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Cannabinoid CB(1) receptor antagonist rimonabant disrupts nicotine reward-associated memory in rats
Fang, Qin1,2; Li, Fang-Qiong1,2; Li, Yan-Qin3; Xue, Yan-Xue3; He, Ying-Ying1,2; Liu, Jian-Feng3; Lu, Lin3; Wang, Ji-Shi1,2
关键词Nicotine Cannabinoid Cb(1) Receptor Antagonist Conditioned Place Preference Reconsolidation Reinstatement Memory
刊名PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
2011-10-01
DOI10.1016/j.pbb.2011.06.019
99期:4页:738-742
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]CONDITIONED PLACE PREFERENCE ; MESOLIMBIC DOPAMINERGIC SYSTEM ; PROTEIN-SYNTHESIS ; SQUIRREL-MONKEYS ; SEEKING BEHAVIOR ; COCAINE-SEEKING ; RECONSOLIDATION ; ADDICTION ; MORPHINE ; REINSTATEMENT
英文摘要

Exposure to cues previously associated with drug intake leads to relapse by activating previously acquired memories. Based on previous findings, in which cannabinoid CB(1) receptors were found to be critically involved in specific aspects of learning and memory, we investigated the role of CB(1) receptors in nicotine reward memory using a rat conditioned place preference (CPP) model. In Experiment 1, rats were trained for CPP with alternating injections of nicotine (0.5 mg/kg, s.c.) and saline to acquire the nicotine-conditioned memory. To examine the effects of rimonabant on the reconsolidation of nicotine reward memory, rats were administered rimonabant (0, 0.3, and 3.0 mg/kg, i.p.) immediately after reexposure to the drug-paired context. In Experiment 2, rats were trained for CPP similarly to Experiment 1. To examine the effects of rimonabant on the reinstatement of nicotine reward memory, rimonabant (0, 0.3, and 3.0 mg/kg. i.p.) was administered before the test of nicotine-induced CPP reinstatement. In Experiment 3, to evaluate whether rimonabant itself produces a reward memory, rats were trained for CPP with alternating injections of different doses of rimonabant (0, 0.3, and 3.0 mg/kg) and saline. Rimonabant at a dose of 3.0 mg/kg significantly disrupted the reconsolidation of nicotine memory and significantly blocked the reinstatement of nicotine-induced CPP. However, rimonabant itself did not produce CPP. These findings provide clear evidence that CB(1) receptors play a role in nicotine reward memory, suggesting that CB(1) receptor antagonists may be a potential target for managing nicotine addiction. (C) 2011 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000294880100031
项目编号2007CB512302 ; 2008-59
资助机构National Basic Research Program of China (973 Program) ; Natural Science Foundation of Guizhou Province
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51282
专题中国药物依赖性研究所
作者单位1.Guiyang Med Univ, Sch Pharm, Guiyang 550004, Peoples R China
2.Guiyang Med Univ, Affiliated Hosp, Guiyang 550004, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Fang, Qin,Li, Fang-Qiong,Li, Yan-Qin,et al. Cannabinoid CB(1) receptor antagonist rimonabant disrupts nicotine reward-associated memory in rats[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2011,99(4):738-742.
APA Fang, Qin.,Li, Fang-Qiong.,Li, Yan-Qin.,Xue, Yan-Xue.,He, Ying-Ying.,...&Wang, Ji-Shi.(2011).Cannabinoid CB(1) receptor antagonist rimonabant disrupts nicotine reward-associated memory in rats.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,99(4),738-742.
MLA Fang, Qin,et al."Cannabinoid CB(1) receptor antagonist rimonabant disrupts nicotine reward-associated memory in rats".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 99.4(2011):738-742.
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