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学科主题: 临床医学
题名:
Clinicopathological and prognostic significance of programmed cell death ligand1 (PD-L1) expression in patients with non-small cell lung cancer: a meta-analysis
作者: Pan, Zhen-Kui1; Ye, Feng2; Wu, Xuan3; An, Han-Xiang2; Wu, Jing-Xun2
关键词: Meta-analysis ; non-small cell lung cancer (NSCLC) ; programmed cell death ligand 1 (PD-L1) ; prognosis
刊名: JOURNAL OF THORACIC DISEASE
发表日期: 2015-03-01
DOI: 10.3978/j.issn.2072-1439.2015.02.13
卷: 7, 期:3, 页:462-470
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Respiratory System
研究领域[WOS]: Respiratory System
关键词[WOS]: TUMOR-IMMUNOTHERAPY ; IMMUNE EVASION ; B7-H1 ; BLOCKADE ; ADENOCARCINOMA ; MUTATIONS ; TOLERANCE ; MECHANISM ; ANTIBODY ; SAFETY
英文摘要:

Objective: Programmed cell death 1 (PD-1) and one of its ligands, PD-L1, are key immune checkpoint proteins. Evidences showed PD-L1 is an emerging biomarker for immunotherapy by anti-PD-1 and anti-PD-L1 antibody in non-small cell lung cancer (NSCLC). To investigate the association of PD-L1 protein expression with clinicopathological features and its impact on survival outcome, we conducted a meta-analysis.

Methods: A comprehensive literature search of electronic databases (up to July 10, 2014) was performed. Correlation between PD-L1 expression and clinicopathological features and overall survival (OS) was analyzed by synthesizing the qualified data. Publication biases were examined.

Results: A total of 1,550 NSCLC patients from 9 studies were included. The pooled odds ratios (ORs) indicated high PD-L1 expression was associated with poor tumor differentiation [OR = 0.53, 95% confidence interval (CI): 0.39-0.72, P<0.0001]. Whereas, none of other clinicopathological characteristics [gender, smoking status, histological type, invasive depth of tumor, status of lymph node metastasis and tumor node metastasis (TNM) stage] were correlated with PD-L1 expression in current analysis. The combined hazard ratio (HR) for OS showed high expression of PD-L1 impaired the OS in NSCLC (HRpositive/negative = 1.47, 95% CI: 1.19-1.83, P=0.0004).

Conclusions: Our meta-analysis indicated PD-L1 protein expression in NSCLC was not associated with common clinicopathological characteristics, except tumor differentiation. It was a poor prognostic biomarker for NSCLC. Further research should be performed to investigate the precise clinicopathological and prognostic significance of PD-L1 in NSCLC under uniform testing standard.

语种: 英语
WOS记录号: WOS:000353054200053
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51262
Appears in Collections:北京大学临床肿瘤学院_肿瘤内科_期刊论文

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作者单位: 1.Qingdao Municipal Hosp, Dept Oncol, Qingdao 266011, Peoples R China
2.Xiamen Univ, Affiliated Hosp 1, Dept Med Oncol, Xiamen 361003, Peoples R China
3.Peking Univ Shenzhen Hosp, Dept Med Oncol, Shenzhen 518036, Peoples R China

Recommended Citation:
Pan, Zhen-Kui,Ye, Feng,Wu, Xuan,et al. Clinicopathological and prognostic significance of programmed cell death ligand1 (PD-L1) expression in patients with non-small cell lung cancer: a meta-analysis[J]. JOURNAL OF THORACIC DISEASE,2015,7(3):462-470.
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