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A new hypothesis of sex-differences in temporomandibular disorders: Estrogen enhances hyperalgesia of inflamed TMJ through modulating voltage-gated sodium channel 1.7 in trigeminal ganglion?
Bi, Rui-Yun1; Ding, Yun1; Gan, Ye-Hua2,3
刊名MEDICAL HYPOTHESES
2015-02-01
DOI10.1016/j.mehy.2014.12.010
84期:2页:100-103
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]INFLAMMATORY PAIN ; RECEPTOR ; NA(V)1.7 ; JOINT ; SCN9A ; RAT ; NEURONS ; ACTIVATION ; EXPRESSION ; ALLODYNIA
英文摘要

Objective: Temporomandibular disorders (TMD) are an assorted set of clinical conditions characterized mainly by pain in the temporomandibular joint (TMJ). TMJ inflammation or synovitis is frequently observed in TMD patients and is the major reason for TMD pain. TMD is prevalent in women of childbearing age, at least twice than in men, implying that estrogen may be involved in TMD pain processing. Estrogen affects a cell mainly through the estrogen receptors (ER). The estrogen-ER complex binds to estrogen response element sequences (ERE) in the promoter region of specific genes and then exerts its regulatory potential. The voltage-gated sodium channel 1.7 (Nav1.7), whose single disruption leads to a complete loss of pain, amplifies weak stimuli in the neurons and acts as the threshold channel for firing action potentials and plays a prominent role in pain perception, including inflammatory pain. Furthermore, our previous study showed that trigeminal ganglionic Nav1.7 was involved in the hyperalgesia of the inflamed TMJ. We propose that estrogen may enhance hyperalgesia of inflamed TMJ through decrease nociceptive threshold of TMJ or inflamed TMJ by modulating both expression and channel threshold of Nav1.7 in trigeminal ganglion. (c) 2014 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000349507200005
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51289
专题北京大学口腔医学院
北京大学口腔医学院_中心实验室
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dent Ctr 3, Beijing 100088, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Cent Lab, Beijing 100088, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Ctr Temporomandibular Disorders & Orofacial Pain, Beijing 100088, Peoples R China
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GB/T 7714
Bi, Rui-Yun,Ding, Yun,Gan, Ye-Hua. A new hypothesis of sex-differences in temporomandibular disorders: Estrogen enhances hyperalgesia of inflamed TMJ through modulating voltage-gated sodium channel 1.7 in trigeminal ganglion?[J]. MEDICAL HYPOTHESES,2015,84(2):100-103.
APA Bi, Rui-Yun,Ding, Yun,&Gan, Ye-Hua.(2015).A new hypothesis of sex-differences in temporomandibular disorders: Estrogen enhances hyperalgesia of inflamed TMJ through modulating voltage-gated sodium channel 1.7 in trigeminal ganglion?.MEDICAL HYPOTHESES,84(2),100-103.
MLA Bi, Rui-Yun,et al."A new hypothesis of sex-differences in temporomandibular disorders: Estrogen enhances hyperalgesia of inflamed TMJ through modulating voltage-gated sodium channel 1.7 in trigeminal ganglion?".MEDICAL HYPOTHESES 84.2(2015):100-103.
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