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学科主题: 临床医学
题名:
Improving Cytomegalovirus-Specific T Cell Reconstitution after Haploidentical Stem Cell Transplantation
作者: Luo, Xiao-Hua1; Chang, Ying-Jun2,3; Huang, Xiao-Jun2,3
刊名: JOURNAL OF IMMUNOLOGY RESEARCH
发表日期: 2014
DOI: 10.1155/2014/631951
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: COLONY-STIMULATING FACTOR ; BONE-MARROW-TRANSPLANTATION ; IDENTICAL SIBLING TRANSPLANTATION ; INTENSITY CONDITIONING REGIMEN ; RISK HEMATOLOGIC MALIGNANCIES ; TERM IMMUNE RECONSTITUTION ; ACUTE-LEUKEMIA ; ANTITHYMOCYTE GLOBULIN ; ADOPTIVE IMMUNOTHERAPY ; SEROPOSITIVE RECIPIENTS
英文摘要:

Cytomegalovirus (CMV) infection and delayed immune reconstitution (IR) remain serious obstacles for successful haploidentical stem cell transplantation (haplo-SCT). CMV-specific IR varied according to whether patients received manipulated/unmanipulated grafts or myeloablative/reduced intensity conditioning. CMV infection commonly occurs following impaired IR of T cell and its subsets. Here, we discuss the factors that influence IR based on currently available evidence. Adoptive transfer of donor T cells to improve CMV-specific IR is discussed. One should choose grafts from CMV-positive donors for transplant into CMV-positive recipients (D+/R+) because this will result in better IR than would grafts from CMV-negative donors (D-/R+). Stem cell source and donor age are other important factors. Posttransplant complications, including graft-versus-host disease and CMV infection, as well as their associated treatments, should also be considered. The effects of varying degrees of HLA disparity and conditioning regimens are more controversial. As many of these factors and strategies are considered in the setting of haplo-SCT, it is anticipated that haplo-SCT will continue to advance, further expanding our understanding of IR and CMV infection.

语种: 英语
所属项目编号: 81230013 ; 81100388
项目资助者: National Natural Science Foundation of China ; Chang Jiang Scholars Program
WOS记录号: WOS:000335307300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51354
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
2.Chongqing Med Univ, Affiliated Hosp 1, Dept Hematol, Chongqing 400016, Peoples R China
3.Peking Univ, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China

Recommended Citation:
Luo, Xiao-Hua,Chang, Ying-Jun,Huang, Xiao-Jun. Improving Cytomegalovirus-Specific T Cell Reconstitution after Haploidentical Stem Cell Transplantation[J]. JOURNAL OF IMMUNOLOGY RESEARCH,2014.
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