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Identification and Determination of the Major Constituents in the Traditional Uighur Medicinal Plant Saussurea involucrata by LC-DAD-MS
Yi, Tao1; Chen, Hu-Biao1; Zhao, Zhong-Zhen1; Jiang, Zhi-Hong1; Cai, Shao-Qing2; Wang, Tian-Min2
关键词Column Liquid Chromatography Diode Array Detection Electrospray Ionisation Mass Spectrometry Pharmaceutical Analysis Ethnopharmacy Saussurea Involucrata
刊名CHROMATOGRAPHIA
2009-03-01
DOI10.1365/s10337-008-0923-9
69期:5-6页:537-542
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]LIGUSTICUM-CHUANXIONG ; HPLC ; GUAIANOLIDES ; GLUCOSIDES ; ESI/MS
英文摘要

A liquid chromatography coupled with diode array detector and electrospray ionization mass spectrometry method was developed for the simultaneous analysis of the major constituents in Saussurea involucrata (SI). A comprehensive validation of the developed method was conducted, and the unique properties of the present method were confirmed by analyzing 11 SI samples. Seventeen compounds including phenolic acids, flavonoids, and lignanoids were identified by online ESI-MS and by comparison with known data in the literature and standard compounds; of these, eight were simultaneously quantified by LC-DAD. All linear regressions were acquired with R (2) > 0.99, and the limits of detection ranged from 0.85 to 3.03 ng. Repeatability was evaluated by intra- and inter-day assays; the relative standard deviation (RSD) value was within 4.95%. Recovery studies for the quantified compounds were found to be within the range 97.31-101.17% with an RSD of less than 2.18%. Overall, the present hyphenation procedure is highly efficient and reliable, and hence suitable for qualitative and quantitative analysis of a large number of samples.

语种英语
WOS记录号WOS:000263826600020
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51349
专题北京大学药学院
北京大学药学院_天然药物学系
作者单位1.Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Yi, Tao,Chen, Hu-Biao,Zhao, Zhong-Zhen,et al. Identification and Determination of the Major Constituents in the Traditional Uighur Medicinal Plant Saussurea involucrata by LC-DAD-MS[J]. CHROMATOGRAPHIA,2009,69(5-6):537-542.
APA Yi, Tao,Chen, Hu-Biao,Zhao, Zhong-Zhen,Jiang, Zhi-Hong,Cai, Shao-Qing,&Wang, Tian-Min.(2009).Identification and Determination of the Major Constituents in the Traditional Uighur Medicinal Plant Saussurea involucrata by LC-DAD-MS.CHROMATOGRAPHIA,69(5-6),537-542.
MLA Yi, Tao,et al."Identification and Determination of the Major Constituents in the Traditional Uighur Medicinal Plant Saussurea involucrata by LC-DAD-MS".CHROMATOGRAPHIA 69.5-6(2009):537-542.
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