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学科主题: 公共卫生
题名:
Interactions of renin-angiotensin system gene polymorphisms and antihypertensive effect of benazepril in Chinese population
作者: Chen, Qing1,2; Yu, Can-Qing1,2; Tang, Xun1,2; Chen, Da-Fang1,2; Tian, Jun1,2; Cao, Yang1,2; Fan, Wen-Yi1,2; Cao, Wei-Hua1,2; Zhan, Si-Yan1,2; Lv, Jun1,2; Guo, Xiao-Xia1,2; Hu, Yong-Hua1,2; Lee, Li-Ming1,2
关键词: angiotensin-converting enzyme inhibitors ; epistasis ; generalized multifactor dimensionality reduction ; hypertension ; pharmacogenetics ; renin-angiotensin system
刊名: PHARMACOGENOMICS
发表日期: 2011-05-01
DOI: 10.2217/PGS.11.2
卷: 12, 期:5, 页:735-743
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: SINGLE-NUCLEOTIDE POLYMORPHISMS ; CONVERTING ENZYME-INHIBITOR ; CORONARY-ARTERY-DISEASE ; BLOOD-PRESSURE RESPONSE ; ESSENTIAL-HYPERTENSION ; RECEPTOR GENE ; TREATMENT BENEFIT ; ACE-INHIBITORS ; II RECEPTORS ; ANG-II
英文摘要:

Aim: Angiotensin-converting enzyme inhibitors are widely used antihypertensive drugs with individual response variation. We studied whether interactions of AGT, AGTR1 and ACE2 gene polymorphisms affect this response. Materials & methods: Our study is based on a 3-year field trial with 1831 hypertensive patients prescribed benazepril. Generalized multifactor dimensionality reduction was used to explore interaction models and logistic regressions were used to confirm them. Results: A two-locus model involving the AGT and ACE2 genes was found in males, the sensitive genotypes showed an odds ratio (OR) of 1.9 (95% CI: 1.3-2.8) when compared with nonsensitive genotypes. Two AGT-AGTR1 models were found in females, with an OR of 3.5 (95% CI: 2.0-5.9) and 3.1 (95% CI: 1.8-5.3). Conclusion: Gender-specific gene-gene interactions of the AGT, AGTR1 and ACE2 genes were associated with individual variation of response to benazepril. Further studies are needed to confirm this finding.

语种: 英语
所属项目编号: 96-906-02-05 ; 2001BAF03B02 ; 2006BAI01A03-[16] ; 30671807 ; 30872173
项目资助者: National Key Technologies R&amp ; D Program of China ; Mega-projects of Science Research ; National Natural Sciences Foundation of China
WOS记录号: WOS:000292128900020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51319
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Minist Educ, Key Lab Epidemiol, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China

Recommended Citation:
Chen, Qing,Yu, Can-Qing,Tang, Xun,et al. Interactions of renin-angiotensin system gene polymorphisms and antihypertensive effect of benazepril in Chinese population[J]. PHARMACOGENOMICS,2011,12(5):735-743.
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