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学科主题: 临床医学
题名:
In vitro antifungal activity of ZJ-522, a new triazole restructured from fluconazole and butenatine, against clinically important fungi in comparison with fluconazole and butenatine
作者: Gao, PH1; Cao, YB1; Xu, Z1; Zhang, JD1; Zhang, WN1; Wang, Y1; Gu, J1; Cao, YY1; Li, RY1; Jia, XM1; Jiang, YY1
关键词: ZJ-522 ; fluconazole ; butenafine ; antifungal activity ; MIC
刊名: BIOLOGICAL & PHARMACEUTICAL BULLETIN
发表日期: 2005-08-01
卷: 28, 期:8, 页:1414-1417
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: UNITED-STATES ; CANDIDA-ALBICANS ; SECULAR TRENDS ; INFECTIONS ; AGENTS ; SUSCEPTIBILITY ; ASPERGILLOSIS ; BUTENAFINE ; RESISTANCE
英文摘要:

The antifungal activity of ZJ-522, a new triazole antifungal agent restructured from fluconazole and butenafine, was compared to that of fluconazole and butenafine against 43 strains of fungi representing 13 fungal species. MICs were determined by using the National Committee for Clinical Laboratory Standards (NCCLS)-recommended broth microdilution method for yeasts, which was modified for filamentous fungi. ZJ-522 was about 50-fold and 2 to 16-fold more potent than fluconazole against yeasts and filamentous fungi respectively, but it was less active than butenafine against filamentous fungi, although butenafine was inactive against most yeasts. Thus, the fashion of ZJ-522 antifungal activity more similar to that of fluconazole than that of butenafine indicates that ZJ-522 should be an inhibitor of lanosterol 14 alpha-demethylase but not of squalene epoxidase, and should be a candidate for clinical development.

语种: 英语
WOS记录号: WOS:000231343500015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51296
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China
2.Second Mil Med Univ, Changhai Hosp, Dept Dermatol, Shanghai 200433, Peoples R China
3.Beijing Univ, Hosp 1, Dept Dermatol, Beijing 100034, Peoples R China

Recommended Citation:
Gao, PH,Cao, YB,Xu, Z,et al. In vitro antifungal activity of ZJ-522, a new triazole restructured from fluconazole and butenatine, against clinically important fungi in comparison with fluconazole and butenatine[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2005,28(8):1414-1417.
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