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学科主题: 临床医学
题名:
In vitro activity of cefditoren and other comparators against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis causing community-acquired respiratory tract infections in China
作者: Yang, Qiwen1; Xu, Yingchun1; Chen, Minjun1; Wang, Hui2; Sun, Hongli1; Hu, Yunjian3; Zhang, Rong4; Duan, Qiong5; Zhuo, Chao6; Cao, Bin7; Liu, Yong8; Yu, Yunsong9; Sun, Ziyong10; Chu, Yunzhuo11
关键词: Cefditoren ; Streptococcus pneumoniae ; Haemophilus influenzae ; Moraxella catarrhalis ; Antimicrobial resistance
刊名: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
发表日期: 2012-06-01
DOI: 10.1016/j.diagmicrobio.2012.03.005
卷: 73, 期:2, 页:187-191
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases ; Microbiology
研究领域[WOS]: Infectious Diseases ; Microbiology
关键词[WOS]: ANTIMICROBIAL ACTIVITY ; PATHOGENS ; SUSCEPTIBILITY ; AMPICILLIN ; PENICILLIN ; AGENTS ; 2X
英文摘要:

The aim of this study was to evaluate the in vitro activity of cefditoren and comparators against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis causing community-acquired respiratory tract infections (CARTIs). A total of 391 Streptococcus pneumoniae, 266 H. influenzae, and 76 M. catarrhalis were isolated from 10 centers located at 6 cities in China from January 2009 to May 2010. The microdilution method was used to determine minimum inhibitory concentrations (MICs). The pneumococci comprised 189 (48.3%) penicillin susceptible, 129 (33.0%) penicillin intermediate, and 73 (18.7%) penicillin resistant. Moxifloxacin and levofloxacin showed the highest activity (99.2% and 97.7%, respectively) against Streptococcus pneumoniae, followed by parenteral penicillin G (95.7%), cefditoren (83.1%) and amoxicillin-clavulanic acid (79.3%). Among the 266 H. influenzae isolates, 26 (9.8%) were ampicillin-resistant beta-lactamase-producing strains and 24 (9.0%) were ampicillin-resistant beta-lactamase-nonproducing strains (BLNAR). Most of antimicrobial agents demonstrated good activity (>97% susceptibility) against H. influenzae except ampicillin, cefuroxime, and cefaclor, which showed relatively lower activity (81.2%, 88.7%, and 88%, respectively). Cefditoren showed excellent activity with the lowest MIC50 and MIC90 (<= 0.016/0.064 mu g/mL) among all tested drugs, which is independent of beta-lactamase production or ampicillin resistance. Cefditoren at a concentration of 0.5 mu g/mL inhibited all BLNAR strains. Seventy of 76 isolates of M. catarrhalis produced beta-lactamase. Cefditoren also showed excellent activity with MIC90 of 0.064 mu g/mL against beta-lactamase-nonproducing strains and 0.5 mu g/mL against beta-lactamase-producing strains. In conclusion, the excellent intrinsic activity of cefditoren suggests that it may be a good choice for the treatment of CARTIs caused by Streptococcus pneumoniae, H. influenzae, and M. catarrhalis in China, while the activity should be closely monitored. (C) 2012 Elsevier Inc. All rights reserved.

语种: 英语
项目资助者: Meiji Seika Pharma Co., Ltd.
WOS记录号: WOS:000305102100015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51341
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Beijing Chaoyang Hosp, Beijing 100020, Peoples R China
2.China Med Univ, Hosp 1, Shenyang 110001, Peoples R China
3.Beijing Univ, Peoples Hosp, Beijing 100044, Peoples R China
4.Beijing Hosp, Beijing 100730, Peoples R China
5.Peoples Hosp Jilin Prov, Changchun 130021, Peoples R China
6.Inst Resp Dis, Guangzhou 510120, Guangdong, Peoples R China
7.Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Clin Lab, Beijing 100730, Peoples R China
8.Zhejiang Univ, Affiliated Hosp 2, Hangzhou 310009, Zhejiang, Peoples R China
9.China Med Univ, Shengjing Hosp, Shenyang 110004, Peoples R China
10.Zhejiang Univ, Sch Med, Sir RunRun Shaw Hosp, Hangzhou 310016, Zhejiang, Peoples R China
11.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Peoples R China

Recommended Citation:
Yang, Qiwen,Xu, Yingchun,Chen, Minjun,et al. In vitro activity of cefditoren and other comparators against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis causing community-acquired respiratory tract infections in China[J]. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE,2012,73(2):187-191.
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