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Interactions of renin-angiotensin system gene polymorphisms and antihypertensive effect of benazepril in Chinese population
Chen, Qing1,2; Yu, Can-Qing1,2; Tang, Xun1,2; Chen, Da-Fang1,2; Tian, Jun1,2; Cao, Yang1,2; Fan, Wen-Yi1,2; Cao, Wei-Hua1,2; Zhan, Si-Yan1,2; Lv, Jun1,2; Guo, Xiao-Xia1,2; Hu, Yong-Hua1,2; Lee, Li-Ming1,2
关键词Angiotensin-converting Enzyme Inhibitors Epistasis Generalized Multifactor Dimensionality Reduction Hypertension Pharmacogenetics Renin-angiotensin System
刊名PHARMACOGENOMICS
2011-05-01
DOI10.2217/PGS.11.2
12期:5页:735-743
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]SINGLE-NUCLEOTIDE POLYMORPHISMS ; CONVERTING ENZYME-INHIBITOR ; CORONARY-ARTERY-DISEASE ; BLOOD-PRESSURE RESPONSE ; ESSENTIAL-HYPERTENSION ; RECEPTOR GENE ; TREATMENT BENEFIT ; ACE-INHIBITORS ; II RECEPTORS ; ANG-II
英文摘要

Aim: Angiotensin-converting enzyme inhibitors are widely used antihypertensive drugs with individual response variation. We studied whether interactions of AGT, AGTR1 and ACE2 gene polymorphisms affect this response. Materials & methods: Our study is based on a 3-year field trial with 1831 hypertensive patients prescribed benazepril. Generalized multifactor dimensionality reduction was used to explore interaction models and logistic regressions were used to confirm them. Results: A two-locus model involving the AGT and ACE2 genes was found in males, the sensitive genotypes showed an odds ratio (OR) of 1.9 (95% CI: 1.3-2.8) when compared with nonsensitive genotypes. Two AGT-AGTR1 models were found in females, with an OR of 3.5 (95% CI: 2.0-5.9) and 3.1 (95% CI: 1.8-5.3). Conclusion: Gender-specific gene-gene interactions of the AGT, AGTR1 and ACE2 genes were associated with individual variation of response to benazepril. Further studies are needed to confirm this finding.

语种英语
WOS记录号WOS:000292128900020
项目编号96-906-02-05 ; 2001BAF03B02 ; 2006BAI01A03-[16] ; 30671807 ; 30872173
资助机构National Key Technologies R&amp ; D Program of China ; Mega-projects of Science Research ; National Natural Sciences Foundation of China
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51319
专题北京大学公共卫生学院
北京大学医学部管理机构_科学研究处
北京大学医学部管理机构_医学部
北京大学基础医学院
北京大学公共卫生学院_流行病与卫生统计学系
北京大学第一临床医学院_医院管理办公室
北京大学临床肿瘤学院_麻醉科
作者单位1.Minist Educ, Key Lab Epidemiol, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
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GB/T 7714
Chen, Qing,Yu, Can-Qing,Tang, Xun,et al. Interactions of renin-angiotensin system gene polymorphisms and antihypertensive effect of benazepril in Chinese population[J]. PHARMACOGENOMICS,2011,12(5):735-743.
APA Chen, Qing.,Yu, Can-Qing.,Tang, Xun.,Chen, Da-Fang.,Tian, Jun.,...&Lee, Li-Ming.(2011).Interactions of renin-angiotensin system gene polymorphisms and antihypertensive effect of benazepril in Chinese population.PHARMACOGENOMICS,12(5),735-743.
MLA Chen, Qing,et al."Interactions of renin-angiotensin system gene polymorphisms and antihypertensive effect of benazepril in Chinese population".PHARMACOGENOMICS 12.5(2011):735-743.
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