北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学口腔医学院  > 口腔病理科  > 期刊论文
学科主题: 口腔医学
题名:
Central Mucoepidermoid Carcinoma: A Clinicopathologic and Immunohistochemical Study of 39 Chinese Patients
作者: Zhou, Chuan-Xiang1,4; Chen, Xin-Ming2,3; Li, Tie-Jun1,4
关键词: central mucoepidermoid carcinoma ; clinicopathologic profile ; pathogenesis ; immunohistochemistry
刊名: AMERICAN JOURNAL OF SURGICAL PATHOLOGY
发表日期: 2012
卷: 36, 期:1, 页:18-26
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology ; Surgery
研究领域[WOS]: Pathology ; Surgery
关键词[WOS]: TUMORS ; JAWS
英文摘要:

Central mucoepidermoid carcinoma (MEC) is a rare neoplasm arising intraosseously in the jaws. To clarify the clinicopathologic profile and pathogenesis of central MEC, clinicopathologic findings and follow-up data of 39 cases were collected and analyzed. There were 16 male and 23 female patients (median age, 43 y). Sixteen cases affected the maxilla, and 23 occurred in the mandible. Radiographically, most cases (32 of 39) showed a unilocular or multilocular radiolucency with bone destruction, and 7 were found with scattered calcification. The margins of the lesions were ill defined or diffused in 14 cases and relatively well defined in 25 cases. Most cases (26 of 39) were classified as low-grade MECs, whereas 13 were moderate-to-high grade. Follow-up data were available for 35 patients with a median period of 36 months. All cases were found to be primary; local recurrence occurred in 8 cases, most (75.0%) of which were low-grade tumors. Four cases showed regional lymph node metastasis, and I developed distant metastasis. Of 11 cases with a clinical history of the jaw cyst, 8 initially showed a typical odontogenic cyst with local MEC-like proliferation. In summary, the most likely pathogenesis of central MEC is neoplastic transformation of the epithelial lining of an odontogenic cyst, diagnosis of which should be based on clinical, radiographic, and histopathologic findings. The immunohistochemical profile of keratins is helpful in differential diagnosis. Radical surgery is the treatment of choice, whereas the role of radiotherapy or chemotherapy is still controversial, and careful long-term follow-up is necessary.

语种: 英语
WOS记录号: WOS:000298713300004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/51375
Appears in Collections:北京大学口腔医学院_口腔病理科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
2.Wuhan Univ, Sch Stomatol, Dept Oral Pathol, Wuhan 430072, Peoples R China
3.Wuhan Univ, Hosp Stomatol, Dept Oral Pathol, Wuhan 430072, Peoples R China
4.Peking Univ, Hosp Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China

Recommended Citation:
Zhou, Chuan-Xiang,Chen, Xin-Ming,Li, Tie-Jun. Central Mucoepidermoid Carcinoma: A Clinicopathologic and Immunohistochemical Study of 39 Chinese Patients[J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY,2012,36(1):18-26.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhou, Chuan-Xiang]'s Articles
[Chen, Xin-Ming]'s Articles
[Li, Tie-Jun]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhou, Chuan-Xiang]‘s Articles
[Chen, Xin-Ming]‘s Articles
[Li, Tie-Jun]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace