北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 解剖学与组织胚胎学系  > 期刊论文
学科主题: 基础医学
题名:
Kindlin 2 promotes breast cancer invasion via epigenetic silencing of the microRNA200 gene family
作者: Yu, Yu1,2,3,4; Wu, Junzhou1,2,3,4; Guan, Lizhao1,2,3,4; Qi, Lihua1,2,3,4; Tang, Yan1,2,3,4; Ma, Bo1,2,3,4; Zhan, Jun1,2,3,4; Wang, Yunling1; Fang, Weigang1,5; Zhang, Hongquan1,2,3,4
关键词: breast cancer ; DNA methyltransferase ; Kindlins ; MicroRNA-200 family
刊名: INTERNATIONAL JOURNAL OF CANCER
发表日期: 2013-09-15
DOI: 10.1002/ijc.28151
卷: 133, 期:6, 页:1368-1379
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: MITOGEN-INDUCIBLE GENE-2 ; MIR-200 FAMILY ; MESENCHYMAL TRANSITION ; DNA METHYLTRANSFERASE ; MIRNA PROMOTERS ; CELL INVASION ; ZEB1 ; METHYLATION ; EXPRESSION ; IDENTIFICATION
英文摘要:

Kindlin 2, as a focal adhesion protein, controls integrin activation and regulates Wnt signaling in an integrin-binding independent manner. However, the association of Kindlin 2 with cancer-related microRNAs is unknown. Here, we report that Kindlin 2 markedly downregulates the expression of miR-200 family by inducing CpG island hypermethylation. Mechanistically, Kindlin 2 forms a complex with DNMT3A in the cell nucleus and the two proteins co-occupy the promoter of miRNA-200b. Functionally, repression of miR-200b is required for Kindlin 2-induced breast cancer cell invasion and tumor formation. Our data indicate that Kindlin 2 plays a novel role in epigenetic repression of miR-200 family, a mechanism that promotes breast cancer invasion.

What′s new? Recent studies have implicated Kindlin 2, a focal adhesion protein, in boosting tumor progression. This study investigated the association of Kindlin 2 with microRNAs (miRNAs), which are frequently altered in cancer. The authors showed that Kindlin 2 forms a complex with DNA methyltransferase 3A, and this complex then blocks the miR-200b promoter. MicroRNAs in the miR-200 family function as tumor repressors, and their loss is crucial for cell invasion and tumor progression. These new results demonstrate for the first time that Kindlin 2 promotes breast cancer invasion by working together with DNA methyltransferase 3A to stifle miR-200b expression.

语种: 英语
所属项目编号: 2010CB912203 ; 2010CB529402 ; 30830048 ; 81230051 ; 31170711 ; 81101495 ; 7120002 ; BMU20120314
项目资助者: Ministry of Science and Technology of China ; National Natural Science Foundation of China ; 111 Project of the Ministry of Education ; Beijing Natural Science Foundation ; Peking University ; Leading Academic Discipline Project of Beijing Education Bureau
WOS记录号: WOS:000321436300010
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51285
Appears in Collections:基础医学院_解剖学与组织胚胎学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
Kindlin 2 promotes breast cancer invasion via epigenetic silencing of the microRNA200 gene family.pdf(926KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Peking Univ, Hlth Sci Ctr, Minist Educ China, Key Lab Carcinogenesis & Translat Res, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Lab Mol Cell Biol & Tumor Biol, Dept Anat, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Histol, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Embryol, Beijing 100191, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China

Recommended Citation:
Yu, Yu,Wu, Junzhou,Guan, Lizhao,et al. Kindlin 2 promotes breast cancer invasion via epigenetic silencing of the microRNA200 gene family[J]. INTERNATIONAL JOURNAL OF CANCER,2013,133(6):1368-1379.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yu, Yu]'s Articles
[Wu, Junzhou]'s Articles
[Guan, Lizhao]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yu, Yu]‘s Articles
[Wu, Junzhou]‘s Articles
[Guan, Lizhao]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace