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学科主题: 药学
题名:
Two flavonoids from the leaves of Morus alba induce differentiation of the human promyelocytic leukemia (HL-60) cell line
作者: Kim, SY1; Gao, JJ1; Kang, K1
关键词: mulberry leaf ; flavonoid ; differentiation
刊名: BIOLOGICAL & PHARMACEUTICAL BULLETIN
发表日期: 2000-04-01
卷: 23, 期:4, 页:451-455
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: SUSPENSION CULTURE ; HYDROGEN-PEROXIDE ; INTERFERON-GAMMA ; PHORBOL DIESTER ; U937 CELLS ; COMPONENTS ; EXPRESSION ; ACID
英文摘要:

Two flavonoids, quercetin-3-O-beta-D-glucopyranoside (1) and quercetin-3,7-di-O-beta-D-glucopyranoside (2), were isolated from the leaves of Morus alba (Moraceae). These two flavonoids exerted a significant inhibitory effect on the growth of the human promyelocytic leukemia cell line (HL-60) at the concentration of 2 x 10(-4) M. Compound 2 also induced differentiation of the HL-60 cell line to express CD 66b and CD 14 antigens, These flavonoids exhibited significant free radical scavenging effects on 1,1-diphenyl-2-pieryl-hydrazyl radical.

语种: 英语
WOS记录号: WOS:000086315500016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51275
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Cheju Natl Univ, Sch Med, Cheju 690756, South Korea
2.Kyung Hee Univ, Grad Sch EW Med Sci, Seoul 130701, South Korea
3.Beijing Med Univ, Sch Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Kim, SY,Gao, JJ,Kang, K. Two flavonoids from the leaves of Morus alba induce differentiation of the human promyelocytic leukemia (HL-60) cell line[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2000,23(4):451-455.
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