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IL-37 Alleviates Rheumatoid Arthritis by Suppressing IL-17 and IL-17-Triggering Cytokine Production and Limiting Th17 Cell Proliferation
Ye, Liang1,2,3; Jiang, Bo4; Deng, Jun5; Du, Jing6; Xiong, Wen7; Guan, Youfei8; Wen, Zhongyang1,2,3; Huang, Kunzhao1,2,3; Huang, Zhong1,2,3
刊名JOURNAL OF IMMUNOLOGY
2015-06-01
DOI10.4049/jimmunol.1401810
194期:11页:5110-5119
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]GROWTH-FACTOR-BETA ; COLLAGEN-INDUCED ARTHRITIS ; RHEUMATOLOGY/EUROPEAN LEAGUE ; AMERICAN-COLLEGE ; DENDRITIC CELLS ; SYNOVIAL-FLUID ; GAMMA-T ; INFLAMMATION ; INDUCTION ; DIFFERENTIATION
英文摘要

IL-37, a new member of the IL-1 cytokine family, is a natural inhibitor of innate immunity associated with autoimmune diseases. This study was undertaken to evaluate whether IL-37 has antiarthritic effects in patients with rheumatoid arthritis (RA) and in mice with collagen-induced arthritis (CIA). In this study, we analyzed the expression of IL-37 in PBMCs, serum, and lymphocytes from RA patients as well as CD4(+) T cells polarized under Th1/Th2/Th17 conditions. The role of IL-37 was assessed by investigating the effects of recombinant human (rh) IL-37 and an adenovirus encoding human IL-37 (Ad-IL-37) on Th17 cells and Th17-related cytokines in RA patients and CIA mice. We found that active RA patients showed higher IL-37 levels compared with patients with inactive RA and healthy controls. Upregulated IL-37 expression also was found in CD3(+) T cells and CD4(+) T cells from RA patients and in Th1/Th17-differentiation conditions. rhIL-37 markedly decreased IL-17 expression and Th17 cell frequency in PBMCs and CD4(+) T cells from RA patients. Furthermore, IL-37 exerted a more suppressive effect on Th17 cell proliferation, whereas it had little or no effect on Th17 cell differentiation. IL-17 and IL-17-driving cytokine production were significantly reduced in synovium and joint cells from CIA mice receiving injections of Ad-IL-37. Our findings indicate that IL-37 plays a potent immunosuppressive role in the pathogenesis of human RA and CIA models via the downregulation of IL-17 and IL-17-triggering cytokine production and the curbing of Th17 cell proliferation.

语种英语
WOS记录号WOS:000354905300013
项目编号81273305 ; JCYJ20140711144858545
资助机构National Natural Science Foundation of China ; Special Fund for Shenzhen Strategic Emerging Industry Development
引用统计
被引频次:53[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51336
专题北京大学深圳医院
作者单位1.Maoming City Peoples Hosp, Maoming 525000, Guangdong, Peoples R China
2.Shenzhen Blood Ctr, Shenzhen 518035, Guangdong, Peoples R China
3.Shenzhen Univ, Biol Therapy Inst, Shenzhen 518060, Guangdong, Peoples R China
4.Shenzhen Univ, Sch Med, Dept Pathogen Biol & Immunol, Shenzhen 518060, Guangdong, Peoples R China
5.Shenzhen City Shenzhen Univ, Immunodiagnost Technol Platform, Shenzhen 518060, Peoples R China
6.Univ Hong Kong, Dept Pathol, Hong Kong 999077, Hong Kong, Peoples R China
7.Peking Univ, Shenzhen Hosp, Dept Lab Med, Shenzhen 518036, Peoples R China
8.Shenzhen Univ, Ctr Diabet, Hlth Sci Ctr, Shenzhen 518060, Guangdong, Peoples R China
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GB/T 7714
Ye, Liang,Jiang, Bo,Deng, Jun,et al. IL-37 Alleviates Rheumatoid Arthritis by Suppressing IL-17 and IL-17-Triggering Cytokine Production and Limiting Th17 Cell Proliferation[J]. JOURNAL OF IMMUNOLOGY,2015,194(11):5110-5119.
APA Ye, Liang.,Jiang, Bo.,Deng, Jun.,Du, Jing.,Xiong, Wen.,...&Huang, Zhong.(2015).IL-37 Alleviates Rheumatoid Arthritis by Suppressing IL-17 and IL-17-Triggering Cytokine Production and Limiting Th17 Cell Proliferation.JOURNAL OF IMMUNOLOGY,194(11),5110-5119.
MLA Ye, Liang,et al."IL-37 Alleviates Rheumatoid Arthritis by Suppressing IL-17 and IL-17-Triggering Cytokine Production and Limiting Th17 Cell Proliferation".JOURNAL OF IMMUNOLOGY 194.11(2015):5110-5119.
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