北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Angiopoietin-1 protects H9c2 cells from H2O2-induced apoptosis through AKT signaling
作者: Wang Zuoyan1; Cui Ming1; Sun Lijie1; Jia Zhuqing1; Bai Yun1; Ma Kangtao1; Chen Fengrong1; Zhou Chunyan1
关键词: angiopoietin-1 ; oxidative stress ; myocyte apoptosis ; AKT
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2007-08-03
DOI: 10.1016/j.bbrc.2007.05.172
卷: 359, 期:3, 页:685-690
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: PATHWAY ; DEATH
英文摘要:

Loss of cardiomyocytes by apoptosis is proposed to cause ventricular remodeling and heart failure. Reactive oxygen species-induced apoptosis of cardiomyocytes has been reported to play an important role in many types of pathological processes of the heart. We investigated whether angiopoietin-1 (Ang1) has direct cytoprotective effects on cardiomyocytes against oxidative stress.

Cultured H9c2 cells (cardiomyocytes) were treated with hydrogen peroxide (H2O2). Apoptosis was evaluated by flow cytometry, TUNEL assay and DNA laddering. The H2O2 treatment caused typical apoptosis of H9c2 cells in a time-dependent manner. Transfection of recombinant adenovirus expressing Ang1 resulted in a sustained phosphorylation of AKT and inhibition Of H2O2-induced apoptosis in H9c2 cells. This effect could be reversed by AKT inhibition.

These results suggest that Ang1 protects cardiomyocytes from oxidative stress-induced apoptosis by regulating the activity of AKT, (c) 2007 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000247582500047
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51312
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ Third Hosp, Dept Cardiol, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Sch Basic Med Sci, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Sch Basic Med Sci, Beijing 100083, Peoples R China

Recommended Citation:
Wang Zuoyan,Cui Ming,Sun Lijie,et al. Angiopoietin-1 protects H9c2 cells from H2O2-induced apoptosis through AKT signaling[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2007,359(3):685-690.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang Zuoyan]'s Articles
[Cui Ming]'s Articles
[Sun Lijie]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang Zuoyan]‘s Articles
[Cui Ming]‘s Articles
[Sun Lijie]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace