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Improving Cytomegalovirus-Specific T Cell Reconstitution after Haploidentical Stem Cell Transplantation
Luo, Xiao-Hua1; Chang, Ying-Jun2,3; Huang, Xiao-Jun2,3
刊名JOURNAL OF IMMUNOLOGY RESEARCH
2014
DOI10.1155/2014/631951
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]COLONY-STIMULATING FACTOR ; BONE-MARROW-TRANSPLANTATION ; IDENTICAL SIBLING TRANSPLANTATION ; INTENSITY CONDITIONING REGIMEN ; RISK HEMATOLOGIC MALIGNANCIES ; TERM IMMUNE RECONSTITUTION ; ACUTE-LEUKEMIA ; ANTITHYMOCYTE GLOBULIN ; ADOPTIVE IMMUNOTHERAPY ; SEROPOSITIVE RECIPIENTS
英文摘要

Cytomegalovirus (CMV) infection and delayed immune reconstitution (IR) remain serious obstacles for successful haploidentical stem cell transplantation (haplo-SCT). CMV-specific IR varied according to whether patients received manipulated/unmanipulated grafts or myeloablative/reduced intensity conditioning. CMV infection commonly occurs following impaired IR of T cell and its subsets. Here, we discuss the factors that influence IR based on currently available evidence. Adoptive transfer of donor T cells to improve CMV-specific IR is discussed. One should choose grafts from CMV-positive donors for transplant into CMV-positive recipients (D+/R+) because this will result in better IR than would grafts from CMV-negative donors (D-/R+). Stem cell source and donor age are other important factors. Posttransplant complications, including graft-versus-host disease and CMV infection, as well as their associated treatments, should also be considered. The effects of varying degrees of HLA disparity and conditioning regimens are more controversial. As many of these factors and strategies are considered in the setting of haplo-SCT, it is anticipated that haplo-SCT will continue to advance, further expanding our understanding of IR and CMV infection.

语种英语
WOS记录号WOS:000335307300001
项目编号81230013 ; 81100388
资助机构National Natural Science Foundation of China ; Chang Jiang Scholars Program
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51354
专题北京大学第二临床医学院
北京大学第二临床医学院_血液科
作者单位1.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
2.Chongqing Med Univ, Affiliated Hosp 1, Dept Hematol, Chongqing 400016, Peoples R China
3.Peking Univ, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Luo, Xiao-Hua,Chang, Ying-Jun,Huang, Xiao-Jun. Improving Cytomegalovirus-Specific T Cell Reconstitution after Haploidentical Stem Cell Transplantation[J]. JOURNAL OF IMMUNOLOGY RESEARCH,2014.
APA Luo, Xiao-Hua,Chang, Ying-Jun,&Huang, Xiao-Jun.(2014).Improving Cytomegalovirus-Specific T Cell Reconstitution after Haploidentical Stem Cell Transplantation.JOURNAL OF IMMUNOLOGY RESEARCH.
MLA Luo, Xiao-Hua,et al."Improving Cytomegalovirus-Specific T Cell Reconstitution after Haploidentical Stem Cell Transplantation".JOURNAL OF IMMUNOLOGY RESEARCH (2014).
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