北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Association between serum uric acid and different states of glucose metabolism and glomerular filtration rate
作者: Cai Xiao-ling; Han Xue-yao; Ji Li-nong
关键词: serum uric acid ; Modification of Diet in Renal Disease ; impaired glucose regulation ; diabetes mellitus
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2010-11-05
DOI: 10.3760/cma.j.issn.0366-6999.2010.21.030
卷: 123, 期:21, 页:3118-3122
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: POPULATION ; HYPERURICEMIA ; HYPERTENSION ; INSULIN ; MEN ; ATHEROSCLEROSIS ; PREVALENCE ; DISEASE ; SODIUM ; LEVEL
英文摘要:

Background Recently, it has been suggested that the serum uric acid (SUA) level decreased in diabetic patients. The aim of this study was to explore the association between SUA level and different state of glucose metabolism and glomerular filtration rate (GFR) reflected by the simplified Modification of Diet in Renal Disease (MDRD) equation and to test the hypothesis that high MDRD is one of the determinants of SUA level.

Methods This cross-sectional study included 2373 subjects in Beijing who underwent a 75 g oral glucose tolerance test (OGTT) for screening of diabetes. According to the states of glucose metabolism, they were divided into normal glucose tolerance, impaired glucose regulation and diabetes.

Results Multiple stepwise linear regression analysis showed that adjusted by gender, SUA was positively correlated with body mass index (BMI), waist/hippo ratio, systolic blood pressure (SBP) and triglyceride, meanwhile negatively correlated with age, hemoglobin A1c, fasting insulin and MDRD. There was an increasing trend in SUA concentration and a decreasing trend in MDRD when the levels of fasting plasma glucose (FPG) increased from low to high up to the FPG level of 8.0 mmol/L; thereafter, the SUA concentration started to decrease with further increases in FPG levels, and the MDRD started to increase with further increases in FPG levels.

Conclusion This study confirmed the previous finding that SUA decreased in diabetes and provided the evidence that the increased MDRD might contribute to the fall of SUA. Chin Med J 2010;123(21):3118-3122

语种: 英语
WOS记录号: WOS:000284387200030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51315
Appears in Collections:北京大学第二临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100044, Peoples R China

Recommended Citation:
Cai Xiao-ling,Han Xue-yao,Ji Li-nong. Association between serum uric acid and different states of glucose metabolism and glomerular filtration rate[J]. CHINESE MEDICAL JOURNAL,2010,123(21):3118-3122.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Cai Xiao-ling]'s Articles
[Han Xue-yao]'s Articles
[Ji Li-nong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Cai Xiao-ling]‘s Articles
[Han Xue-yao]‘s Articles
[Ji Li-nong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace