IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
In vitro activity of cefditoren and other comparators against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis causing community-acquired respiratory tract infections in China
Yang, Qiwen1; Xu, Yingchun1; Chen, Minjun1; Wang, Hui2; Sun, Hongli1; Hu, Yunjian3; Zhang, Rong4; Duan, Qiong5; Zhuo, Chao6; Cao, Bin7; Liu, Yong8; Yu, Yunsong9; Sun, Ziyong10; Chu, Yunzhuo11
关键词Cefditoren Streptococcus Pneumoniae Haemophilus Influenzae Moraxella Catarrhalis Antimicrobial Resistance
刊名DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
2012-06-01
DOI10.1016/j.diagmicrobio.2012.03.005
73期:2页:187-191
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases ; Microbiology
研究领域[WOS]Infectious Diseases ; Microbiology
关键词[WOS]ANTIMICROBIAL ACTIVITY ; PATHOGENS ; SUSCEPTIBILITY ; AMPICILLIN ; PENICILLIN ; AGENTS ; 2X
英文摘要

The aim of this study was to evaluate the in vitro activity of cefditoren and comparators against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis causing community-acquired respiratory tract infections (CARTIs). A total of 391 Streptococcus pneumoniae, 266 H. influenzae, and 76 M. catarrhalis were isolated from 10 centers located at 6 cities in China from January 2009 to May 2010. The microdilution method was used to determine minimum inhibitory concentrations (MICs). The pneumococci comprised 189 (48.3%) penicillin susceptible, 129 (33.0%) penicillin intermediate, and 73 (18.7%) penicillin resistant. Moxifloxacin and levofloxacin showed the highest activity (99.2% and 97.7%, respectively) against Streptococcus pneumoniae, followed by parenteral penicillin G (95.7%), cefditoren (83.1%) and amoxicillin-clavulanic acid (79.3%). Among the 266 H. influenzae isolates, 26 (9.8%) were ampicillin-resistant beta-lactamase-producing strains and 24 (9.0%) were ampicillin-resistant beta-lactamase-nonproducing strains (BLNAR). Most of antimicrobial agents demonstrated good activity (>97% susceptibility) against H. influenzae except ampicillin, cefuroxime, and cefaclor, which showed relatively lower activity (81.2%, 88.7%, and 88%, respectively). Cefditoren showed excellent activity with the lowest MIC50 and MIC90 (<= 0.016/0.064 mu g/mL) among all tested drugs, which is independent of beta-lactamase production or ampicillin resistance. Cefditoren at a concentration of 0.5 mu g/mL inhibited all BLNAR strains. Seventy of 76 isolates of M. catarrhalis produced beta-lactamase. Cefditoren also showed excellent activity with MIC90 of 0.064 mu g/mL against beta-lactamase-nonproducing strains and 0.5 mu g/mL against beta-lactamase-producing strains. In conclusion, the excellent intrinsic activity of cefditoren suggests that it may be a good choice for the treatment of CARTIs caused by Streptococcus pneumoniae, H. influenzae, and M. catarrhalis in China, while the activity should be closely monitored. (C) 2012 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000305102100015
资助机构Meiji Seika Pharma Co., Ltd.
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51341
专题北京大学第二临床医学院
作者单位1.Beijing Chaoyang Hosp, Beijing 100020, Peoples R China
2.China Med Univ, Hosp 1, Shenyang 110001, Peoples R China
3.Beijing Univ, Peoples Hosp, Beijing 100044, Peoples R China
4.Beijing Hosp, Beijing 100730, Peoples R China
5.Peoples Hosp Jilin Prov, Changchun 130021, Peoples R China
6.Inst Resp Dis, Guangzhou 510120, Guangdong, Peoples R China
7.Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Clin Lab, Beijing 100730, Peoples R China
8.Zhejiang Univ, Affiliated Hosp 2, Hangzhou 310009, Zhejiang, Peoples R China
9.China Med Univ, Shengjing Hosp, Shenyang 110004, Peoples R China
10.Zhejiang Univ, Sch Med, Sir RunRun Shaw Hosp, Hangzhou 310016, Zhejiang, Peoples R China
11.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Peoples R China
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GB/T 7714
Yang, Qiwen,Xu, Yingchun,Chen, Minjun,et al. In vitro activity of cefditoren and other comparators against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis causing community-acquired respiratory tract infections in China[J]. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE,2012,73(2):187-191.
APA Yang, Qiwen.,Xu, Yingchun.,Chen, Minjun.,Wang, Hui.,Sun, Hongli.,...&Chu, Yunzhuo.(2012).In vitro activity of cefditoren and other comparators against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis causing community-acquired respiratory tract infections in China.DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE,73(2),187-191.
MLA Yang, Qiwen,et al."In vitro activity of cefditoren and other comparators against Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis causing community-acquired respiratory tract infections in China".DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE 73.2(2012):187-191.
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