|Relationship between LAPTM4B gene polymorphism and susceptibility of primary liver cancer|
|Wang, S.1; Zhang, Q-Y1; Zhou, R-L2|
|关键词||Gene Polymorphism Laptm4b Primary Liver Cancer Susceptibility|
|刊名||ANNALS OF ONCOLOGY|
|WOS标题词||Science & Technology|
|关键词[WOS]||INDEPENDENT PROGNOSTIC MARKER ; HEPATOCELLULAR-CARCINOMA ; RISK-FACTORS ; OVEREXPRESSION ; PROGRESSION ; EXPRESSION ; PROTEIN|
Lysosome associated protein transmembrane 4 beta (LAPTM4B) was identified first as a novel gene overexpressed in human hepatocellular carcinoma. LAPTM4B*1 and LAPTM4B*2 are two alleles of the gene; they are differentiated at 5′UTR in the first exon. Allele *1 contains only one copy of a 19-bp sequence in the 5′UTR. However, allele *2 contains another identical 19-bp sequence following the first one tightly. In this case-control study, we aimed to identify the relationship between LAPTM4B gene polymorphism and the susceptibility of primary liver cancer.
The case-control study was conducted in China, including 303 primary liver cancer cases and 515 controls. LAPTM4B gene polymorphism was determined by PCR. Statistical analysis includes odds ratio (OR) and 95% confidence interval (CI) calculations using unconditional logistic regression.
We found a significant difference in the frequency of LAPTM4B*2 between cases and controls (P < 0.05). Our study showed that LAPTM4B*1/2 and *2/2 were associated with a significantly increased risk of primary liver cancer compared with LAPTM4B*1/1 (OR = 1.898, 95% CI = 1.387-2.598 and OR = 2.483, 95% CI = 1.480-4.168, respectively). The genotypes of LAPTM4B in this study have negative correlation with the clinicopathologicals observed.
The evidences suggest that gene polymorphism of LAPTM4B may influence the individuals′ susceptibility to primary liver cancer and allele *2 being considered as a potential risk factor.
|项目编号||81071422 ; 7041003 ; 5072016|
|资助机构||National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation, Beijing, China|
|作者单位||1.Peking Univ, Dept Clin Lab, Key Lab Carcinogenesis & Translat Res, Minist Educ,Sch Oncol,Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China|
2.Peking Univ, Dept Cell Biol & Genet, Sch Basic Med Sci, Beijing 100142, Peoples R China
|Wang, S.,Zhang, Q-Y,Zhou, R-L. Relationship between LAPTM4B gene polymorphism and susceptibility of primary liver cancer[J]. ANNALS OF ONCOLOGY,2012,23(7):1864-1869.|
|APA||Wang, S.,Zhang, Q-Y,&Zhou, R-L.(2012).Relationship between LAPTM4B gene polymorphism and susceptibility of primary liver cancer.ANNALS OF ONCOLOGY,23(7),1864-1869.|
|MLA||Wang, S.,et al."Relationship between LAPTM4B gene polymorphism and susceptibility of primary liver cancer".ANNALS OF ONCOLOGY 23.7(2012):1864-1869.|