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Using different methods to evaluate the efficacy of olmesartan medoxomil in Chinese patients with mild to moderate essential hypertension according to ambulatory blood pressure monitoring
Jiang, Hong1; Ke, Yuan-nan1; Sun, Ning-ling2; Wang, Ji-guang3; Hou, Ming-wei4; Zhu, Jun-ren5; Olmesartan Medoxomil Clinical Coll1
关键词Ambulatory Blood Pressure Monitoring Hypertension Olmesartan Medoxomil Smoothness Index Trough-to-peak Ratio
刊名BLOOD PRESSURE MONITORING
2012-10-01
DOI10.1097/MBP.0b013e3283588513
17期:5页:193-197
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
资助者Daiichi Sankyo Pharmaceutical Co. Ltd (Shanghai, China) ; Daiichi Sankyo Pharmaceutical Co. Ltd (Shanghai, China)
研究领域[WOS]Cardiovascular System & Cardiology
英文摘要

Objective To evaluate the efficacy of olmesartan medoxomil in Chinese patients with mild to moderate essential hypertension using different methods according to ambulatory blood pressure monitoring.

Methods Chinese patients 18-75 years of age with clinic diastolic blood pressure (BP) 90-109 mmHg and systolic BP less than 180 mmHg were treated with olmesartan medoxomil 20-40 mg once daily for 24 weeks to reach the goal BP (<140/90 and <130/80 mmHg in diabetes) in a multicenter study. The trough-to-peak ratio (T/P ratio) and the smoothness index (SI) for systolic/diastolic BP were calculated using different methods according to ambulatory blood pressure monitoring.

Result Olmesartan medoxomil 20-40 mg once daily reduced the systolic/diastolic ambulatory BP for 24-h, daytime, and night-time by 13.3 +/- 16.3/7.6 +/- 9.5, 13.9 +/- 17.4/8.0 +/- 10.4, and 12.3 +/- 18.1/6.8 +/- 10.2 mmHg in all eligible patients at week 24 from baseline (n=87, P<0.0001). The global and individual T/P ratios were 0.64/0.62 and 0.32/0.30 (n=87) for systolic/diastolic BP, whereas these were 0.71/0.70 and 0.31/0.39 in fair responders (n=71). Global and individual SI were 6.81/5.37 and 0.92/0.67 (n=87) for systolic/diastolic BP, whereas these were 7.04/5.44 and 1.03/1.03 in fair responders (n=71). Global and individual T/P ratios for systolic/diastolic BP were 0.75/0.82 and 0.45/0.46 in the 20 mg subgroup (n = 41), whereas these were 0.44/0.59 and 0.30/0.29 in the 40 mg subgroup (n=30). Global and individual SI were 5.70/5.32 and 1.03/0.87 for systolic/diastolic BP in the 20 mg subgroup (n = 41), but these were 3.64/2.46 and 1.01/0.60 in the 40 mg subgroup (n=30).

Conclusion The duration of the antihypertensive action of olmesartan medoxomil with 20-40 mg once daily can be assessed by the global T/P ratio and SI rather than the individual values, even in different populations and dosages. Blood Press Monit 17: 193-197 (C) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

语种英语
资助者Daiichi Sankyo Pharmaceutical Co. Ltd (Shanghai, China) ; Daiichi Sankyo Pharmaceutical Co. Ltd (Shanghai, China)
WOS记录号WOS:000308922200003
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51367
专题北京大学第二临床医学院_心血管内科
作者单位1.China Japan Friendship Hosp, Dept Cardiol, Beijing 100029, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100871, Peoples R China
3.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Shanghai Inst Hypertens,Ctr Epidemiol Studies & C, Shanghai 200030, Peoples R China
4.Daiichi Sankyo Pharmaceut Co Ltd, Dept Med Affairs, Shanghai, Peoples R China
5.Fudan Univ, Zhongshan Hosp, Dept Cardiol, Shanghai 200433, Peoples R China
推荐引用方式
GB/T 7714
Jiang, Hong,Ke, Yuan-nan,Sun, Ning-ling,et al. Using different methods to evaluate the efficacy of olmesartan medoxomil in Chinese patients with mild to moderate essential hypertension according to ambulatory blood pressure monitoring[J]. BLOOD PRESSURE MONITORING,2012,17(5):193-197.
APA Jiang, Hong.,Ke, Yuan-nan.,Sun, Ning-ling.,Wang, Ji-guang.,Hou, Ming-wei.,...&Olmesartan Medoxomil Clinical Coll.(2012).Using different methods to evaluate the efficacy of olmesartan medoxomil in Chinese patients with mild to moderate essential hypertension according to ambulatory blood pressure monitoring.BLOOD PRESSURE MONITORING,17(5),193-197.
MLA Jiang, Hong,et al."Using different methods to evaluate the efficacy of olmesartan medoxomil in Chinese patients with mild to moderate essential hypertension according to ambulatory blood pressure monitoring".BLOOD PRESSURE MONITORING 17.5(2012):193-197.
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