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学科主题: 临床医学
题名:
Distribution of HPV genotypes in uterine cervical lesions in Yanbian, northern China
作者: Zhao, Yiwei1; Lin, Hai4; Shen, Danhua3; Xuan, Yanhua1; Lin, Zhenhua1,2,5
关键词: cervix uteri ; genotyping ; HPV
刊名: PATHOLOGY INTERNATIONAL
发表日期: 2008-10-01
DOI: 10.1111/j.1440-1827.2008.02283.x
卷: 58, 期:10, 页:643-647
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: HUMAN-PAPILLOMAVIRUS INFECTION ; REPUBLIC-OF-CHINA ; INTRAEPITHELIAL NEOPLASIA ; P16(INK4A) EXPRESSION ; POPULATION ; WOMEN ; TYPE-16 ; CANCER ; RISK ; PREVALENCE
英文摘要:

The aim of the present study was to investigate the distribution of HPV genotypes in uterine cervical lesions in Yanbian, northern China. HPV-DNA chip (oligonucleotide microarray) and cervical biopsy were used for 322 women in 1998-2005. All the normal cervical epithelia were negative for HPV. The positive rate of high-risk HPV was 33.9% in cervical intra-epithelial neoplasia (CIN)-1, 51.6% in CIN-2, 57.7% in CIN-3, 66.7% in cervical glandular intra-epithelial neoplasia (CGIN), 91.7% in squamous cell carcinoma (SCC), and 78.6% in adenocarcinoma. HPV-16 was the major type in all CIN and SCC cervical lesions, but in cervical adenocarcinoma HPV-18 was the most common type, and HPV-16 was the second most common type. Several cases of CIN-3, SCC and adenocarcinoma had multiple types of HPV, but there was none in CIN-1/2. In summary, HPV-16 is the type most frequently involved in the development of SCC of the cervix, and this may be helpful for the prediction of the development and progress of CIN-2/3, whereas both HPV-18 and -16 play a prominent role in the development of adenocarcinoma and CGIN of the cervix in Yanbian, northern China.

语种: 英语
所属项目编号: NCET-07-0734 ; 30560047 ; 20050115 ; 20060103 ; 2005-383
项目资助者: Program of New Century Talents in University ; National Natural Science Foundation of China ; Excellent Youth Scientific Study Fund of Jilin Province ; Ministry of Education, China
WOS记录号: WOS:000259219400005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51325
Appears in Collections:北京大学第二临床医学院_病理科_期刊论文

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作者单位: 1.Johns Hopkins Univ, Inst Med, Dept Pathol, Baltimore, MD USA
2.Yanbian Univ, Coll Med, Dept Pathol, Yanji 133000, Peoples R China
3.Yanbian Univ, Minist Educ, Key Lab Nat Resources Changbai Mt & Funct Mol, Yanji 133000, Peoples R China
4.Beijing Univ, Renmin Hosp, Dept Pathol, Beijing 100871, Peoples R China
5.Univ Maryland, Sch Med, Dept Med, Div Nephrol, Baltimore, MD 21201 USA

Recommended Citation:
Zhao, Yiwei,Lin, Hai,Shen, Danhua,et al. Distribution of HPV genotypes in uterine cervical lesions in Yanbian, northern China[J]. PATHOLOGY INTERNATIONAL,2008,58(10):643-647.
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