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学科主题: 临床医学
题名:
Characteristics of urinary tract infection pathogens and their in vitro susceptibility to antimicrobial agents in China: data from a multicenter study
作者: Qiao, Lu-Dong1; Chen, Shan1; Yang, Yong2; Zhang, Kai3; Zheng, Bo4; Guo, Hong-Feng5; Yang, Bo6; Niu, Yuan-Jie7; Wang, Yi8; Shi, Ben-Kang9; Yang, Wei-Min10; Zhao, Xiao-Kun11; Gao, Xiao-Feng12; Chen, Ming13; Tian, Ye14
刊名: BMJ OPEN
发表日期: 2013
DOI: 10.1136/bmjopen-2013-004152
卷: 3, 期:12
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: STAPHYLOCOCCUS-EPIDERMIDIS BIOFILMS ; COAGULASE-NEGATIVE STAPHYLOCOCCI ; WOMEN ; DISEASE
英文摘要:

Objective: This study assessed the characteristics of pathogens identified in clinical isolates from patients with urinary tract infection (UTI) and their in vitro sensitivity to commonly used antibiotics in the clinical setting in China.

Design and setting: Multicenter study was conducted between January and December 2011 in 12 hospitals in China.

Participants: Urine samples were collected from 356 symptomatic patients treated in the study hospitals for acute uncomplicated cystitis, recurrent UTI or complicated UTI.

Primary and secondary outcome measures: Minimal inhibitory concentrations (MICs) were measured using broth microdilution according to the Clinical and Laboratory Standards Institute 2011 guidelines. Thirteen antimicrobial agents were tested: fosfomycin tromethamine, levofloxacin, moxifloxacin, cefdinir, cefixime, cefaclor, cefprozil, cefuroxime, amoxicillin/clavulanic acid, cefotaxime, azithromycin, nitrofurantoin and oxacillin. Escherichia coli isolates were screened and extended spectrum beta-lactamases (ESBL) production was confirmed by a double-disk synergy test.

Results: 198 urine samples were culture-positive and 175 isolates were included in the final analysis. E coli was detected in 50% of cultures, followed by Staphylococcus epidermidis (9%), Enterococcus faecalis (9%) and Klebsiella pneumoniae (5%). The detection rate of ESBL-producing E coli was 53%. Resistance to levofloxacin was the most common among all the isolates. Nitrofurantoin and fosfomycin tromethamine had the greatest activity against E coli; overall, 92% and 91% of isolates were susceptible to these antimicrobials. E faecalis had the highest susceptibility rates to fosfomycin tromethamine (100%).

Conclusions: The most frequently identified pathogens in our patients were ESBL-producing E coli and E faecalis. Fosfomycin tromethamine and nitrofurantoin showed a good antimicrobial activity against UTI pathogens. They may represent good options for the empiric treatment of patients with UTI.

语种: 英语
WOS记录号: WOS:000330541400067
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51286
Appears in Collections:北京大学临床肿瘤学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Urol, Beijing 100871, Peoples R China
2.Hubei Tongji Hosp, Dept Urol, Wuhan, Peoples R China
3.Hunan Xiangya Second Hosp, Dept Urol, Changsha, Hunan, Peoples R China
4.Beijing Canc Hosp, Dept Urol, Beijing, Peoples R China
5.Capital Med Univ, Beijing Tongren Hosp, Dept Urol, Beijing, Peoples R China
6.Peking Univ, Hosp 1, Inst Clin Pharmacol, Beijing 100871, Peoples R China
7.Peking Univ, Shougang Hosp, Jieping Wu Urol Ctr, Dept Urol, Beijing 100871, Peoples R China
8.Peking Univ, Peoples Hosp, Dept Urol, Beijing 100871, Peoples R China
9.Tianjin Med Univ, Affiliated Hosp 2, Dept Urol, Tianjin, Peoples R China
10.China Med Univ, Affiliated Hosp 1, Dept Urol, Shenyang, Peoples R China
11.Shandong Univ, Qilu Hosp, Dept Urol, Jinan 250100, Peoples R China
12.Shanghai Changhai Hosp, Dept Urol, Shanghai, Peoples R China
13.Southeast Univ, Zhongda Hosp, Dept Urol, Nanjing, Jiangsu, Peoples R China
14.Capital Med Univ, Beijing Friendship Hosp, Dept Urol, Beijing, Peoples R China

Recommended Citation:
Qiao, Lu-Dong,Chen, Shan,Yang, Yong,et al. Characteristics of urinary tract infection pathogens and their in vitro susceptibility to antimicrobial agents in China: data from a multicenter study[J]. BMJ OPEN,2013,3(12).
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