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学科主题: 基础医学
题名:
Drug-repurposing identified the combination of Trolox C and Cytisine for the treatment of type 2 diabetes
作者: Jin, Ling1,2; Tu, Jian2,3; Jia, Jianwei1,2; An, Wenbin3; Tan, Huanran1,2; Cui, Qinghua2,4; Li, Zhixin5
刊名: JOURNAL OF TRANSLATIONAL MEDICINE
发表日期: 2014-05-31
DOI: 10.1186/1479-5876-12-153
卷: 12
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: DISEASE RELATIONSHIPS ; VITAMIN-E ; SIMILARITY ; GENES
英文摘要:

Background: Drug-induced gene expression dataset (for example Connectivity Map, CMap) represent a valuable resource for drug-repurposing, a class of methods for identifying novel indications for approved drugs. Recently, CMap-based methods have successfully applied to identifying drugs for a number of diseases. However, currently few gene expression based methods are available for the repurposing of combined drugs. Increasing evidence has shown that the combination of drugs may valid for novel indications.

Method: Here, for this purpose, we presented a simple CMap-based scoring system to predict novel indications for the combination of two drugs. We then confirmed the effectiveness of the predicted drug combination in an animal model of type 2 diabetes.

Results: We applied the presented scoring system to type 2 diabetes and identified a candidate combination of two drugs, Trolox C and Cytisine. Finally, we confirmed that the predicted combined drugs are effective for the treatment of type 2 diabetes.

Conclusion: The presented scoring system represents one novel method for drug repurposing, which would provide helps for greatly extended the space of drugs.

语种: 英语
所属项目编号: 91339106
项目资助者: Natural Science Foundation of China
WOS记录号: WOS:000338471800002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51303
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Peking Univ, Dept Pharmacol, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Hlth Sci Ctr, Beijing 100191, Peoples R China
3.Beijing Jishuitan Hosp, Dept Electrocardiogram, Beijing 100035, Peoples R China
4.Peking Univ, Dept Biomed Informat, Hlth Sci Ctr, Beijing 100191, Peoples R China
5.Peking Univ, Dept Integrated Chinese & Western Med, Hlth Sci Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Jin, Ling,Tu, Jian,Jia, Jianwei,et al. Drug-repurposing identified the combination of Trolox C and Cytisine for the treatment of type 2 diabetes[J]. JOURNAL OF TRANSLATIONAL MEDICINE,2014,12.
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