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Glycogen synthase kinase 3 beta in the nucleus accumbens core is critical for methamphetamine-induced behavioral sensitization
Xu, Chun-mei; Wang, Jun; Wu, Ping; Xue, Yan-xue; Zhu, Wei-li; Li, Qian-qian; Zhai, Hai-feng; Shi, Jie; Lu, Lin
关键词Glycogen Synthase Kinase 3 Beta Locomotor Activity Methamphetamine Nucleus Accumbens Sensitization
刊名JOURNAL OF NEUROCHEMISTRY
2011-07-01
DOI10.1111/j.1471-4159.2011.07281.x
118期:1页:126-139
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]LONG-TERM POTENTIATION ; EXTRACELLULAR DOPAMINE ; VENTRAL STRIATUM ; DIFFERENTIAL CHANGES ; PREFRONTAL CORTEX ; SIGNALING PATHWAY ; COCAINE ADDICTION ; DENDRITIC SPINES ; TRANSGENIC MICE ; RAT-BRAIN
英文摘要

As a ubiquitous serine/threonine protein kinase, glycogen synthase kinase 3 beta (GSK-3 beta) has been considered to be important in the synaptic plasticity that underlies dopamine-related behaviors and diseases. We recently found that GSK-3 beta activity in the nucleus accumbens (NAc) core is critically involved in cocaine-induced behavioral sensitization. The present study further explored the association between the changes in GSK-3 beta activity in the NAc and the chronic administration of methamphetamine. We also examined whether blocking GSK-3 beta activity in the NAc could alter the initiation and expression of methamphetamine (1 mg/kg, i.p.)induced locomotor sensitization in rats using systemic administration of lithium chloride (LiCl, 100 mg/kg, i.p) and brain region-specific administration of the GSK-3 beta inhibitor SB216763 (1 ng/side). We found that GSK-3 beta activity increased in the NAc core, but not NAc shell, after chronic methamphetamine administration. The initiation and expression of methamphetamine-induced locomotor sensitization was attenuated by systemic administration of LiCl and direct infusion of SB216763 into the NAc core, but not NAc shell. These results indicate that GSK-3 beta activity in the NAc core mediates the initiation and expression of methamphetamine-induced locomotor sensitization, suggesting that GSK-3 beta may be a potential target for the treatment of psychostimulant addiction.

语种英语
WOS记录号WOS:000292656600013
项目编号2009CB522000 ; 81071079 ; 7091003 ; 7092058
资助机构National Basic Research Program of China ; Natural Science Foundation of China ; Natural Science Foundation of Beijing Municipality
引用统计
被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51298
专题中国药物依赖性研究所
北京大学医学部管理机构_医学部
作者单位Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Xu, Chun-mei,Wang, Jun,Wu, Ping,et al. Glycogen synthase kinase 3 beta in the nucleus accumbens core is critical for methamphetamine-induced behavioral sensitization[J]. JOURNAL OF NEUROCHEMISTRY,2011,118(1):126-139.
APA Xu, Chun-mei.,Wang, Jun.,Wu, Ping.,Xue, Yan-xue.,Zhu, Wei-li.,...&Lu, Lin.(2011).Glycogen synthase kinase 3 beta in the nucleus accumbens core is critical for methamphetamine-induced behavioral sensitization.JOURNAL OF NEUROCHEMISTRY,118(1),126-139.
MLA Xu, Chun-mei,et al."Glycogen synthase kinase 3 beta in the nucleus accumbens core is critical for methamphetamine-induced behavioral sensitization".JOURNAL OF NEUROCHEMISTRY 118.1(2011):126-139.
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