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学科主题: 药学
题名:
Microfluidic sterilization
作者: Zhang, Rui1,2; Huang, Jie1; Xie, Fei1; Wang, Baojun1; Chu, Ming3; Wang, Yuedan3; Li, Haichao4; Wang, Wei1,5,6; Zhang, Haixia1,5,6; Wu, Wengang1,5,6; Li, Zhihong1,5,6
刊名: BIOMICROFLUIDICS
发表日期: 2014-05-01
DOI: 10.1063/1.4882776
卷: 8, 期:3
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Biophysics ; Nanoscience & Nanotechnology ; Physics, Fluids & Plasmas
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Science & Technology - Other Topics ; Physics
关键词[WOS]: TOTAL ANALYSIS SYSTEMS ; HIGH-PRESSURE ; CELL-CULTURE ; MICROREACTOR
英文摘要:

Nowadays, microfluidics is attracting more and more attentions in the biological society and has provided powerful solutions for various applications. This paper reported a microfluidic strategy for aqueous sample sterilization. A well-designed small microchannel with a high hydrodynamic resistance was used to function as an in-chip pressure regulator. The pressure in the upstream microchannel was thereby elevated which made it possible to maintain a boiling-free high temperature environment for aqueous sample sterilization. A 120 degrees C temperature along with a pressure of 400 kPa was successfully achieved inside the chip to sterilize aqueous samples with E. coli and Staphylococcus aureus inside. This technique will find wide applications in portable cell culturing, microsurgery in wild fields, and other related micro total analysis systems. (C) 2014 AIP Publishing LLC.

语种: 英语
所属项目编号: 2011CB309502 ; 91023045 ; 91323304
项目资助者: Major State Basic Research Development Program (973 Program) ; National Natural Science Foundation of China ; 985-III program (clinical applications) in Peking University
WOS记录号: WOS:000339004500019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51353
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Inst Microelect, Beijing 100871, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Beijing 100191, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
4.Peking Univ, Peking Univ First Hosp, Beijing 100034, Peoples R China
5.Natl Key Lab Sci & Technol Micro Nano Fabricat, Beijing 100871, Peoples R China
6.Innovat Ctr MicroNanoelect & Integrated Syst, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Rui,Huang, Jie,Xie, Fei,et al. Microfluidic sterilization[J]. BIOMICROFLUIDICS,2014,8(3).
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