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学科主题临床医学
Characteristics of urinary tract infection pathogens and their in vitro susceptibility to antimicrobial agents in China: data from a multicenter study
Qiao, Lu-Dong1; Chen, Shan1; Yang, Yong2; Zhang, Kai3; Zheng, Bo4; Guo, Hong-Feng5; Yang, Bo6; Niu, Yuan-Jie7; Wang, Yi8; Shi, Ben-Kang9; Yang, Wei-Min10; Zhao, Xiao-Kun11; Gao, Xiao-Feng12; Chen, Ming13; Tian, Ye14
刊名BMJ OPEN
2013
DOI10.1136/bmjopen-2013-004152
3期:12
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]STAPHYLOCOCCUS-EPIDERMIDIS BIOFILMS ; COAGULASE-NEGATIVE STAPHYLOCOCCI ; WOMEN ; DISEASE
英文摘要

Objective: This study assessed the characteristics of pathogens identified in clinical isolates from patients with urinary tract infection (UTI) and their in vitro sensitivity to commonly used antibiotics in the clinical setting in China.

Design and setting: Multicenter study was conducted between January and December 2011 in 12 hospitals in China.

Participants: Urine samples were collected from 356 symptomatic patients treated in the study hospitals for acute uncomplicated cystitis, recurrent UTI or complicated UTI.

Primary and secondary outcome measures: Minimal inhibitory concentrations (MICs) were measured using broth microdilution according to the Clinical and Laboratory Standards Institute 2011 guidelines. Thirteen antimicrobial agents were tested: fosfomycin tromethamine, levofloxacin, moxifloxacin, cefdinir, cefixime, cefaclor, cefprozil, cefuroxime, amoxicillin/clavulanic acid, cefotaxime, azithromycin, nitrofurantoin and oxacillin. Escherichia coli isolates were screened and extended spectrum beta-lactamases (ESBL) production was confirmed by a double-disk synergy test.

Results: 198 urine samples were culture-positive and 175 isolates were included in the final analysis. E coli was detected in 50% of cultures, followed by Staphylococcus epidermidis (9%), Enterococcus faecalis (9%) and Klebsiella pneumoniae (5%). The detection rate of ESBL-producing E coli was 53%. Resistance to levofloxacin was the most common among all the isolates. Nitrofurantoin and fosfomycin tromethamine had the greatest activity against E coli; overall, 92% and 91% of isolates were susceptible to these antimicrobials. E faecalis had the highest susceptibility rates to fosfomycin tromethamine (100%).

Conclusions: The most frequently identified pathogens in our patients were ESBL-producing E coli and E faecalis. Fosfomycin tromethamine and nitrofurantoin showed a good antimicrobial activity against UTI pathogens. They may represent good options for the empiric treatment of patients with UTI.

语种英语
WOS记录号WOS:000330541400067
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51286
专题北京大学临床肿瘤学院_泌尿外科
北京大学第二临床医学院_泌尿外科
作者单位1.Peking Univ, Hosp 1, Dept Urol, Beijing 100871, Peoples R China
2.Hubei Tongji Hosp, Dept Urol, Wuhan, Peoples R China
3.Hunan Xiangya Second Hosp, Dept Urol, Changsha, Hunan, Peoples R China
4.Beijing Canc Hosp, Dept Urol, Beijing, Peoples R China
5.Capital Med Univ, Beijing Tongren Hosp, Dept Urol, Beijing, Peoples R China
6.Peking Univ, Hosp 1, Inst Clin Pharmacol, Beijing 100871, Peoples R China
7.Peking Univ, Shougang Hosp, Jieping Wu Urol Ctr, Dept Urol, Beijing 100871, Peoples R China
8.Peking Univ, Peoples Hosp, Dept Urol, Beijing 100871, Peoples R China
9.Tianjin Med Univ, Affiliated Hosp 2, Dept Urol, Tianjin, Peoples R China
10.China Med Univ, Affiliated Hosp 1, Dept Urol, Shenyang, Peoples R China
11.Shandong Univ, Qilu Hosp, Dept Urol, Jinan 250100, Peoples R China
12.Shanghai Changhai Hosp, Dept Urol, Shanghai, Peoples R China
13.Southeast Univ, Zhongda Hosp, Dept Urol, Nanjing, Jiangsu, Peoples R China
14.Capital Med Univ, Beijing Friendship Hosp, Dept Urol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Qiao, Lu-Dong,Chen, Shan,Yang, Yong,et al. Characteristics of urinary tract infection pathogens and their in vitro susceptibility to antimicrobial agents in China: data from a multicenter study[J]. BMJ OPEN,2013,3(12).
APA Qiao, Lu-Dong.,Chen, Shan.,Yang, Yong.,Zhang, Kai.,Zheng, Bo.,...&Tian, Ye.(2013).Characteristics of urinary tract infection pathogens and their in vitro susceptibility to antimicrobial agents in China: data from a multicenter study.BMJ OPEN,3(12).
MLA Qiao, Lu-Dong,et al."Characteristics of urinary tract infection pathogens and their in vitro susceptibility to antimicrobial agents in China: data from a multicenter study".BMJ OPEN 3.12(2013).
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