IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Mechanism of emergency contraception with gestrinone: a preliminary investigation
Gao, Xuefeng1; Wu, Erruo1; Chen, Guian1
关键词Emergency Contraception Gestrinone Estrogen Progesterone Receptor Integrins
刊名CONTRACEPTION
2007-09-01
DOI10.1016/j.contraception.2007.05.089
76期:3页:221-227
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology
研究领域[WOS]Obstetrics & Gynecology
关键词[WOS]ENDOMETRIOSIS ; R-2323 ; INTEGRINS ; TRIAL
英文摘要

Background: A previous investigation showed that among 120 healthy women treated with a single oral dose of gestrinone for emergency contraception (EC), there was only one pregnancy. The effect of a single oral dose of gestrinone given for EC on ovarian function and endometrial development was studied.

Study Design: Healthy fertile women were randomly assigned to Group A (n=8) or Group B (n=7). Gestrinone 5 mg was orally administered to each woman before (Group A) or after (Group 13) ovulation. The day of ovulation was determined by transvaginal ultrasound and by urinary luteinizing hormone (LH) measured by enzyme immunoassay (One Step LH Ovulation Test). An endometrial biopsy was performed during implantation. Endometrial maturation and expression of markers of endometrial receptivity were analyzed. The tested markers were integrins alpha(1)beta(1), alpha(4)beta(1) and beta(3) Serum estradiol (E-2) and progesterone (P) levels in serum were determined by radioimmunoassay, and estradiol receptors and progesterone receptors (PRs) in the endometrium were assessed by immunohistochemistry.

Results: Gestrinone administered during the periovulatory period did not affect follicular development, ovulation, menstrual cycle length and E-2 and P levels but decreased the expression of PR in the endometrium. Integrin alpha(4)beta(1) tended to increase after treatment with gestrinone without reaching statistical significance.

Conclusion: The mode of action of gestritione used for EC is probably inhibition of implantation by acting on the endometrium rather than inhibition of ovulation. (c) 2007 Published by Elsevier Inc.

语种英语
WOS记录号WOS:000249256800008
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51328
专题北京大学第三临床医学院
作者单位1.Natl Res Inst Family Planning, Beijing 100081, Peoples R China
2.Peking Univ, Dept Obstet & Gynecol, Hosp 3, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Gao, Xuefeng,Wu, Erruo,Chen, Guian. Mechanism of emergency contraception with gestrinone: a preliminary investigation[J]. CONTRACEPTION,2007,76(3):221-227.
APA Gao, Xuefeng,Wu, Erruo,&Chen, Guian.(2007).Mechanism of emergency contraception with gestrinone: a preliminary investigation.CONTRACEPTION,76(3),221-227.
MLA Gao, Xuefeng,et al."Mechanism of emergency contraception with gestrinone: a preliminary investigation".CONTRACEPTION 76.3(2007):221-227.
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