxyphenylboronic acids[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2006,26(7):1004-1007.
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