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学科主题: 临床医学
题名:
Mutations in components of the Wnt signaling pathway in gastric cancer
作者: Pan, Kai-Feng2,3; Liu, Wan-Guo4; Zhang, Lian2,3; You, Wei-Cheng2,3; Lu, You-Yong1,3
关键词: AXIN1 ; AXIN2 ; beta-catenin ; Wnt signaling pathway ; gastric cancer
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2008-03-14
DOI: 10.3748/wjg.14.1570
卷: 14, 期:10, 页:1570-1574
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ; BETA-CATENIN ; MICROSATELLITE INSTABILITY ; HEPATOCELLULAR CARCINOMAS ; ADENOMATOUS-POLYPOSIS ; GERMLINE MUTATIONS ; COLORECTAL-CANCER ; AXIN1 ; GENE ; APC
英文摘要:

AIM: To explore the contribution of AXIN1, AXIN2 and beta-catenin, components of Writ signaling pathway, to the carcinogenesis of gastric cancer (GC), we examined AXIN1, AXIN2 exon7 and CTNNB1 (encoding beta-catenin) exon3 mutations in 70 GCs.

METHODS: The presence of mutations was identified by polymerase chain reaction (PCR)-based denaturing high-performance liquid chromatography and direct DNA sequencing. Beta-catenin expression was detected by immunohistochemical analysis.

RESULTS: Among the 70 GCs, 5 (7.1%) had mutations in one or two of these three components. A frameshift mutation (1 bp deletion) in exon7 of AXIN2 was found in one case. Four cases, including the case with a mutation in AXIN2, had frameshift mutations and missense mutations in AXIN1. Five single nucleotide polymorphisms (SNPs), 334 C>T, 874 C>T, 1396 G>A, 1690 C>T and 1942 T>G, were identified in AXIN1. A frameshift mutation (27 bp deletion) spanning exon3 of CTNNB1 was observed in one case. All four cases with mutations in AXIN1 and AXIN2 showed nuclear beta-catenin expression.

CONCLUSION: These data indicate that the mutations in AXIN1 and AXIN2 may contribute to gastric carcinogenesis. (C) 2008 WJG. All rights reserved.

语种: 英语
WOS记录号: WOS:000254054700017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51372
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Beijing Canc Hosp & Inst, Beijing 100036, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Lab Mol Oncol, Beijing 100036, Peoples R China
3.Peking Univ, Sch Oncol, Dept Canc Epidemiol, Beijing 100036, Peoples R China
4.Mayo Clin & Mayo Grad Sch Med, Mayo Clin, Dept Lab Med & Pathol, Div Expt Pathol, Rochester, MN 55905 USA

Recommended Citation:
Pan, Kai-Feng,Liu, Wan-Guo,Zhang, Lian,et al. Mutations in components of the Wnt signaling pathway in gastric cancer[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2008,14(10):1570-1574.
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