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学科主题临床医学
Relationship between LAPTM4B gene polymorphism and susceptibility of primary liver cancer
Wang, S.1; Zhang, Q-Y1; Zhou, R-L2
关键词Gene Polymorphism Laptm4b Primary Liver Cancer Susceptibility
刊名ANNALS OF ONCOLOGY
2012-07-01
DOI10.1093/annonc/mdr538
23期:7页:1864-1869
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]INDEPENDENT PROGNOSTIC MARKER ; HEPATOCELLULAR-CARCINOMA ; RISK-FACTORS ; OVEREXPRESSION ; PROGRESSION ; EXPRESSION ; PROTEIN
英文摘要

Lysosome associated protein transmembrane 4 beta (LAPTM4B) was identified first as a novel gene overexpressed in human hepatocellular carcinoma. LAPTM4B*1 and LAPTM4B*2 are two alleles of the gene; they are differentiated at 5′UTR in the first exon. Allele *1 contains only one copy of a 19-bp sequence in the 5′UTR. However, allele *2 contains another identical 19-bp sequence following the first one tightly. In this case-control study, we aimed to identify the relationship between LAPTM4B gene polymorphism and the susceptibility of primary liver cancer.

The case-control study was conducted in China, including 303 primary liver cancer cases and 515 controls. LAPTM4B gene polymorphism was determined by PCR. Statistical analysis includes odds ratio (OR) and 95% confidence interval (CI) calculations using unconditional logistic regression.

We found a significant difference in the frequency of LAPTM4B*2 between cases and controls (P < 0.05). Our study showed that LAPTM4B*1/2 and *2/2 were associated with a significantly increased risk of primary liver cancer compared with LAPTM4B*1/1 (OR = 1.898, 95% CI = 1.387-2.598 and OR = 2.483, 95% CI = 1.480-4.168, respectively). The genotypes of LAPTM4B in this study have negative correlation with the clinicopathologicals observed.

The evidences suggest that gene polymorphism of LAPTM4B may influence the individuals′ susceptibility to primary liver cancer and allele *2 being considered as a potential risk factor.

语种英语
WOS记录号WOS:000306135200032
项目编号81071422 ; 7041003 ; 5072016
资助机构National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Natural Science Foundation, Beijing, China
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51290
专题北京大学临床肿瘤学院_临床实验室
作者单位1.Peking Univ, Dept Clin Lab, Key Lab Carcinogenesis & Translat Res, Minist Educ,Sch Oncol,Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China
2.Peking Univ, Dept Cell Biol & Genet, Sch Basic Med Sci, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Wang, S.,Zhang, Q-Y,Zhou, R-L. Relationship between LAPTM4B gene polymorphism and susceptibility of primary liver cancer[J]. ANNALS OF ONCOLOGY,2012,23(7):1864-1869.
APA Wang, S.,Zhang, Q-Y,&Zhou, R-L.(2012).Relationship between LAPTM4B gene polymorphism and susceptibility of primary liver cancer.ANNALS OF ONCOLOGY,23(7),1864-1869.
MLA Wang, S.,et al."Relationship between LAPTM4B gene polymorphism and susceptibility of primary liver cancer".ANNALS OF ONCOLOGY 23.7(2012):1864-1869.
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