IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科
学科主题临床医学
In vitro antifungal activity of ZJ-522, a new triazole restructured from fluconazole and butenatine, against clinically important fungi in comparison with fluconazole and butenatine
Gao, PH1; Cao, YB1; Xu, Z1; Zhang, JD1; Zhang, WN1; Wang, Y1; Gu, J1; Cao, YY1; Li, RY1; Jia, XM1; Jiang, YY1
关键词Zj-522 Fluconazole Butenafine Antifungal Activity Mic
刊名BIOLOGICAL & PHARMACEUTICAL BULLETIN
2005-08-01
28期:8页:1414-1417
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]UNITED-STATES ; CANDIDA-ALBICANS ; SECULAR TRENDS ; INFECTIONS ; AGENTS ; SUSCEPTIBILITY ; ASPERGILLOSIS ; BUTENAFINE ; RESISTANCE
英文摘要

The antifungal activity of ZJ-522, a new triazole antifungal agent restructured from fluconazole and butenafine, was compared to that of fluconazole and butenafine against 43 strains of fungi representing 13 fungal species. MICs were determined by using the National Committee for Clinical Laboratory Standards (NCCLS)-recommended broth microdilution method for yeasts, which was modified for filamentous fungi. ZJ-522 was about 50-fold and 2 to 16-fold more potent than fluconazole against yeasts and filamentous fungi respectively, but it was less active than butenafine against filamentous fungi, although butenafine was inactive against most yeasts. Thus, the fashion of ZJ-522 antifungal activity more similar to that of fluconazole than that of butenafine indicates that ZJ-522 should be an inhibitor of lanosterol 14 alpha-demethylase but not of squalene epoxidase, and should be a candidate for clinical development.

语种英语
WOS记录号WOS:000231343500015
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51296
专题北京大学第一临床医学院_皮肤性病科
作者单位1.Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China
2.Second Mil Med Univ, Changhai Hosp, Dept Dermatol, Shanghai 200433, Peoples R China
3.Beijing Univ, Hosp 1, Dept Dermatol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Gao, PH,Cao, YB,Xu, Z,et al. In vitro antifungal activity of ZJ-522, a new triazole restructured from fluconazole and butenatine, against clinically important fungi in comparison with fluconazole and butenatine[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2005,28(8):1414-1417.
APA Gao, PH.,Cao, YB.,Xu, Z.,Zhang, JD.,Zhang, WN.,...&Jiang, YY.(2005).In vitro antifungal activity of ZJ-522, a new triazole restructured from fluconazole and butenatine, against clinically important fungi in comparison with fluconazole and butenatine.BIOLOGICAL & PHARMACEUTICAL BULLETIN,28(8),1414-1417.
MLA Gao, PH,et al."In vitro antifungal activity of ZJ-522, a new triazole restructured from fluconazole and butenatine, against clinically important fungi in comparison with fluconazole and butenatine".BIOLOGICAL & PHARMACEUTICAL BULLETIN 28.8(2005):1414-1417.
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