IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
LOVASTATIN IMPROVES NEUROLOGICAL OUTCOME AFTER NUCLEUS BASALIS MAGNOCELLULARIS LESION IN RATS
Zhao, Z.2; Zhao, S.3; Xu, N.4; Yu, C.1; Guan, S.5; Liu, X.4; Huang, L.1; Liao, W.1; Jia, W.3,6
关键词Lovastatin Morris Water Maze Nucleus Basalis Magnocellularis Neuroprotection Muscarinic/nmda Receptor Signaling Pathway
刊名NEUROSCIENCE
2010-05-19
DOI10.1016/j.neuroscience.2010.02.054
167期:3页:954-963
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
资助者Chinese Medical Association ; National Health Ministry ; Chinese Medical Association ; National Health Ministry
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]TRAUMATIC BRAIN-INJURY ; ALZHEIMERS-DISEASE ; ENDOTHELIAL-CELLS ; KINASE PATHWAY ; UP-REGULATION ; CHOLINE-ACETYLTRANSFERASE ; SYNAPTIC PLASTICITY ; SIGNALING PATHWAYS ; RECEPTOR-BINDING ; SPATIAL MEMORY
英文摘要

Increasing evidence indicates that statins, specific inhibitors of 3-hydroxy-3-methylglutaryl (HMG)-coenzyme A (CoA) reductase, exerts neuroprotective actions rather than simply lowering cholesterol. However, the underlying mechanism has not been elucidated clearly. Here, the effect of lovastatin on the neurological outcomes of nucleus basalis magnocellularis (NBM)-lesioned rats and the pathophysiological mechanisms were investigated. Sprague-Dawley rats were divided into three groups: (i) a sham group; (ii) a model group: bilateral NBM of rats were injured by infusion of ibotenic acid; and (iii) a lovastatin-treated group: lovastatin was administrated orally for 4 weeks before treated by ibotenic acid. We show that lovastatin significantly improves the neurological outcomes as well as the choline acetyltransferase (ChAT) activity and muscarinic/NMDA receptor binding activity impaired by NBM lesion, and that lovastatin prevents neuron loss and induces Akt whereas inhibits p38 phosphorylation. Overall, the neuro-restorative and -protective effect of lovastatin may be attributed to the regulation of Akt- and p38-mediated signaling pathway together with improvement of muscarinic/NMDA receptor functions. Statins may be useful in the treatment of neurological disorders. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.

语种英语
所属项目编号09010580213
资助者Chinese Medical Association ; National Health Ministry ; Chinese Medical Association ; National Health Ministry
WOS记录号WOS:000276985800039
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51326
专题北京大学第三临床医学院
作者单位1.China Japan Friendship Hosp, Natl Integrat Med Ctr Cardiovasc Dis, Beijing, Peoples R China
2.Hebei Med Univ, Coll Tradit Chinese Med, Shijiazhuang, Peoples R China
3.PepMetr & Pegasus Pharmaceut Grp Inc, Unit 110 116, Richmond, BC V6X 1Z7, Canada
4.Peking Univ, Dept Rheumatol & Immunol, Hosp 3, Beijing 100029, Peoples R China
5.Hebei Med Univ, Dept Pharmacol, Shijiazhuang, Peoples R China
6.Univ British Columbia, Dept Surg, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
推荐引用方式
GB/T 7714
Zhao, Z.,Zhao, S.,Xu, N.,et al. LOVASTATIN IMPROVES NEUROLOGICAL OUTCOME AFTER NUCLEUS BASALIS MAGNOCELLULARIS LESION IN RATS[J]. NEUROSCIENCE,2010,167(3):954-963.
APA Zhao, Z..,Zhao, S..,Xu, N..,Yu, C..,Guan, S..,...&Jia, W..(2010).LOVASTATIN IMPROVES NEUROLOGICAL OUTCOME AFTER NUCLEUS BASALIS MAGNOCELLULARIS LESION IN RATS.NEUROSCIENCE,167(3),954-963.
MLA Zhao, Z.,et al."LOVASTATIN IMPROVES NEUROLOGICAL OUTCOME AFTER NUCLEUS BASALIS MAGNOCELLULARIS LESION IN RATS".NEUROSCIENCE 167.3(2010):954-963.
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