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学科主题: 药物依赖
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Glycogen synthase kinase 3 beta in the nucleus accumbens core is critical for methamphetamine-induced behavioral sensitization
作者: Xu, Chun-mei; Wang, Jun; Wu, Ping; Xue, Yan-xue; Zhu, Wei-li; Li, Qian-qian; Zhai, Hai-feng; Shi, Jie; Lu, Lin
关键词: glycogen synthase kinase 3 beta ; locomotor activity ; methamphetamine ; nucleus accumbens ; sensitization
刊名: JOURNAL OF NEUROCHEMISTRY
发表日期: 2011-07-01
DOI: 10.1111/j.1471-4159.2011.07281.x
卷: 118, 期:1, 页:126-139
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]: LONG-TERM POTENTIATION ; EXTRACELLULAR DOPAMINE ; VENTRAL STRIATUM ; DIFFERENTIAL CHANGES ; PREFRONTAL CORTEX ; SIGNALING PATHWAY ; COCAINE ADDICTION ; DENDRITIC SPINES ; TRANSGENIC MICE ; RAT-BRAIN
英文摘要:

As a ubiquitous serine/threonine protein kinase, glycogen synthase kinase 3 beta (GSK-3 beta) has been considered to be important in the synaptic plasticity that underlies dopamine-related behaviors and diseases. We recently found that GSK-3 beta activity in the nucleus accumbens (NAc) core is critically involved in cocaine-induced behavioral sensitization. The present study further explored the association between the changes in GSK-3 beta activity in the NAc and the chronic administration of methamphetamine. We also examined whether blocking GSK-3 beta activity in the NAc could alter the initiation and expression of methamphetamine (1 mg/kg, i.p.)induced locomotor sensitization in rats using systemic administration of lithium chloride (LiCl, 100 mg/kg, i.p) and brain region-specific administration of the GSK-3 beta inhibitor SB216763 (1 ng/side). We found that GSK-3 beta activity increased in the NAc core, but not NAc shell, after chronic methamphetamine administration. The initiation and expression of methamphetamine-induced locomotor sensitization was attenuated by systemic administration of LiCl and direct infusion of SB216763 into the NAc core, but not NAc shell. These results indicate that GSK-3 beta activity in the NAc core mediates the initiation and expression of methamphetamine-induced locomotor sensitization, suggesting that GSK-3 beta may be a potential target for the treatment of psychostimulant addiction.

语种: 英语
所属项目编号: 2009CB522000 ; 81071079 ; 7091003 ; 7092058
项目资助者: National Basic Research Program of China ; Natural Science Foundation of China ; Natural Science Foundation of Beijing Municipality
WOS记录号: WOS:000292656600013
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51298
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China

Recommended Citation:
Xu, Chun-mei,Wang, Jun,Wu, Ping,et al. Glycogen synthase kinase 3 beta in the nucleus accumbens core is critical for methamphetamine-induced behavioral sensitization[J]. JOURNAL OF NEUROCHEMISTRY,2011,118(1):126-139.
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