学科主题基础医学
Long-Term Stimulation with Electroacupuncture at DU20 and ST36 Rescues Hippocampal Neuron through Attenuating Cerebral Blood Flow in Spontaneously Hypertensive Rats
Tian, Gui-Hua1,2,3; Sun, Kai3,4; Huang, Ping3,4; Zhou, Chang-Man3,5; Yao, Hai-Jiang1; Huo, Ze-Jun1; Hao, Hui-Feng3,4,6; Yang, Lei5; Pan, Chun-Shui3,4; He, Ke3,4,6; Fan, Jing-Yu3,4; Li, Zhi-Gang1; Han, Jing-Yan3,4,6
刊名EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
2013
DOI10.1155/2013/482947
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Integrative & Complementary Medicine
资助者Tianjin Tasly Group, Tianjin, China ; Tianjin Tasly Group, Tianjin, China
研究领域[WOS]Integrative & Complementary Medicine
关键词[WOS]COGNITIVE FUNCTION ; ISCHEMIA-REPERFUSION ; ANGIOTENSIN-II ; BRAIN ; PRESSURE ; MICROCIRCULATION ; MECHANISMS ; DISEASE ; TARGET ; DAMAGE
英文摘要

This study was designed to investigate the effect of long-term electroacupuncture at Baihui (DU20) and Zusanli (ST36) on cerebral microvessels and neurons in CA1 region of hippocampus in spontaneously hypertensive rats (SHR). A total of 45 male Wistar rats and 45 SHR were randomly grouped, with or without electroacupuncture (EA) at DU20 and ST36, once every other day for a period of 8 weeks. The mean arterial pressure (MAP) was measured once every 2 weeks. Cerebral blood flow (CBF) and the number of open microvessels in hippocampal CA1 region were detected by Laser Doppler and immunohistochemistry, respectively. Nissl staining and Western blotting were performed, respectively, to determine hippocampus morphology and proteins that were implicated in the concerning signaling pathways. The results showed that the MAP in SHR increased linearly over the observation period and was significantly reduced following electroacupuncture as compared with sham control SHR rats, while no difference was observed in Wistar rats between EA and sham control. The CBF, learning and memory capacity, and capillary rarefaction of SHR were improved by EA. The upregulation of angiotensin II type I receptor (AT1R), endothelin receptor (ETAR), and endothelin-1 (ET-1) in SHR rats was attenuated by electroacupuncture, suggesting an implication of AT1R, ETAR, and ET-1 pathway in the effect of EA.

语种英语
所属项目编号20050230
资助者Tianjin Tasly Group, Tianjin, China ; Tianjin Tasly Group, Tianjin, China
WOS记录号WOS:000317514100001
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51327
专题北京大学基础医学院_北大医学部天士力微循环研究中心
作者单位1.Beijing Univ Chinese Med, Sch Acupuncture & Moxibust, Beijing 100029, Peoples R China
2.Beijing Univ Chinese Med, Dongzhimen Hosp, Beijing 101121, Peoples R China
3.Peking Univ, Tasly Microcirculat Res Ctr, Hlth Sci Ctr, Beijing 100191, Peoples R China
4.State Adm Tradit Chinese Med Peoples Republ China, Key Lab Microcirculat, Beijing 100191, Peoples R China
5.Peking Univ, Sch Basic Med Sci, Dept Anat, Beijing 100191, Peoples R China
6.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Tian, Gui-Hua,Sun, Kai,Huang, Ping,et al. Long-Term Stimulation with Electroacupuncture at DU20 and ST36 Rescues Hippocampal Neuron through Attenuating Cerebral Blood Flow in Spontaneously Hypertensive Rats[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013.
APA Tian, Gui-Hua.,Sun, Kai.,Huang, Ping.,Zhou, Chang-Man.,Yao, Hai-Jiang.,...&Han, Jing-Yan.(2013).Long-Term Stimulation with Electroacupuncture at DU20 and ST36 Rescues Hippocampal Neuron through Attenuating Cerebral Blood Flow in Spontaneously Hypertensive Rats.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA Tian, Gui-Hua,et al."Long-Term Stimulation with Electroacupuncture at DU20 and ST36 Rescues Hippocampal Neuron through Attenuating Cerebral Blood Flow in Spontaneously Hypertensive Rats".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013).
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