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学科主题: 临床医学
题名:
Efficacy of folic acid supplementation in stroke prevention: a meta-analysis
作者: Wang, Xiaobin1; Qin, Xianhui1; Demirtas, Hakan1; Li, Jianping1; Mao, Guangyun1; Huo, Yong1; Sun, Ningling1; Liu, Lisheng1; Xu, Xiping1
刊名: LANCET
发表日期: 2007-06-02
卷: 369, 期:9576, 页:1876-1882
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: RANDOMIZED CONTROLLED-TRIALS ; ACUTE MYOCARDIAL-INFARCTION ; CORONARY-ARTERY DISEASE ; ISCHEMIC-HEART-DISEASE ; CARDIOVASCULAR EVENTS ; PLASMA HOMOCYSTEINE ; VASCULAR-DISEASE ; CEREBROVASCULAR-DISEASE ; SECONDARY PREVENTION ; UNITED-STATES
英文摘要:

Background The efficacy of treatments that lower homocysteine concentrations in reducing the risk of cardiovascular disease remains controversial. Our aim was to do a meta-analysis of relevant randomised trials to assess the efficacy of folic acid supplementation in the prevention of stroke. Methods We collected data from eight randomised trials of folic acid that had stroke reported as one of the endpoints. Relative risk (RR) was used as a measure of the effect of folic acid supplementation on the risk of stroke with a random effect model. The analysis was further stratified by factors that could affect the treatment effects. Findings Folic acid supplementation significantly reduced the risk of stroke by 18% (RR 0.82, 95% CI 0.68-1.00; p=0.045). In the stratified analyses, a greater beneficial effect was seen in those trials with a treatment duration of more than 36 months (0.71, 0.57-0.87; p=0.001), a decrease in the concentration of homocysteine of more than 20% (0.77, 0.63-0.94; p=0.012), no fortification or partly fortified grain (0.75, 0.62-0.91; p=0.003), and no history of stroke (0.75, 0.62-0.90; p=0.002). In the corresponding comparison groups, the estimated RRs were attenuated and insignificant. Interpretation Our findings indicate that folic acid supplementation can effectively reduce the risk of stroke in primary prevention.

语种: 英语
WOS记录号: WOS:000246911600031
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51370
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Anhui Med Univ, Inst Biomed, Hefei, Peoples R China
2.Childrens Mem Hosp, Mary Ann & J Milburn Smith Child Hlth Res Program, Chicago, IL 60614 USA
3.Northwestern Univ, Feinberg Sch Med, Childrens Mem Res Ctr, Chicago, IL 60611 USA
4.Univ Illinois, Chicago Sch Publ Hlth, Div Epidemiol & Biostat, Chicago, IL USA
5.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China
6.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100871, Peoples R China
7.Fu Wai Hosp, Div Hypertens, Beijing, Peoples R China
8.Chinese Acad Med Sci, Cardiovasc Inst, Beijing 100037, Peoples R China

Recommended Citation:
Wang, Xiaobin,Qin, Xianhui,Demirtas, Hakan,et al. Efficacy of folic acid supplementation in stroke prevention: a meta-analysis[J]. LANCET,2007,369(9576):1876-1882.
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