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学科主题口腔医学
Use of Poly (Amidoamine) Dendrimer for Dentinal Tubule Occlusion: A Preliminary Study
Wang, Tianda1; Yang, Sheng1,2; Wang, Lei1; Feng, Hailan1
刊名PLOS ONE
2015-04-17
DOI10.1371/journal.pone.0124735
10期:4
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]CALCIUM-PHOSPHATE PRECIPITATION ; DEMINERALIZED HUMAN DENTIN ; SELF-ASSEMBLED MONOLAYERS ; IN-VITRO ; PAMAM DENDRIMERS ; AMMONIUM HEXAFLUOROSILICATE ; DESENSITIZING AGENTS ; CARBONATED APATITE ; HYPERSENSITIVITY ; HYDROXYAPATITE
英文摘要

The occlusion of dentinal tubules is an effective method to alleviate the symptoms caused by dentin hypersensitivity, a significant health problem in dentistry and daily life. The in situ mineralization within dentinal tubules is a promising treatment for dentin hypersensitivity as it induces the formation of mineral on the sensitive regions and occludes the dentinal tubules. This study was carried out to evaluate the in vitro effect of a whole generation poly (amidoamine) (PAMAM) dendrimer (G3.0) on dentinal tubule occlusion by inducing mineralization within dentinal tubules. Dentin discs were treated with PAMAM dendrimers using two methods, followed by the in vitro characterization using Attenuated total reflection Fourier-transform infrared spectroscopy (ATR-FTIR), X-ray diffraction (XRD), Field emission scanning electron microscopy (FE-SEM) and Energy-Dispersive X-ray Spectroscopy (EDS). These results showed that G3.0 PAMAM dendrimers coated on dentin surface and infiltrated in dentinal tubules could induce hydroxyapatite formation and resulted in effective dentinal tubule occlusion. Moreover, crosslinked PAMAM dendrimers could induce the remineralization of demineralized dentin and thus had the potential in dentinal tubule occlusion. In this in vitro study, dentinal tubules occlusion could be achieved by using PAMAM dendrimers. This could lead to the development of a new therapeutic technique for the treatment of dentin hypersensitivity.

语种英语
WOS记录号WOS:000353017000143
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51331
专题北京大学口腔医学院_口腔修复科
作者单位1.Peking Univ, Dept Prosthodont, Sch & Hosp Stomatol, Beijing 100871, Peoples R China
2.Chongqing Med Univ, Coll Stomatol, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China
推荐引用方式
GB/T 7714
Wang, Tianda,Yang, Sheng,Wang, Lei,et al. Use of Poly (Amidoamine) Dendrimer for Dentinal Tubule Occlusion: A Preliminary Study[J]. PLOS ONE,2015,10(4).
APA Wang, Tianda,Yang, Sheng,Wang, Lei,&Feng, Hailan.(2015).Use of Poly (Amidoamine) Dendrimer for Dentinal Tubule Occlusion: A Preliminary Study.PLOS ONE,10(4).
MLA Wang, Tianda,et al."Use of Poly (Amidoamine) Dendrimer for Dentinal Tubule Occlusion: A Preliminary Study".PLOS ONE 10.4(2015).
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