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学科主题: 临床医学
题名:
A study on small-world brain functional networks altered by postherpetic neuralgia
作者: Zhang, Yue1; Liu, Jing2; Li, Longchuan3,4; Du, Minyi5; Fang, Wenxue5; Wang, Dongxin5; Jiang, Xuexiang2; Hu, Xiaoping4; Zhang, Jue1; Wang, Xiaoying2; Fang, Jing1
关键词: Small-world ; Brain functional networks ; Resting-state fMRI ; Chronic pain ; Postherpetic neuralgia
刊名: MAGNETIC RESONANCE IMAGING
发表日期: 2014-05-01
DOI: 10.1016/j.mri.2013.12.016
卷: 32, 期:4, 页:359-365
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: AFFECTIVE DIMENSION ; CHRONIC PAIN ; PERCEPTION ; MODULATION ; MECHANISMS ; DYNAMICS
英文摘要:

Understanding the effect of postherpetic neuralgia (PHN) pain on brain activity is important for clinical strategies. This is the first study, to our knowledge, to relate PHN pain to small-world properties of brain functional networks. Functional magnetic resonance imaging (fMRI) was used to construct functional brain networks of the subjects during the resting state. Sixteen patients with PHN pain and 16 (8 males, 8 females for both groups) age-matched controls were studied. The PHN patients exhibited decreased local efficiency along with non-significant changes of global efficiency in comparison with the healthy controls. Moreover, regional nodal efficiency was found to be significantly affected by PHN pain in the areas related to sense (postcentral gyrus, inferior parietal gyrus and thalamus), memory/affective processes (parahippocampal gyms) and emotional activities (putamen). Significant correlation (p <0.05) was also found between the nodal efficiency of putamen and pain intensity in PHN patients. Our results suggest that PHN modulates the local efficiency, and the small-world properties of brain networks may have potentials to objectively evaluate pain information in clinic. (C) 2014 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000333868200008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51314
Appears in Collections:北京大学第一临床医学院_放射治疗科_期刊论文

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作者单位: 1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
2.Emory Univ, Sch Med, Marcus Autism Ctr, Atlanta, GA USA
3.Peking Univ, Hosp 1, Dept Radiol, Beijing 100871, Peoples R China
4.Emory Univ, Georgia Inst Technol, Biomed Imaging Technol Ctr, Dept Biomed Engn, Atlanta, GA USA
5.Peking Univ, Hosp 1, Dept Anesthesiol, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Yue,Liu, Jing,Li, Longchuan,et al. A study on small-world brain functional networks altered by postherpetic neuralgia[J]. MAGNETIC RESONANCE IMAGING,2014,32(4):359-365.
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