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学科主题: 基础医学
题名:
Epithelial-to-Mesenchymal Transition in Renal Neoplasms
作者: He, Huiying1; Magi-Galluzzi, Cristina2
关键词: EMT ; renal cell carcinoma ; sarcomatoid differentiation
刊名: ADVANCES IN ANATOMIC PATHOLOGY
发表日期: 2014-05-01
DOI: 10.1097/PAP.0000000000000018
卷: 21, 期:3, 页:174-180
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: CELL CARCINOMA-CELLS ; SARCOMATOID DIFFERENTIATION ; CANCER-CELLS ; E-CADHERIN ; EXPRESSION ; INVASION ; DEDIFFERENTIATION ; PROGRESSION ; METASTASIS ; MICRORNAS
英文摘要:

Epithelial-to-mesenchymal transition (EMT) describes a phenotypical change induced in epithelial cells that lose their cell-cell basement membrane contacts and their structural polarity to become spindle-shaped and morphologically similar to mesenchymal/myofibroblast cell. The abnormal induction of EMT has been demonstrated to contribute to cancer dissemination and progression. Renal cell carcinoma (RCC) with sarcomatoid differentiation (sarcomatoid RCC) represents a good example of EMT both morphologically and immunohistochemically. Early spindle cell changes can at times be identified in RCC and likely represent an early step toward EMT. Herein, we present a review of the current understanding of EMT in renal neoplasms including some known signaling regulation, the association of sarcomatoid differentiation in RCC with aggressive behavior and dismal prognosis, and EMT-related tumor biology in sarcomatoid RCC. A better perception of the EMT may contribute toward an improved understanding of the development of sarcomatoid RCC. In addition, a distinct signature for sarcomatoid RCC may have utility in the differential diagnosis for prognostic stratification as well as in identifying novel genes and pathway targets for therapeutic intervention.

语种: 英语
WOS记录号: WOS:000334790300004
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51268
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100871, Peoples R China
2.Cleveland Clin, Dept Pathol, RT Pathol & Lab Med Inst, Cleveland, OH 44195 USA

Recommended Citation:
He, Huiying,Magi-Galluzzi, Cristina. Epithelial-to-Mesenchymal Transition in Renal Neoplasms[J]. ADVANCES IN ANATOMIC PATHOLOGY,2014,21(3):174-180.
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