IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Gastrointestinal Stromal Tumors Treated with Imatinib Mesylate: Apparent Diffusion Coefficient in the Evaluation of Therapy Response in Patients
Tang, Lei1; Zhang, Xiao-Peng1; Sun, Ying-Shi1; Shen, Lin2; Li, Jian2; Qi, Li-Ping1; Cui, Yong1
刊名RADIOLOGY
2011-03-01
DOI10.1148/radiol.10100402
258期:3页:729-738
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]TARGETED THERAPY ; HEPATOCELLULAR-CARCINOMA ; EMISSION-TOMOGRAPHY ; RADIATION-THERAPY ; BREAST-CANCER ; RECTAL-CANCER ; SOLID TUMORS ; FDG-PET ; MRI ; GIST
英文摘要

Purpose: To prospectively investigate the use of the apparent diffusion coefficient (ADC) as an early response indicator in patients with gastrointestinal stromal tumors (GISTs) treated with imatinib mesylate.

Materials and Methods: This study was approved by the institutional review board and written informed consent was obtained from all patients. Diffusion-weighted magnetic resonance (MR) imaging was performed in 32 patients with GISTs before and 1, 4, and 12 weeks after treatment with a tyrosine kinase inhibitor, imatinib mesylate. The measurable lesions were classified as having responded well or poorly according to size alterations at clinical evaluation following the first round of treatment (3 months). A linear mixed-effects model was applied to analyze changes in the ADCs of tumors during treatment and to compare the variation and slopes of the time-dependent ADC curves between the good-and poor-response groups.

Results: There were 56 lesions in the good-response group and 35 in the poor-response group. An early (1 week after therapy) noticeable and statistically significant (P < .001) increase in the ADC was observed in the good-response group (median ADC increase, 44.8%) but not in the poor-response group (median ADC increase, 1.5%). The time-dependent ADC variation was significantly different between the good- and poor-response groups, with a sharper median ADC increase displayed in the former (week 1: 44.8% vs 1.5%; week 4: 80.4% vs 7.8%; week 12: 89.6% vs 16.7%; F = 25.78, P < .001). The largest difference in the weekly percentage increase in ADC between the good-and poor-response groups was observed at 1 week after therapy (week 0-1: 44.8% vs 1.5%; week 1-4: 7.0% vs 2.8%; week 4-12: 1.6% vs 0.7%). The pretherapy mean ADC (+/- standard deviation) of lesions in the good-response group (1.06 [x 10(-3) mm(2)/sec] +/- 0.27) was signifi cantly lower than that in the poor-response group (1.24 [x 10(-3) mm(2)/sec] +/- 0.32) (F = 8.34, P = .005).

Conclusion: Comparatively low pretherapy ADC and marked ADC increase at 1 week after therapy is associated with good response to imatinib mesylate in patients with GISTs. (C)RSNA, 2010

语种英语
WOS记录号WOS:000287573100009
项目编号2011CB707705 ; 30970825 ; 7092020
资助机构National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Natural Science Foundation of Beijing, China
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/51374
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_消化肿瘤内科
北京大学临床肿瘤学院_医学影像科
作者单位1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Dept Radiol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Gastroenterol, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Tang, Lei,Zhang, Xiao-Peng,Sun, Ying-Shi,et al. Gastrointestinal Stromal Tumors Treated with Imatinib Mesylate: Apparent Diffusion Coefficient in the Evaluation of Therapy Response in Patients[J]. RADIOLOGY,2011,258(3):729-738.
APA Tang, Lei.,Zhang, Xiao-Peng.,Sun, Ying-Shi.,Shen, Lin.,Li, Jian.,...&Cui, Yong.(2011).Gastrointestinal Stromal Tumors Treated with Imatinib Mesylate: Apparent Diffusion Coefficient in the Evaluation of Therapy Response in Patients.RADIOLOGY,258(3),729-738.
MLA Tang, Lei,et al."Gastrointestinal Stromal Tumors Treated with Imatinib Mesylate: Apparent Diffusion Coefficient in the Evaluation of Therapy Response in Patients".RADIOLOGY 258.3(2011):729-738.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Tang, Lei]的文章
[Zhang, Xiao-Peng]的文章
[Sun, Ying-Shi]的文章
百度学术
百度学术中相似的文章
[Tang, Lei]的文章
[Zhang, Xiao-Peng]的文章
[Sun, Ying-Shi]的文章
必应学术
必应学术中相似的文章
[Tang, Lei]的文章
[Zhang, Xiao-Peng]的文章
[Sun, Ying-Shi]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。