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Angiogenesis inhibition and cell cycle arrest induced by treatment with Pseudolarix acid B alone or combined with 5-fluorouracil
Liu, Jingtao; Guo, Wei; Xu, Bo; Ran, Fuxiang; Chu, Mingming; Fu, Hongzheng; Cui, Jingrong
关键词Combination Therapy Angiogenesis Inhibition Cell Cycle Arrest Pseudolarix Acid b 5-fluorouracil
刊名ACTA BIOCHIMICA ET BIOPHYSICA SINICA
2012-06-01
DOI10.1093/abbs/gms029
44期:6页:490-502
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]ENDOTHELIAL GROWTH-FACTOR ; TUMOR ANGIOGENESIS ; APOPTOSIS ; CANCER ; OVEREXPRESSION ; CHEMOTHERAPY ; HYPOXIA ; AGENT ; MODEL ; VEGF
英文摘要

Angiogenesis inhibitors combined with chemotherapeutic drugs have significant efficacy in the treatment of a variety of cancers. Pseudolarix acid B (PAB) is a traditional pregnancy-terminating agent, which has previously been shown to reduce tumor growth and angiogenesis. In this study, we used the high content screening assay to examine the effects of PAB on human umbilical vein endothelial cells (HUVECs). Two hepatocarcinoma 22-transplanted mouse models were used to determine PAB efficacy in combination with 5-fluorouracil (5-Fu). Our results suggested that PAB (0.1561.250 M) inhibited HUVECs motility in a concentration-dependent manner without obvious cytotoxicity in vitro. In vivo, PAB (25 mg/kg/day) promoted the anti-tumor efficacy of 5-Fu (5 mg/kg/2 days) in combination therapy, resulting in significantly higher tumor inhibition rates, lower microvessel density values, and prolonged survival times. It was also demonstrated that PAB acted by blocking the cell cycle at both the G(1)/S boundary and M phase, down-regulation of vascular endothelial growth factor, hypoxia-inducible factor 1 and cyclin E expression, and up-regulation of cdc2 expression. These observations provide the first evidence that PAB in combination with 5-Fu may be useful in cancer treatment.

语种英语
WOS记录号WOS:000304830700004
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51350
专题北京大学临床肿瘤学院_肿瘤放疗科
北京大学药学院
北京大学药学院_天然药物与仿生药物国家重点实验室
北京大学药学院_分子与细胞药理学系
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Liu, Jingtao,Guo, Wei,Xu, Bo,et al. Angiogenesis inhibition and cell cycle arrest induced by treatment with Pseudolarix acid B alone or combined with 5-fluorouracil[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2012,44(6):490-502.
APA Liu, Jingtao.,Guo, Wei.,Xu, Bo.,Ran, Fuxiang.,Chu, Mingming.,...&Cui, Jingrong.(2012).Angiogenesis inhibition and cell cycle arrest induced by treatment with Pseudolarix acid B alone or combined with 5-fluorouracil.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,44(6),490-502.
MLA Liu, Jingtao,et al."Angiogenesis inhibition and cell cycle arrest induced by treatment with Pseudolarix acid B alone or combined with 5-fluorouracil".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 44.6(2012):490-502.
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