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学科主题: 临床医学
题名:
Using different methods to evaluate the efficacy of olmesartan medoxomil in Chinese patients with mild to moderate essential hypertension according to ambulatory blood pressure monitoring
作者: Jiang, Hong1; Ke, Yuan-nan1; Sun, Ning-ling2; Wang, Ji-guang3; Hou, Ming-wei4; Zhu, Jun-ren5; Olmesartan Medoxomil Clinical Coll1
关键词: ambulatory blood pressure monitoring ; hypertension ; olmesartan medoxomil ; smoothness index ; trough-to-peak ratio
刊名: BLOOD PRESSURE MONITORING
发表日期: 2012-10-01
DOI: 10.1097/MBP.0b013e3283588513
卷: 17, 期:5, 页:193-197
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
英文摘要:

Objective To evaluate the efficacy of olmesartan medoxomil in Chinese patients with mild to moderate essential hypertension using different methods according to ambulatory blood pressure monitoring.

Methods Chinese patients 18-75 years of age with clinic diastolic blood pressure (BP) 90-109 mmHg and systolic BP less than 180 mmHg were treated with olmesartan medoxomil 20-40 mg once daily for 24 weeks to reach the goal BP (<140/90 and <130/80 mmHg in diabetes) in a multicenter study. The trough-to-peak ratio (T/P ratio) and the smoothness index (SI) for systolic/diastolic BP were calculated using different methods according to ambulatory blood pressure monitoring.

Result Olmesartan medoxomil 20-40 mg once daily reduced the systolic/diastolic ambulatory BP for 24-h, daytime, and night-time by 13.3 +/- 16.3/7.6 +/- 9.5, 13.9 +/- 17.4/8.0 +/- 10.4, and 12.3 +/- 18.1/6.8 +/- 10.2 mmHg in all eligible patients at week 24 from baseline (n=87, P<0.0001). The global and individual T/P ratios were 0.64/0.62 and 0.32/0.30 (n=87) for systolic/diastolic BP, whereas these were 0.71/0.70 and 0.31/0.39 in fair responders (n=71). Global and individual SI were 6.81/5.37 and 0.92/0.67 (n=87) for systolic/diastolic BP, whereas these were 7.04/5.44 and 1.03/1.03 in fair responders (n=71). Global and individual T/P ratios for systolic/diastolic BP were 0.75/0.82 and 0.45/0.46 in the 20 mg subgroup (n = 41), whereas these were 0.44/0.59 and 0.30/0.29 in the 40 mg subgroup (n=30). Global and individual SI were 5.70/5.32 and 1.03/0.87 for systolic/diastolic BP in the 20 mg subgroup (n = 41), but these were 3.64/2.46 and 1.01/0.60 in the 40 mg subgroup (n=30).

Conclusion The duration of the antihypertensive action of olmesartan medoxomil with 20-40 mg once daily can be assessed by the global T/P ratio and SI rather than the individual values, even in different populations and dosages. Blood Press Monit 17: 193-197 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

语种: 英语
项目资助者: Daiichi Sankyo Pharmaceutical Co. Ltd (Shanghai, China)
WOS记录号: WOS:000308922200003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51367
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.China Japan Friendship Hosp, Dept Cardiol, Beijing 100029, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100871, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Shanghai Inst Hypertens,Ctr Epidemiol Studies & C, Shanghai 200030, Peoples R China
4.Daiichi Sankyo Pharmaceut Co Ltd, Dept Med Affairs, Shanghai, Peoples R China
5.Fudan Univ, Zhongshan Hosp, Dept Cardiol, Shanghai 200433, Peoples R China

Recommended Citation:
Jiang, Hong,Ke, Yuan-nan,Sun, Ning-ling,et al. Using different methods to evaluate the efficacy of olmesartan medoxomil in Chinese patients with mild to moderate essential hypertension according to ambulatory blood pressure monitoring[J]. BLOOD PRESSURE MONITORING,2012,17(5):193-197.
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