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学科主题基础医学
Epithelial-to-Mesenchymal Transition in Renal Neoplasms
He, Huiying1; Magi-Galluzzi, Cristina2
关键词EMT renal cell carcinoma sarcomatoid differentiation
刊名ADVANCES IN ANATOMIC PATHOLOGY
2014-05-01
DOI10.1097/PAP.0000000000000018
21期:3页:174-180
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Pathology
研究领域[WOS]Pathology
关键词[WOS]CELL CARCINOMA-CELLS ; SARCOMATOID DIFFERENTIATION ; CANCER-CELLS ; E-CADHERIN ; EXPRESSION ; INVASION ; DEDIFFERENTIATION ; PROGRESSION ; METASTASIS ; MICRORNAS
英文摘要

Epithelial-to-mesenchymal transition (EMT) describes a phenotypical change induced in epithelial cells that lose their cell-cell basement membrane contacts and their structural polarity to become spindle-shaped and morphologically similar to mesenchymal/myofibroblast cell. The abnormal induction of EMT has been demonstrated to contribute to cancer dissemination and progression. Renal cell carcinoma (RCC) with sarcomatoid differentiation (sarcomatoid RCC) represents a good example of EMT both morphologically and immunohistochemically. Early spindle cell changes can at times be identified in RCC and likely represent an early step toward EMT. Herein, we present a review of the current understanding of EMT in renal neoplasms including some known signaling regulation, the association of sarcomatoid differentiation in RCC with aggressive behavior and dismal prognosis, and EMT-related tumor biology in sarcomatoid RCC. A better perception of the EMT may contribute toward an improved understanding of the development of sarcomatoid RCC. In addition, a distinct signature for sarcomatoid RCC may have utility in the differential diagnosis for prognostic stratification as well as in identifying novel genes and pathway targets for therapeutic intervention.

语种英语
WOS记录号WOS:000334790300004
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被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51268
专题北京大学基础医学院_病理学系
北京大学基础医学院
作者单位1.Peking Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100871, Peoples R China
2.Cleveland Clin, Dept Pathol, RT Pathol & Lab Med Inst, Cleveland, OH 44195 USA
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He, Huiying,Magi-Galluzzi, Cristina. Epithelial-to-Mesenchymal Transition in Renal Neoplasms[J]. ADVANCES IN ANATOMIC PATHOLOGY,2014,21(3):174-180.
APA He, Huiying,&Magi-Galluzzi, Cristina.(2014).Epithelial-to-Mesenchymal Transition in Renal Neoplasms.ADVANCES IN ANATOMIC PATHOLOGY,21(3),174-180.
MLA He, Huiying,et al."Epithelial-to-Mesenchymal Transition in Renal Neoplasms".ADVANCES IN ANATOMIC PATHOLOGY 21.3(2014):174-180.
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