|Mechanism of emergency contraception with gestrinone: a preliminary investigation|
|Gao, Xuefeng1; Wu, Erruo1; Chen, Guian1|
|关键词||Emergency Contraception Gestrinone Estrogen Progesterone Receptor Integrins|
|WOS标题词||Science & Technology|
|类目[WOS]||Obstetrics & Gynecology|
|研究领域[WOS]||Obstetrics & Gynecology|
|关键词[WOS]||ENDOMETRIOSIS ; R-2323 ; INTEGRINS ; TRIAL|
Background: A previous investigation showed that among 120 healthy women treated with a single oral dose of gestrinone for emergency contraception (EC), there was only one pregnancy. The effect of a single oral dose of gestrinone given for EC on ovarian function and endometrial development was studied.
Study Design: Healthy fertile women were randomly assigned to Group A (n=8) or Group B (n=7). Gestrinone 5 mg was orally administered to each woman before (Group A) or after (Group 13) ovulation. The day of ovulation was determined by transvaginal ultrasound and by urinary luteinizing hormone (LH) measured by enzyme immunoassay (One Step LH Ovulation Test). An endometrial biopsy was performed during implantation. Endometrial maturation and expression of markers of endometrial receptivity were analyzed. The tested markers were integrins alpha(1)beta(1), alpha(4)beta(1) and beta(3) Serum estradiol (E-2) and progesterone (P) levels in serum were determined by radioimmunoassay, and estradiol receptors and progesterone receptors (PRs) in the endometrium were assessed by immunohistochemistry.
Results: Gestrinone administered during the periovulatory period did not affect follicular development, ovulation, menstrual cycle length and E-2 and P levels but decreased the expression of PR in the endometrium. Integrin alpha(4)beta(1) tended to increase after treatment with gestrinone without reaching statistical significance.
Conclusion: The mode of action of gestritione used for EC is probably inhibition of implantation by acting on the endometrium rather than inhibition of ovulation. (c) 2007 Published by Elsevier Inc.
|作者单位||1.Natl Res Inst Family Planning, Beijing 100081, Peoples R China|
2.Peking Univ, Dept Obstet & Gynecol, Hosp 3, Beijing 100083, Peoples R China
|Gao, Xuefeng,Wu, Erruo,Chen, Guian. Mechanism of emergency contraception with gestrinone: a preliminary investigation[J]. CONTRACEPTION,2007,76(3):221-227.|
|APA||Gao, Xuefeng,Wu, Erruo,&Chen, Guian.(2007).Mechanism of emergency contraception with gestrinone: a preliminary investigation.CONTRACEPTION,76(3),221-227.|
|MLA||Gao, Xuefeng,et al."Mechanism of emergency contraception with gestrinone: a preliminary investigation".CONTRACEPTION 76.3(2007):221-227.|