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Drug-repurposing identified the combination of Trolox C and Cytisine for the treatment of type 2 diabetes
Jin, Ling1,2; Tu, Jian2,3; Jia, Jianwei1,2; An, Wenbin3; Tan, Huanran1,2; Cui, Qinghua2,4; Li, Zhixin5
刊名JOURNAL OF TRANSLATIONAL MEDICINE
2014-05-31
DOI10.1186/1479-5876-12-153
12
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
资助者Natural Science Foundation of China ; Natural Science Foundation of China
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]DISEASE RELATIONSHIPS ; VITAMIN-E ; SIMILARITY ; GENES
英文摘要

Background: Drug-induced gene expression dataset (for example Connectivity Map, CMap) represent a valuable resource for drug-repurposing, a class of methods for identifying novel indications for approved drugs. Recently, CMap-based methods have successfully applied to identifying drugs for a number of diseases. However, currently few gene expression based methods are available for the repurposing of combined drugs. Increasing evidence has shown that the combination of drugs may valid for novel indications.

Method: Here, for this purpose, we presented a simple CMap-based scoring system to predict novel indications for the combination of two drugs. We then confirmed the effectiveness of the predicted drug combination in an animal model of type 2 diabetes.

Results: We applied the presented scoring system to type 2 diabetes and identified a candidate combination of two drugs, Trolox C and Cytisine. Finally, we confirmed that the predicted combined drugs are effective for the treatment of type 2 diabetes.

Conclusion: The presented scoring system represents one novel method for drug repurposing, which would provide helps for greatly extended the space of drugs.

语种英语
所属项目编号91339106
资助者Natural Science Foundation of China ; Natural Science Foundation of China
WOS记录号WOS:000338471800002
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51303
专题基础医学院_药理学系
作者单位1.Peking Univ, Dept Pharmacol, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Hlth Sci Ctr, Beijing 100191, Peoples R China
3.Beijing Jishuitan Hosp, Dept Electrocardiogram, Beijing 100035, Peoples R China
4.Peking Univ, Dept Biomed Informat, Hlth Sci Ctr, Beijing 100191, Peoples R China
5.Peking Univ, Dept Integrated Chinese & Western Med, Hlth Sci Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Jin, Ling,Tu, Jian,Jia, Jianwei,et al. Drug-repurposing identified the combination of Trolox C and Cytisine for the treatment of type 2 diabetes[J]. JOURNAL OF TRANSLATIONAL MEDICINE,2014,12.
APA Jin, Ling.,Tu, Jian.,Jia, Jianwei.,An, Wenbin.,Tan, Huanran.,...&Li, Zhixin.(2014).Drug-repurposing identified the combination of Trolox C and Cytisine for the treatment of type 2 diabetes.JOURNAL OF TRANSLATIONAL MEDICINE,12.
MLA Jin, Ling,et al."Drug-repurposing identified the combination of Trolox C and Cytisine for the treatment of type 2 diabetes".JOURNAL OF TRANSLATIONAL MEDICINE 12(2014).
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