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IR@PKUHSC  > 北京大学第二临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Efficacy and safety of aliskiren, a direct renin inhibitor, compared with ramipril in Asian patients with mild to moderate hypertension
作者: Zhu, Jun-Ren1; Sun, Ning-Ling2; Yang, Kan3; Hu, Jian4; Xu, Geng5; Hong, Huashan6; Wang, Ruonan7; Tu, Ying-Mei7; Ritter, Shannon8; Keefe, Deborah8; Trial Investigators1
关键词: aliskiren ; Asian ; cough ; ramipril
刊名: HYPERTENSION RESEARCH
发表日期: 2012
DOI: 10.1038/hr.2011.150
卷: 35, 期:1, 页:28-33
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: ANGIOTENSIN-CONVERTING-ENZYME ; PLACEBO-LIKE TOLERABILITY ; DOSE-DEPENDENT EFFICACY ; ANTIHYPERTENSIVE EFFICACY ; JAPANESE PATIENTS ; PREVALENCE ; COUGH ; CHINESE ; GUIDELINES ; TRIAL
英文摘要:

This 8-week, randomized, double-blind, parallel-group study compared the efficacy and safety of aliskiren with ramipril in Asian patients with mild to moderate hypertension. Following a 2- to 3-week placebo run-in period, patients with mean sitting diastolic blood pressure (msDBP) >= 95 and <110 mm Hg were randomized to receive once daily dose of either aliskiren 75, 150, 300mg or ramipril 5mg for 8 weeks. Efficacy variables were the changes in msDBP and mean sitting systolic BP (msSBP) and BP control rates (<140/90 mm Hg). Safety was assessed by recording adverse events (AEs) and serious AEs (SAEs). Of 1316 randomized patients, 1160 (88.1%) completed the study. At the study endpoint, patients on aliskiren had greater mean BP reductions (14.39/11.63 mm Hg for 300 mg; 12.16/10.04 mm Hg for 150 mg; 12.24/10.66 mm Hg for 75 mg) than those on 5mg ramipril (11.46/9.19 mm Hg). All aliskiren doses were statistically non-inferior (P<0.0001) to ramipril in reducing msDBP. The reduction in BP for aliskiren 300 mg was statistically superior vs. ramipril (P<0.002). Blood pressure control rates were higher for aliskiren (300 mg, 52.29%; 150 mg, 48.11%; 75 mg, 45.68%) than for ramipril (5 mg, 43.7%); the difference for aliskiren 300 mg vs. ramipril 5mg was statistically significant (P<0.05). Aliskiren was well tolerated with a fourfold lower incidence of cough (0.6-1.2%) compared with ramipril (5.2%). SAEs were rare in this study (0.5%). Aliskiren produced greater BP reductions with a lower incidence of cough than ramipril in Asian patients with mild to moderate hypertension. Hypertension Research (2012) 35, 28-33; doi:10.1038/hr.2011.150; published online 8 September 2011

语种: 英语
项目资助者: Novartis Pharma AG, Basel, Switzerland
WOS记录号: WOS:000299168900007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51276
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Novartis Pharmaceut, E Hanover, NJ USA
2.Fudan Univ, Zhongshan Hosp, Dept Cardiol, Shanghai 200032, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100871, Peoples R China
4.Cent S Univ, Xiangya Hosp 3, Dept Cardiol, Changsha, Hunan, Peoples R China
5.China Med Univ, Affiliated Hosp 1, Dept Cardiol, Shenyang, Peoples R China
6.Zhejiang Univ, Coll Med, Affiliated Hosp 2, Dept Cardiol, Hangzhou 310003, Zhejiang, Peoples R China
7.Fujian Med Univ, Union Hosp, Dept Cardiol, Fuzhou, Peoples R China
8.Beijing Novartis Pharma Co Ltd, Dept Cardiol, Beijing, Peoples R China

Recommended Citation:
Zhu, Jun-Ren,Sun, Ning-Ling,Yang, Kan,et al. Efficacy and safety of aliskiren, a direct renin inhibitor, compared with ramipril in Asian patients with mild to moderate hypertension[J]. HYPERTENSION RESEARCH,2012,35(1):28-33.
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