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学科主题: 药物依赖
题名:
Cannabinoid CB(1) receptor antagonist rimonabant disrupts nicotine reward-associated memory in rats
作者: Fang, Qin1,2; Li, Fang-Qiong1,2; Li, Yan-Qin3; Xue, Yan-Xue3; He, Ying-Ying1,2; Liu, Jian-Feng3; Lu, Lin3; Wang, Ji-Shi1,2
关键词: Nicotine ; Cannabinoid CB(1) receptor antagonist ; Conditioned place preference ; Reconsolidation ; Reinstatement ; Memory
刊名: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
发表日期: 2011-10-01
DOI: 10.1016/j.pbb.2011.06.019
卷: 99, 期:4, 页:738-742
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]: CONDITIONED PLACE PREFERENCE ; MESOLIMBIC DOPAMINERGIC SYSTEM ; PROTEIN-SYNTHESIS ; SQUIRREL-MONKEYS ; SEEKING BEHAVIOR ; COCAINE-SEEKING ; RECONSOLIDATION ; ADDICTION ; MORPHINE ; REINSTATEMENT
英文摘要:

Exposure to cues previously associated with drug intake leads to relapse by activating previously acquired memories. Based on previous findings, in which cannabinoid CB(1) receptors were found to be critically involved in specific aspects of learning and memory, we investigated the role of CB(1) receptors in nicotine reward memory using a rat conditioned place preference (CPP) model. In Experiment 1, rats were trained for CPP with alternating injections of nicotine (0.5 mg/kg, s.c.) and saline to acquire the nicotine-conditioned memory. To examine the effects of rimonabant on the reconsolidation of nicotine reward memory, rats were administered rimonabant (0, 0.3, and 3.0 mg/kg, i.p.) immediately after reexposure to the drug-paired context. In Experiment 2, rats were trained for CPP similarly to Experiment 1. To examine the effects of rimonabant on the reinstatement of nicotine reward memory, rimonabant (0, 0.3, and 3.0 mg/kg. i.p.) was administered before the test of nicotine-induced CPP reinstatement. In Experiment 3, to evaluate whether rimonabant itself produces a reward memory, rats were trained for CPP with alternating injections of different doses of rimonabant (0, 0.3, and 3.0 mg/kg) and saline. Rimonabant at a dose of 3.0 mg/kg significantly disrupted the reconsolidation of nicotine memory and significantly blocked the reinstatement of nicotine-induced CPP. However, rimonabant itself did not produce CPP. These findings provide clear evidence that CB(1) receptors play a role in nicotine reward memory, suggesting that CB(1) receptor antagonists may be a potential target for managing nicotine addiction. (C) 2011 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2007CB512302 ; 2008-59
项目资助者: National Basic Research Program of China (973 Program) ; Natural Science Foundation of Guizhou Province
WOS记录号: WOS:000294880100031
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51282
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Guiyang Med Univ, Sch Pharm, Guiyang 550004, Peoples R China
2.Guiyang Med Univ, Affiliated Hosp, Guiyang 550004, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China

Recommended Citation:
Fang, Qin,Li, Fang-Qiong,Li, Yan-Qin,et al. Cannabinoid CB(1) receptor antagonist rimonabant disrupts nicotine reward-associated memory in rats[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2011,99(4):738-742.
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