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学科主题临床医学
Gender and Age Interact to Affect Early Outcome after Intracerebral Hemorrhage
Umeano, Odera1; Phillips-Bute, Barbara2; Hailey, Claire E.3; Sun, Wei4; Gray, Marisa C.3; Roulhac-Wilson, Briana5; McDonagh, David L.2; Kranz, Peter G.6; Laskowitz, Daniel T.7; James, Michael L.7
刊名PLOS ONE
2013-11-27
DOI10.1371/journal.pone.0081664
8期:11
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]TRAUMATIC BRAIN-INJURY ; STROKE SUBTYPES ; SEX-DIFFERENCES ; CLINICAL-TRIAL ; ESTROGEN ; POPULATION ; MORTALITY ; SCALE ; PROGESTERONE ; ASSOCIATION
英文摘要

Background: Intracerebral hemorrhage (ICH) is a common and devastating form of cerebrovascular disease. In ICH, gender differences in outcomes remain relatively understudied but have been examined in other neurological emergencies. Further, a potential effect of age and gender on outcomes after ICH has not been explored. This study was designed to test the hypothesis that age and gender interact to modify neurological outcomes after ICH.

Methods: Adult patients admitted with spontaneous primary supratentorial ICH from July 2007 through April 2010 were assessed via retrospective analysis of an existing stroke database at Duke University. Univariate analysis of collected variables was used to compare gender and outcome. Unfavorable outcome was defined as discharge to hospice or death. Using multivariate regression, the combined effect of age and gender on outcome after ICH was analyzed.

Results: In this study population, women were younger (61.1 +/- 14.5 versus 65.8 +/- 17.3 years, p=0.03) and more likely to have a history of substance abuse (35% versus 8.9%, p<0.0001) compared to men. Multivariable models demonstrated that advancing age had a greater effect on predicting discharge outcome in women compared to men (p=0.02). For younger patients, female sex was protective; however, at ages greater than 60 years, female sex was a risk factor for discharge to hospice or death.

Conclusion: While independently associated with discharge to hospice or death after ICH, the interaction effect between gender and age demonstrated significantly stronger correlation with early outcome after ICH in a single center cohort. Prospective study is required to verify these findings.

语种英语
WOS记录号WOS:000327652100092
资助机构American Heart Association - Scientist Development Grant
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51317
专题北京大学第一临床医学院_神经内科
作者单位1.Duke Univ, Sch Med, Durham, NC USA
2.Duke Univ, Dept Anesthesiol, Durham, NC USA
3.Duke Univ, Durham, NC USA
4.Duke Univ, Dept Radiol, Durham, NC 27710 USA
5.Univ N Carolina, Sch Med, Chapel Hill, NC USA
6.Peking Univ, Hosp 1, Dept Neurol, Beijing 100871, Peoples R China
7.Duke Univ, Brain Injury Translat Res Ctr, Dept Neurol, Durham, NC 27710 USA
推荐引用方式
GB/T 7714
Umeano, Odera,Phillips-Bute, Barbara,Hailey, Claire E.,et al. Gender and Age Interact to Affect Early Outcome after Intracerebral Hemorrhage[J]. PLOS ONE,2013,8(11).
APA Umeano, Odera.,Phillips-Bute, Barbara.,Hailey, Claire E..,Sun, Wei.,Gray, Marisa C..,...&James, Michael L..(2013).Gender and Age Interact to Affect Early Outcome after Intracerebral Hemorrhage.PLOS ONE,8(11).
MLA Umeano, Odera,et al."Gender and Age Interact to Affect Early Outcome after Intracerebral Hemorrhage".PLOS ONE 8.11(2013).
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